Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Outflow tract morphogenesis"'
Publikováno v:
Development (Cambridge, England). 146(13)
During embryogenesis, epithelial organization is the prerequisite for organogenesis, in particular, for establishing the tubular structure. Recent studies provided hints about epithelial formation in early heart development, which has not been system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbfb8b6d31d41f547e62f7295388651
https://pubmed.ncbi.nlm.nih.gov/31201155
https://pubmed.ncbi.nlm.nih.gov/31201155
Publikováno v:
Developmental Biology. 370(1):135-144
Disheveled (Dvl) is a key regulator of both the canonical Wnt and the planar cell polarity (PCP) pathway. Previous genetic studies in mice indicated that outflow tract (OFT) formation requires Dvl1 and 2, but it was unclear which pathway was involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6101de42fee7b718b601baff969fb7
Autor:
Brigitte Laforest, Mona Nemer
Publikováno v:
Developmental Biology. 358:368-378
Members of the GATA family of transcription factors are critical regulators of heart development and mutations in 2 of them, GATA4 and GATA6 are associated with outflow tract and septal defects in human. The heart expresses 3 GATA factors, GATA4, 5 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77d95857e2a4a02a59cfb7b6cadeaad
https://doi.org/10.1016/j.ydbio.2011.07.037
https://doi.org/10.1016/j.ydbio.2011.07.037
Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis
Autor:
Jeremy L. Barth, Benjamin Lee, Kyu-Ho Lee, Ellen P. Knoll, Victor M. Fresco, W. Scott Argraves, Christopher D. Clark
Publikováno v:
Developmental Dynamics. 239:2024-2033
Nkx2.5, a transcription factor implicated in human congenital heart disease, is required for regulation of second heart field (SHF) progenitors contributing to outflow tract (OFT). Here, we define a set of genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d1c4e2ed87d7139e2bcf40178dddae
https://doi.org/10.1002/dvdy.22341
https://doi.org/10.1002/dvdy.22341
Autor:
Sophia E. Troy, Marthe J. Howard, Kristen L. Holler, Joshua W. Vincentz, Anthony B. Firulli, Tyler J. Hendershot
Publikováno v:
Developmental Biology. 341:291-304
The basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac development both in neural crest-derived and mesoderm-derived structures. Targeted deletion of Hand2 in the neural crest has allowed us to genetically dissect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149aadbafa3154a46ba9d96e17d1d741
https://doi.org/10.1016/j.ydbio.2010.02.001
https://doi.org/10.1016/j.ydbio.2010.02.001
miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation
Autor:
Ankur Saxena, Clifford J. Tabin
Publikováno v:
Proceedings of the National Academy of Sciences. 107:87-91
MicroRNAs (miRNAs) have previously been implicated in a number of developmental processes, including development of the ventricular myocardium of the heart. To determine what, if any, additional roles miRNAs play in cardiogenesis, we deleted the miRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1670b500cf505038d32b313d8e80eda
https://doi.org/10.1073/pnas.0912870107
https://doi.org/10.1073/pnas.0912870107
Autor:
Jue Zhang, Robert J. Schwartz, Yongshun Lin, Anne M. Moon, Yongsheng Lan, James F. Martin, Fen Wang, Chunhong Lin, Yongyou Zhang
Publikováno v:
Development. 135:3611-3622
The cardiac outflow tract (OFT) is a developmentally complex structure derived from multiple lineages and is often defective in human congenital anomalies. Although emerging evidence shows that fibroblast growth factor(FGF) is essential for OFT devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392d56ba31b97f0de5636ee28c84b89f
https://doi.org/10.1242/dev.025361
https://doi.org/10.1242/dev.025361
Publikováno v:
Developmental Biology. 308:421-437
Msx1 and Msx2 are highly conserved, Nk-related homeodomain transcription factors that are essential for a variety of tissue–tissue interactions during vertebrate organogenesis. Here we show that combined deficiencies of Msx1 and Msx2 cause conotrun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec7ff101aa411621d986f90cdf27161
https://doi.org/10.1016/j.ydbio.2007.05.037
https://doi.org/10.1016/j.ydbio.2007.05.037
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Epigenetics
instname
Epigenetics
Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely unknown. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09ee9988dff613f4d117e4e35c2b7cc
http://hdl.handle.net/10230/25933
http://hdl.handle.net/10230/25933
Autor:
Deborah U. Frank, Lisa A. Ogden, Brian L. Black, Amy Talbot, Anne M. Moon, Sylvia M. Evans, Chen-Leng Cai, Eon Joo Park
Publikováno v:
Development. 133:2419-2433
Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous temporospatial domains that are potentially relevant to cardiovascular development. However, the pathogenesis of complex cardiac and outflow tract defects observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d493087cd74adbd5d6b392814e2cb7a4
https://doi.org/10.1242/dev.02367
https://doi.org/10.1242/dev.02367