Zobrazeno 1 - 10 of 178 pro vyhledávání: '"Ovine Submaxillary Mucin"'
1
Purified human anti-Tn and anti-T antibodies specifically recognize carcinoma tissues
Autor: Ricardo D. Lardone, Yohana Camila Garay, Fernando J. Irazoqui, Verónica Maria Grupe, Natacha Zlocowski, Gustavo A. Nores
Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Described in several epithelial cancer cells, Tn- (GalNAcα1-O-Ser/Thr) and T- (Galβ3GalNAcα1-O-Ser/Thr) antigens are examples of tumor-associated antigens. Increased expression of Tn- and T-antigens is associated with tumor invasion and metastasis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d687393f23c8caaaf4b2e6e0a6fd1406
https://pubmed.ncbi.nlm.nih.gov/31147593
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2
ISOLATION and CHARACTERIZATION OF PEPTIDES PRODUCED BY THE MILD ACID HYDROLYSIS OF BOVINE SUBMAXILLARY MUCIN*
Autor: Fred Downs, Ward Pigman
Publikováno v: International Journal of Protein Research. 2:27-36
The rate of release of amino acids during partial acid hydrolysis of bovine submaxillary mucin has been studied. A number of di- and tripeptides have been isolated on the amino acid analyzer. Three β-hydroxyamino acid peptides, Thr-Thr-Thr, Ser-Ser,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc14981a28ae1a31dde27e2c4fcf6bd3
https://doi.org/10.1111/j.1399-3011.1970.tb01657.x
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4
Immunization of High-Risk Breast Cancer Patients with Clustered sTn-KLH Conjugate plus the Immunologic Adjuvant QS-21
Autor: R. Rao Koganty, Teresa Gilewski, Maura N. Dickler, Clifford A. Hudis, Alan N. Houghton, K. Panageas, Sonal Bhuta, Larry Norton, Govind Ragupathi, Philip O. Livingston, Jeannette Chin-Eng, Shemeeakah Powell
Publikováno v: Clinical Cancer Research. 13:2977-2985
Purpose: To determine the clinical toxicities and antibody response against sTn and tumor cells expressing sTn following immunization of high-risk breast cancer patients with clustered sTn-KLH [sTn(c)-KLH] conjugate plus QS-21.Experimental Design: Tw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7974667889d2751bfc43654177fe5e2
https://doi.org/10.1158/1078-0432.ccr-06-2189
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5
Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions
Autor: Joy Burchell, C. Fred Brewer, Kristin E. Haugstad, Gianfranco Picco, Bjørn T. Stokke, Soosan Hadjialirezaei, Marit Sletmoen, Thomas A. Gerken
Publikováno v: Glycobiology. 26(12)
The molecular mechanism(s) underlying the enhanced self-interactions of mucins possessing the Tn (GalNAcα1-Ser/Thr) or STn (NeuNAcα2-6GalNAcα1-Ser/Thr) cancer markers were investigated using optical tweezers (OT). The mucins examined included modi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc3673c366f9a973f25455945c465ed
https://pubmed.ncbi.nlm.nih.gov/27282157
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6
SialylTn-mAb17-1A Carbohydrate−Protein Conjugate Vaccine: Effect of Coupling Density and Presentation of SialylTn
Autor: Geert C. Mudde, Hans Loibner, Ralf Kircheis, Petra Vondru, Renate Ohler, Gottfried Himmler, Andreas Nechansky
Publikováno v: Bioconjugate Chemistry. 16:1519-1528
Carbohydrate antigens resulting from aberrant glycosylation of tumor cells, such as SialylTn, represent attractive targets for cancer vaccination. However, T-cell-independent carbohydrate antigens are poorly immunogenic and fail to induce memory and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfefbaa6c7b588e018c6718d51891cce
https://doi.org/10.1021/bc050157m
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7
Monoclonal Antibodies against the Tn-Specific Isolectin B4 fromVicia villosaSeeds: Characterization of the Epitope of the Blocking Antibody VV34
Autor: Ana Gimenez, Nora Berois, Andrea Medeiros, Eduardo Osinaga, Henia Balter, Ana Robles, Juan J. Calvete, Enrique Pérez-Payá
Publikováno v: Hybridoma and Hybridomics. 23:39-44
Vicia villosa isolectin B4 (VVLB4) recognizes the Tn antigen (GalNAc-O-Ser/Thr) exposed in certain human carcinomas. We have produced anti-VVLB4 monoclonal antibodies (MAbs), and their lectin recognition selectivity was assessed by ELISA and Western
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b2afcb5401eb5ab122b83bf8a9879b
https://doi.org/10.1089/153685904322772015
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8
An O-Acetylated Sialyl-Tn Is Involved in Ovarian Cancer-Associated Antigenicity
Autor: Mari Tenno, Akira Kurosaka, Shinya Toba
Publikováno v: Biochemical and Biophysical Research Communications. 271:281-286
We reported previously that a monoclonal antibody, 6G9, raised against bovine submaxillary mucin (BSM) reacted with mucinous ovarian cancer and recognized tumor-associated sialylated carbohydrate antigens. To obtain structural information on the carb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d24363ba66dcfa5493157f79a1698c
https://doi.org/10.1006/bbrc.2000.2618
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9
Redefined Substrate Specificity of ST6GalNAc II: A Second Candidate Sialyl-Tn Synthase
Autor: Shou Takashima, Shin-Ichiro Nishimura, Mari Kono, Shunichiro Ogata, Hong Liu, Shuichi Tsuji, Tetsuro Tsuda, Toshiro Hamamoto, Steven H. Itzkowitz
Publikováno v: Biochemical and Biophysical Research Communications. 272:94-97
The acceptor substrate specificities of ST6GalNAc I and II, which act on the synthesis of O-linked oligosaccharides, were reexamined using ovine submaxillary mucin, [Ala-Thr(GalNAc)-Ala] n polymer ( n = 7–11). It has been suggested that only ST6Gal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c4beb7e53c71c7b5621b81bb111104
https://doi.org/10.1006/bbrc.2000.2745
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10
Lectin from Beauveria bassiana mycelium recognizes Thomsen–Friedenreich antigen and related structures
Autor: Iwona Kątnik-Prastowska, Mariusz Olczak, Eliza Lamer-Zarawska, Barbara Kossowska
Publikováno v: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 123:23-31
A lectin was isolated from the mycelium of the stationary growing enthomopathogenic fungus Beauveria bassiana by extraction, chromatography on QAE-Sephadex A-25, salt precipitation, and hydrophobic chromatography on Phenyl-Sepharose 4B. The Beauveria
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c14ea2d3c4976ffe51b1551cb87eb6
https://doi.org/10.1016/s0305-0491(99)00036-x
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