Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Outi Hovatta"'
Autor:
Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but
Externí odkaz:
https://doaj.org/article/e6b0eb324cf54b6ca3c0777743fe76df
Autor:
Lynn Yap, Jiong-Wei Wang, Aida Moreno-Moral, Li Yen Chong, Yi Sun, Nathan Harmston, Xiaoyuan Wang, Suet Yen Chong, Konstantinos Vanezis, Miina K. Öhman, Heming Wei, Ralph Bunte, Sujoy Gosh, Stuart Cook, Outi Hovatta, Dominique P.V. de Kleijn, Enrico Petretto, Karl Tryggvason
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Externí odkaz:
https://doaj.org/article/37c7a1f9dfd94358bbc5a5cad4241152
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
The Karolinska Institutet Human Embryonic Stem Cell Bank (KI Stem Cell Bank) was established at KI, Stockholm, Sweden, when the first human embryonic stem cell (hESC) line was derived by Professor Hovatta and colleagues in 2002. Since then, the bank
Externí odkaz:
https://doaj.org/article/d2f8f61829a3437e87a3b1cd2e4b7cb4
Autor:
Riikka J. Lund, Nelly Rahkonen, Maia Malonzo, Leni Kauko, Maheswara Reddy Emani, Virpi Kivinen, Elisa Närvä, Esko Kemppainen, Asta Laiho, Heli Skottman, Outi Hovatta, Omid Rasool, Matti Nykter, Harri Lähdesmäki, Riitta Lahesmaa
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1442-1454 (2017)
POLR3G is expressed at high levels in human pluripotent stem cells (hPSCs) and is required for maintenance of stem cell state through mechanisms not known in detail. To explore how POLR3G regulates stem cell state, we carried out deep-sequencing anal
Externí odkaz:
https://doaj.org/article/f5149f7793d441839007ecae5f814030
Autor:
Lynn Yap, Jiong-Wei Wang, Aida Moreno-Moral, Li Yen Chong, Yi Sun, Nathan Harmston, Xiaoyuan Wang, Suet Yen Chong, Miina K. Öhman, Heming Wei, Ralph Bunte, Sujoy Gosh, Stuart Cook, Outi Hovatta, Dominique P.V. de Kleijn, Enrico Petretto, Karl Tryggvason
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3231-3245.e9 (2019)
Summary: Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical-quality stem cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221
Externí odkaz:
https://doaj.org/article/5528036c24444c48b01a49e6d7a417bd
Autor:
Mien T.X. Nguyen, Elena Okina, Xiaoran Chai, Kok Hian Tan, Outi Hovatta, Sujoy Ghosh, Karl Tryggvason
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 802-816 (2016)
A major hurdle for in vitro culturing of primary endothelial cells (ECs) is that they readily dedifferentiate, hampering their use for therapeutic applications. Human embryonic stem cells (hESCs) may provide an unlimited cell source; however, most cu
Externí odkaz:
https://doaj.org/article/cc690d9b27db42ca8ede82019d996c2c
Autor:
Alvaro Plaza Reyes, Sandra Petrus-Reurer, Liselotte Antonsson, Sonya Stenfelt, Hammurabi Bartuma, Sarita Panula, Theresa Mader, Iyadh Douagi, Helder André, Outi Hovatta, Fredrik Lanner, Anders Kvanta
Publikováno v:
Stem Cell Reports, Vol 6, Iss 1, Pp 9-17 (2016)
Human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells could replace lost tissue in geographic atrophy (GA) but efficacy has yet to be demonstrated in a large-eyed model. Also, production of hESC-RPE has not yet been achieved
Externí odkaz:
https://doaj.org/article/20e1e75292c84e5384a548b32ba04960
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1028 (2020)
Globally, fertility-related issues affect around 15% of couples. In 20%−30% of cases men are solely responsible, and they contribute in around 50% of all cases. Hence, understanding of in vivo germ-cell specification and exploring different angles
Externí odkaz:
https://doaj.org/article/26d1f34dc0fd4a11bd72d8d560dc0b1a
Autor:
Halima Albalushi, Magdalena Kurek, Leif Karlsson, Luise Landreh, Kristín Rós Kjartansdóttir, Olle Söder, Outi Hovatta, Jan-Bernd Stukenborg
Publikováno v:
Stem Cells International, Vol 2018 (2018)
Human embryonic stem (hES) cells represent an important tool to study early cell development. The previously described use of human recombinant laminin (LN) 521 represented a step forward in generating clinically safe culture conditions. To test the
Externí odkaz:
https://doaj.org/article/6452a9331bd54054b0e10cdbfab01411
Autor:
Chang Yin, Temesgen Fufa, Gayathri Chandrasekar, Madhu Aeluri, Verina Zaky, Shaimaa Abdelhady, Antonio B. Rodríguez, Johan Jakobsson, Farzaneh Shahin Varnoosfaderani, Jayashri Mahalingam, Jianping Liu, Olle Larsson, Outi Hovatta, Frank Gaunitz, Anita Göndör, Michael Andäng, Satish S. Kitambi
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach u
Externí odkaz:
https://doaj.org/article/92b21c9fe7724cbb9f73f8be6d34d7ce