Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Outi Rautsi"'
Publikováno v:
BioTechniques, Vol 40, Iss 5, Pp 573-576 (2006)
Externí odkaz:
https://doaj.org/article/d37a346410bf4a639a5fbb93bcc7f703
Autor:
Outi Rautsi, Mattias Hällbrink, Maarja Mäe, Maria Lindgren, Pirjo Laakkonen, Katri Rosenthal Aizman, Ülo Langel, Juulia Enbäck
Publikováno v:
International Journal of Peptide Research and Therapeutics. 18:361-371
Cell-penetrating peptides (CPPs) are short transport peptides with a well-established ability for delivery of bioactive cargoes inside the cells both, in vitro and in vivo. CPPs enter unselectively in a wide variety of cell lines, this is a desirable
Autor:
Ari Hinkkanen, Jarmo Wahlfors, Outi Rautsi, Markus Vähä-Koskela, Juhana M. Hakumäki, Thomas Wirth, Tiina Wahlfors, Ann-Marie Määttä, Katja Häkkinen, Linda C. Jansson, Piia Valonen, Kimmo Mäkinen, Riikka Pellinen, Timo Liimatainen
Publikováno v:
International Journal of Cancer. 121:863-870
Semliki Forest virus (SFV) is one of the latest candidates for a virotherapeutic agent against cancer, and recent studies have demonstrated its efficacy in tumor models. In the present study, we examined the antitumor efficacy of an avirulent SFV str
Autor:
Ann-Marie Määttä, Riikka Pellinen, Jarmo Wahlfors, Outi Rautsi, Anna Ketola, Kimmo Mäkinen, Markus Vähä-Koskela, Timo Liimatainen, Risto Pirinen, Ari Hinkkanen, Felicitas Yongabi
Publikováno v:
International journal of cancer. 123(7)
We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We hav
Autor:
Jarmo Wahlfors, Outi Rautsi, Ann-Marie Määttä, Riikka Pellinen, Saara Lehmusvaara, Anna Ketola
Publikováno v:
Cancer gene therapy. 15(5)
Cancer suicide gene therapy based on herpes simplex virus type I thymidine kinase (HSV-TK) and ganciclovir (GCV) suffers from the lack of efficacy in clinical use, which is mostly due to low gene-transfer efficiency and absence of bystander effect in
Autor:
Outi Rautsi, Riikka Pellinen, Maarit Sillanpää, Tuula Salonen, Katja Häkkinen, Saara Lehmusvaara, Ilkka Julkunen, Tanja Hakkarainen, Seppo Ylä-Herttuala, Jarmo Wahlfors, Ari Hinkkanen, Elisa Vähäkangas, Sami Heikkinen
Publikováno v:
The journal of gene medicine. 9(2)
Background Type I interferon (IFN-α/β) response is one of the major host defence mechanisms against viruses. Some recent reports suggest that IFNs may interfere with the efficacy of both non-viral and virus-vector-mediated therapeutic gene transfer
Publikováno v:
BioTechniques. 40(5)
Autor:
Jarmo Wahlfors, Eveliina Pasanen, Saara Lehmusvaara, Outi Rautsi, Marika Ruponen, Tanja Hakkarainen
Publikováno v:
Molecular Therapy. 13
The enhancing effect of cell-permeable peptides and polycations to virus-mediated gene transfer was investigated by transducing different cell lines with virus-polycation complexes. In addition, blocking of intracellular polyamine production with def
Autor:
Ylä-herttuala Seppo, Riikka Pellinen, Outi Rautsi, Hakkarainen Tanja, Sillanpää Maarit, Wahlfors Jarmo, Julkunen Ilkka, Vähäkangas Elisa, Hinkkanen Ari, Saara Lehmusvaara
Publikováno v:
Molecular Therapy. 13
The first barrier that therapeutic gene transfer confronts is the target cells' early line of defense, the type I IFN response. Often therapeutic genes are delivered with viral vectors that are in many ways superior to their non- viral counterparts.