Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Owain W, Howell"'
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108670- (2024)
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with P
Externí odkaz:
https://doaj.org/article/cc11eaec18cb42d988985f04f6f16725
Autor:
Rhian Evans, Lewis M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. Neal, Owain W. Howell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and wi
Externí odkaz:
https://doaj.org/article/96a8f935c0644fc9baef94130d00bb8b
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101896- (2022)
Summary: We describe a modified BaseScope™ Assay protocol (ACDBio) for RNA in situ hybridization on fixed-frozen human brain tissue. The original protocol caused tissue detachment due to harsh tissue pre-treatment. We therefore optimized it to impr
Externí odkaz:
https://doaj.org/article/156ef02bc0f045ef8a98e6ab9bd81268
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2604 (2022)
Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system (CNS). The most common form of MS is a relapsing–remitting disease characterised by acute episodes of demyelination associated with the break
Externí odkaz:
https://doaj.org/article/b20ed4a11077448a8ce62ee1d55bebf2
Autor:
Philip Höflinger, Stefan Hauser, Eylan Yutuc, Holger Hengel, Lauren Griffiths, Florentine Radelfahr, Owain W. Howell, Yuqin Wang, Sonja L. Connor, P. Barton Duell, Andrea E. DeBarber, Peter Martus, Dieter Lütjohann, William J. Griffiths, Ludger Schöls
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100078- (2021)
Cerebrotendinous xanthomatosis (CTX) is caused by autosomal recessive loss-of-function mutations in CYP27A1, a gene encoding cytochrome p450 oxidase essential for bile acid synthesis, resulting in altered bile acid and lipid metabolism. Here, we aime
Externí odkaz:
https://doaj.org/article/41d7e6fd58f7466ca39ad0e0f6bfc8e4
Autor:
Patricia Gallego-Delgado, Rachel James, Eleanor Browne, Joanna Meng, Swetha Umashankar, Li Tan, Carmen Picon, Nicholas D Mazarakis, A Aldo Faisal, Owain W Howell, Richard Reynolds
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001008 (2020)
Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, wit
Externí odkaz:
https://doaj.org/article/af2cd0c7ca3a4e8d88ba7f3fe0e37a65
Autor:
Roberta Magliozzi, Giulia Fadda, Robert A. Brown, Amit Bar‐Or, Owain W. Howell, Simon Hametner, Damiano Marastoni, Alberto Poli, Richard Nicholas, Massimiliano Calabrese, Salvatore Monaco, Richard Reynolds
Publikováno v:
Annals of Neurology. 92:670-685
Leptomeningeal and perivenular infiltrates are important contributors to cortical grey matter damage and disease progression in multiple sclerosis (MS). Whereas perivenular inflammation induces vasculocentric lesions, leptomeningeal involvement follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1274b21ccf2d8137ff1243a73d10a6a7
https://doi.org/10.1002/ana.26448
https://doi.org/10.1002/ana.26448
Autor:
Roberta Magliozzi, Richard Reynolds, Camilla Reali, Richard Nicholas, Federico Roncaroli, Owain W. Howell
Publikováno v:
Reali, C, Magliozzi, R, Roncaroli, F, Nicholas, R, Howell, O W & Reynolds, R 2020, ' B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis ', Brain Pathology . https://doi.org/10.1111/bpa.12841
Brain Pathology
Brain Pathology
Increased inflammation in the cerebral meninges is associated with extensive subpial cortical grey matter pathology in the forebrain and a more severe disease course in a substantial proportion of secondary progressive multiple sclerosis (SPMS) cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80335bce4b61e1915d57b2251f35cbc
https://doi.org/10.1111/bpa.12841
https://doi.org/10.1111/bpa.12841
Autor:
Eylan Yutuc, Irina A. Pikuleva, Natalia Mast, Mark Baumert, Malcolm R. Clench, David O. F. Skibinski, Yuqin Wang, Roberto Angelini, Jillian Newton, Owain W. Howell, William J. Griffiths
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The brain is a remarkably complex organ and cholesterol homeostasis underpins brain function. It is known that cholesterol is not evenly distributed across different brain regions; however, the precise map of cholesterol metabolism in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03763b34c9f2c13ea7de23dc9e804d3
https://doi.org/10.1073/pnas.1917421117
https://doi.org/10.1073/pnas.1917421117