Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Outi Villet"'
Autor:
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the mechanistic link to macr
Externí odkaz:
https://doaj.org/article/e3581f7d6a324f0087a40889fbd6dc76
Autor:
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C. Kolwicz Jr., Wang Wang, James E. Bruce, Rong Tian
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for the switch are
Externí odkaz:
https://doaj.org/article/42430db1c8a448f4bb8c08df2e4cb07e
Autor:
Matthew A. Walker, Juan Chavez, Outi Villet, Xiaoting Tang, Andrew Keller, James E. Bruce, Rong Tian
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively co
Externí odkaz:
https://doaj.org/article/38a7738718cd42c8bbb9eef873beabad
Autor:
Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz, Daniel Raftery, Rong Tian
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino ac
Externí odkaz:
https://doaj.org/article/3d416561e0a045b687c31a78486d0513
Autor:
Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Andrew Keller, Jared P. Mohr, Anna A. Bakhtina, Outi Villet, Hongye Chen, Bo Zhou, Matthew A. Walker, Rong Tian, James E. Bruce
Publikováno v:
Nat Cardiovasc Res
Advancements in cross-linking mass spectrometry (XL-MS) bridge the gap between purified systems and native tissue environments, allowing the detection of protein structural interactions in their native state. Here we use isobaric quantitative protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cb3fab22a0f6936441a8653a85a72d
https://pubmed.ncbi.nlm.nih.gov/36405497
https://pubmed.ncbi.nlm.nih.gov/36405497
Autor:
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Publikováno v:
The Journal of clinical investigation.
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the mechanistic link to macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46c8ad2db9f69f90e868d2f1e29876c
https://pubmed.ncbi.nlm.nih.gov/36480284
https://pubmed.ncbi.nlm.nih.gov/36480284
Publikováno v:
J Mol Cell Cardiol
High fatty acid oxidation (FAO) is associated with lipotoxicity, but whether it causes lipotoxic cardiomyopathy remains controversial. Molecular mechanisms that may be responsible for FAO-induced lipotoxic cardiomyopathy are also elusive. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce21b13a331fd7f05141d9ebd72d572
https://doi.org/10.1016/j.yjmcc.2020.06.008
https://doi.org/10.1016/j.yjmcc.2020.06.008
Autor:
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C. Kolwicz, Wang Wang, James E. Bruce, Rong Tian
Publikováno v:
The Journal of clinical investigation. 132(10)
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the expense of ATP production. Mechanisms responsible for the switch are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11e22e9a38a1990c19e251b6956cfb5
https://pubmed.ncbi.nlm.nih.gov/35575090
https://pubmed.ncbi.nlm.nih.gov/35575090
Autor:
Matthew A. Walker, James E. Bruce, Bo Zhou, Arianne Caudal, Andrew Keller, Juan D. Chavez, Rong Tian, Xiaoting Tang, Outi Villet
Advancements of cross-linking mass spectrometry (XL-MS) for structural analysis of proteins bridges the gap between purified systems and native tissue environments. Here, isobaric quantitative protein interaction reporter technology (iqPIR) was utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f954f2360c3bf080119ed70fe877d9
https://doi.org/10.1101/2021.08.13.456027
https://doi.org/10.1101/2021.08.13.456027
Autor:
Outi Villet, Sara Young, Stephen C. Kolwicz, Arianne Caudal, Julia Ritterhoff, Rong Tian, Taurence Senn, Timothy S. McMillen
Publikováno v:
J Mol Cell Cardiol
Background Reduced fatty acid oxidation (FAO) is a hallmark of metabolic remodeling in heart failure. Enhancing mitochondrial long-chain fatty acid uptake by Acetyl-CoA carboxylase 2 (ACC2) deletion increases FAO and prevents cardiac dysfunction duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f27004678a761a0bfc2a768eda49fa1
https://europepmc.org/articles/PMC8405556/
https://europepmc.org/articles/PMC8405556/