Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Ovidiu Radulescu"'
Autor:
Maëlle Bellec, Jérémy Dufourt, George Hunt, Hélène Lenden-Hasse, Antonio Trullo, Amal Zine El Aabidine, Marie Lamarque, Marissa M. Gaskill, Heloïse Faure-Gautron, Mattias Mannervik, Melissa M. Harrison, Jean-Christophe Andrau, Cyril Favard, Ovidiu Radulescu, Mounia Lagha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Using quantitative imaging and monitoring transcription in living embryos, Bellec et al., provide evidence that the pioneer factor GAF acts as a stable mitotic bookmarker during early Drosophila development.
Externí odkaz:
https://doaj.org/article/80b25a724980469e83291c0573c05048
Publikováno v:
Viruses, Vol 15, Iss 9, p 1969 (2023)
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1 latency, which were possible in a large part due to the development of single-cell approaches. HIV-1 transcription proceeds in bursts of RNA production, whi
Externí odkaz:
https://doaj.org/article/9505ab18bace4596861c52e4972fd576
Autor:
Katjana Tantale, Encar Garcia-Oliver, Marie-Cécile Robert, Adèle L’Hostis, Yueyuxiao Yang, Nikolay Tsanov, Rachel Topno, Thierry Gostan, Alja Kozulic-Pirher, Meenakshi Basu-Shrivastava, Kamalika Mukherjee, Vera Slaninova, Jean-Christophe Andrau, Florian Mueller, Eugenia Basyuk, Ovidiu Radulescu, Edouard Bertrand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a
Externí odkaz:
https://doaj.org/article/07173f9934654a55b481d64dbbdee8ab
Autor:
Virginia L. Pimmett, Matthieu Dejean, Carola Fernandez, Antonio Trullo, Edouard Bertrand, Ovidiu Radulescu, Mounia Lagha
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here the authors decode how core promoter elements regulate rate limiting steps of transcription using quantitative live imaging, genetics and modeling in early Drosophila embryos. TATA-driven promoters require one rate-limiting step while INR promot
Externí odkaz:
https://doaj.org/article/55b0451fd1cf4e94bb3a8c2e059b2a51
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cutaneous melanoma is a highly invasive tumor and, despite the development of recent therapies, most patients with advanced metastatic melanoma have a poor clinical outcome. The most frequent mutations in melanoma affect the BRAF oncogene, a protein
Externí odkaz:
https://doaj.org/article/f65e8c571eab4028a31e0365483a05ab
Autor:
Jeremy Dufourt, Antonio Trullo, Jennifer Hunter, Carola Fernandez, Jorge Lazaro, Matthieu Dejean, Lucas Morales, Saida Nait-Amer, Katharine N. Schulz, Melissa M. Harrison, Cyril Favard, Ovidiu Radulescu, Mounia Lagha
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Zelda is a pioneer factor that regulates transcription in Drosophila embryos. Here, the authors use quantitative live imaging and mathematical modeling to measure the effect of Zelda on transcriptional dynamics and memory, observing temporal control
Externí odkaz:
https://doaj.org/article/6f73d116eb0e46649c4a65fbc2648168
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007497 (2019)
Organisms must ensure that expression of genes is directed to the appropriate tissues at the correct times, while simultaneously ensuring that these gene regulatory systems are robust to perturbation. This idea is captured by a mathematical concept c
Externí odkaz:
https://doaj.org/article/39131be75cac4ee79bc8de2b37837bfd
Autor:
Marion Buffard, Aurélien Naldi, Gilles Freiss, Marcel Deckert, Ovidiu Radulescu, Peter J. Coopman, Romain M. Larive
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 308 (2021)
Spleen tyrosine kinase (SYK) can behave as an oncogene or a tumor suppressor, depending on the cell and tissue type. As pharmacological SYK inhibitors are currently evaluated in clinical trials, it is important to gain more information on the molecul
Externí odkaz:
https://doaj.org/article/f0455d20d1d745b19f102be60f38537d
Publikováno v:
Frontiers in Physics, Vol 6 (2018)
We discuss piecewise-deterministic approximations of gene networks dynamics. These approximations capture in a simple way the stochasticity of gene expression and the propagation of expression noise in networks and circuits. By using partial omega ex
Externí odkaz:
https://doaj.org/article/abff02fb03ce40bcb804f4c5f6b06b3c
Autor:
Aurélien Naldi, Romain M Larive, Urszula Czerwinska, Serge Urbach, Philippe Montcourrier, Christian Roy, Jérôme Solassol, Gilles Freiss, Peter J Coopman, Ovidiu Radulescu
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005432 (2017)
The ability to build in-depth cell signaling networks from vast experimental data is a key objective of computational biology. The spleen tyrosine kinase (Syk) protein, a well-characterized key player in immune cell signaling, was surprisingly first
Externí odkaz:
https://doaj.org/article/d46dc81fb6aa402d9f040f85e90fefd8