Functional characteristics and computational model of abundant hyperactive loci in the human genome.

Autor: Hudaiberdiev S; National Institute for Biotechnology and Information, National Library of Medicine, National Institutes of Health, Bethesda, United States., Ovcharenko I; National Institute for Biotechnology and Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.

Publikováno v: ELife [Elife] 2024 Nov 13; Vol. 13. Date of Electronic Publication: 2024 Nov 13.

Detection of new pioneer transcription factors as cell-type-specific nucleosome binders.

Autor: Peng Y; Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan, China.; National Library of Medicine, National Institutes of Health, Bethesda, United States., Song W; National Library of Medicine, National Institutes of Health, Bethesda, United States., Teif VB; School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, United Kingdom., Ovcharenko I; National Library of Medicine, National Institutes of Health, Bethesda, United States., Landsman D; National Library of Medicine, National Institutes of Health, Bethesda, United States., Panchenko AR; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada.; Department of Biology and Molecular Sciences, Queen's University, Kingston, Canada.; School of Computing, Queen's University, Kingston, Canada.; Ontario Institute of Cancer Research, Toronto, Canada.

Publikováno v: ELife [Elife] 2024 Jan 31; Vol. 12. Date of Electronic Publication: 2024 Jan 31.

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.

Autor: Hudaiberdiev S; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20892., Taylor DL; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Song W; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20892., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Bhuiyan RM; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT 06032., Taylor HJ; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Tang X; Department of Surgery, Weill Cornell Medicine, New York, NY 10065.; Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065., Yan T; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Swift AJ; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Consortium D, Chen S; Department of Surgery, Weill Cornell Medicine, New York, NY 10065.; Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065., Stitzel ML; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT 06032.; Institute of Systems Genomics, University of Connecticut, Farmington, CT 06032., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892., Ovcharenko I; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20892., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug 29; Vol. 120 (35), pp. e2206612120. Date of Electronic Publication: 2023 Aug 21.

De novo human brain enhancers created by single-nucleotide mutations.

Autor: Li S; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA.; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hannenhalli S; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Ovcharenko I; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA.

Publikováno v: Science advances [Sci Adv] 2023 Feb 15; Vol. 9 (7), pp. eadd2911. Date of Electronic Publication: 2023 Feb 15.

Heterogeneity of enhancers embodies shared and representative functional groups underlying developmental and cell type-specific gene regulation.

Autor: Song W; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. Electronic address: wei.song@nih.gov., Ovcharenko I; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. Electronic address: ovcharen@nih.gov.

Publikováno v: Gene [Gene] 2022 Aug 05; Vol. 834, pp. 146640. Date of Electronic Publication: 2022 Jun 06.