Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Owais M. Bhat"'
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
Humans are constantly facing multiple health challenges from both communicable and non-communicable diseases that significantly affect their health. Additionally, drug resistance or failure has made the situation even worse and poses serious challeng
Externí odkaz:
https://doaj.org/article/a2c309469191445091aadae6f8771a5e
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100298- (2022)
The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome is activated during atherogenesis, but how this occurs is unclear. Here, we explored the mechanisms activating and regulating NLRP3 inflammasomes via the acid sphingomyelinase (ASM)-ceramide s
Externí odkaz:
https://doaj.org/article/96c9c5b6f88f44d9b1520687c7ec07ea
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Recent studies have indicated that instant cell membrane resealing (ICMR) controls the activation of NOD-like receptor pyrin domain containing 3 (Nlrp3) inflammasomes in endothelial cells, thereby initiating and promoting vascular inflammation. It re
Externí odkaz:
https://doaj.org/article/8e292cf5d94a47d685bdcaddb0cb46fb
Autor:
Owais M. Bhat, Pin-Lan Li
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 3, Pp 277-300 (2021)
Externí odkaz:
https://doaj.org/article/34f32a92f7a7443fbf336ca0455eb062
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Recent studies reported that vascular endothelial cells (ECs) secrete NLR family pyrin domain-containing 3 (NLRP3) inflammasome products such as interleukin-1β (IL-1β) via extracellular vesicles (EVs) under various pathological conditions. EVs repr
Externí odkaz:
https://doaj.org/article/8bd28e9517b946fc97777ea23350536a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
High-mobility group box 1 protein (HMGB1) has been reported to trigger lysosome destabilization causing a wide of inflammatory diseases. The present study tested whether a lysosomal enzyme, acid ceramidase (AC), plays a critical role in HMGB1-induced
Externí odkaz:
https://doaj.org/article/bdfbf6a345174c409c5322fb96adc4de
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted by intestinal enteroendocrine L-cells, which plays a crucial role in glucose control, regulation, and protection from different pathological conditions such as diabetes mellitu
Externí odkaz:
https://doaj.org/article/ff333307213144fab29ea3fe363aee36
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 21-31 (2018)
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action
Externí odkaz:
https://doaj.org/article/12780a6033364363ae1a9be0a190f693
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 336-344 (2017)
The NLRP3 inflammasome has been reported to be activated by atherogenic factors, whereby endothelial injury and consequent atherosclerotic lesions are triggered in the arterial wall. However, the mechanisms activating and regulating NLRP3 inflammasom
Externí odkaz:
https://doaj.org/article/e9a54d7f470047cf8645492e192cfc0c
Autor:
Guangbi Li, Zhida Chen, Owais M. Bhat, Qinghua Zhang, Justine M. Abais-Battad, Sabena M. Conley, Joseph K. Ritter, Pin-Lan Li
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1080-1090 (2017)
The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome has been implicated in podocyte injury and glomerular sclerosis during hyperhomocysteinemia (hHcys). However, it remains unclear whether the NL
Externí odkaz:
https://doaj.org/article/3507410f75844f70af722746df835919