Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Ovanes G. Mekenyan"'
Autor:
Atanas Chapkanov, Terry W. Schultz, Darina Yordanova, Kalin Kirilov, Hristiana Ivanova, Ovanes G. Mekenyan
Publikováno v:
Regulatory Toxicology and Pharmacology. 139:105357
Autor:
Atanas Chapkanov, Louise Camenzuli, Todor Pavlov, Ovanes G. Mekenyan, Timothy J. Patterson, Darina Yordanova, Colin M. North
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 40(11)
Many of the newly produced and registered substances are complex mixtures or substances of unknown or variable composition, complex reaction products, and biological materials (UVCBs). The latter often consist of a large number of constituents, some
Autor:
Todor Pavlov, Atanas Chapkanov, Marin Georgiev, Ovanes G. Mekenyan, Andrea Gissi, Chanita Kuseva, Georgi Chankov, Hristiana Ivanova, Darina Yordanova, Tomasz Sobanski, Terry W Schultz, Ksenia Tankova
Publikováno v:
Computational Toxicology. 11:65-71
Read-across is an alternative or supplementary method to the use of test results (including test results from tests employing laboratory animals) for chemical hazard assessment. Its use by both the industrial and the regulatory communities has increa
Autor:
Tomasz Sobanski, Marin Georgiev, Atanas Chapkanov, Chanita Kuseva, Ksenia Tankova, Todor Pavlov, Terry W Schultz, Stela Kutsarova, Ovanes G. Mekenyan, Darina Yordanova, Andrea Gissi
Publikováno v:
Regulatory Toxicology and Pharmacology. 105:51-61
The Read-Across Assessment Framework (RAAF) was developed by the European Chemicals Agency (ECHA) as an internal tool providing a framework for a consistent, structured and transparent assessment of grouping of chemicals and read-across. Following a
Autor:
Stanislav Temelkov, Chanita Kuseva, Irina Dermen, Darina Yordanova, Marin Georgiev, Ksenia Tankova, Andrea Gissi, Atanas Chapkanov, Tomasz Sobanski, Hristiana Ivanova, Todor Pavlov, Ovanes G. Mekenyan, Terry W Schultz
Publikováno v:
Computational Toxicology. 10:89-104
Toxicological understanding and computational possibilities progress every year. The OECD QSAR Toolbox, an in silico system for predicting toxicity of chemicals, is regularly updated with up to data knowledge and functionalities. This expansion has m
Autor:
Todor Pavlov, Terry W Schultz, Georgi Chankov, Yordan H. Karakolev, Tomasz Sobanski, Ovanes G. Mekenyan, Chanita Kuseva, Andrea Gissi, Hristiana Ivanova, Darina Yordanova
Publikováno v:
Computational Toxicology. 10:26-37
Both industry and regulatory agencies use structure-activity relationships and read-across as toxicity assessment methods alternative to animal experimentation. A prerequisite for acceptance of the outcome of such in silico predictions is establishin
Autor:
Irina A. Dermen, Hristiana I. Ivanova, Elena K. Kaloyanova, Nadezhda H. Dimitrova, Antonia D. Kesova, Todor S. Pavlov, Terry W. Schultz, Ovanes G. Mekenyan
Publikováno v:
Computational Toxicology. 22:100218
Publikováno v:
Computational Toxicology. 22:100219
Autor:
Ovanes G. Mekenyan, Takashi Yamada, Elena Kaloyanova, Petko I. Petkov, Masamitsu Honma, Terry W Schultz
Publikováno v:
Mutagenesis. 34:83-90
This study validates the performance of the TIssue MEtabolism Simulator (TIMES) genotoxicity models with data on pesticide chemicals included in a recently released European Food Safety Authority (EFSA) genotoxicity database. The EFSA database is bia
Autor:
Darina Yordanova, Stela Kutsarova, Chanita Kuseva, Ovanes G. Mekenyan, Stoyanka Stoeva, Aycel Mehmed, Atanas Chapkanov, Todor Petkov, Terry W Schultz, Daniela Cherkezova, Marin Georgiev
Publikováno v:
Computational Toxicology. 20:100194
As modules in the QSAR Toolbox become automated, operator control is diminished. Therefore, it becomes more crucial that evidence be provided that reveals the software meets the specification intended by the developers (i.e., verification) and the re