Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts.

Autor: Harding J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Vintersten-Nagy K; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Yang H; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Tang JK; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Shutova M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Jong ED; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Lee JH; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Massumi M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Oussenko T; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Izadifar Z; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Zhang P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Rogers IM; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada., Wheeler MB; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Toronto General Hospital Research Institute, Toronto, Ontario, Canada., Lye SJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada., Sung HK; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Li C; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Izadifar M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Nagy A; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. nagy@lunenfeld.ca.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. nagy@lunenfeld.ca.; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada. nagy@lunenfeld.ca.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia. nagy@lunenfeld.ca.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Apr; Vol. 8 (4), pp. 427-442. Date of Electronic Publication: 2023 Nov 23.

Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunity.

Autor: Tsuneyoshi, Norihiro¹ (AUTHOR), Hosoya, Tomonori¹ (AUTHOR), Takeno, Yuriko¹ (AUTHOR), Saitoh, Kodai¹ (AUTHOR), Murai, Hidetaka¹ (AUTHOR), Amimoto, Naoki¹ (AUTHOR), Tatsumi, Rie¹ (AUTHOR), Watanabe, Sono¹ (AUTHOR), Hasegawa, Yudai¹ (AUTHOR), Kikkawa, Eri¹ (AUTHOR), Goto, Kumiko¹ (AUTHOR), Nishigaki, Fusako¹ (AUTHOR), Tamura, Kouichi¹ (AUTHOR) k.tamura@healios.jp, Kimura, Hironobu¹ (AUTHOR) h.kimura@healios.jp

Publikováno v: Stem Cell Research & Therapy. 7/2/2024, Vol. 15 Issue 1, p1-20. 20p.

Engineering a humanized bone organ model in mice to study bone metastases.

Autor: Martine LC; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Holzapfel BM; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany., McGovern JA; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Wagner F; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Department of Orthopedics for the University of Regensburg, Asklepios Klinikum Bad Abbach, Bad Abbach, Germany.; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Quent VM; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Department of Obstetrics and Gynecology, Martin-Luther-Krankenhaus, Academic Teaching Hospital of the Charité Berlin, Berlin, Germany., Hesami P; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Wunner FM; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Vaquette C; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., De-Juan-Pardo EM; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Brown TD; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Nowlan B; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Wu DJ; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Hutmacher CO; Queensland University of Technology (QUT), Brisbane, Queensland, Australia., Moi D; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Oussenko T; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Piccinini E; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Zandstra PW; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Mazzieri R; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Lévesque JP; Stem Cell Biology Group - Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.; Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia., Dalton PD; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Department of Functional Materials in Medicine and Dentistry, and Bavarian Polymer Institute, University of Wuerzburg, Wuerzburg, Germany., Taubenberger AV; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; Biotec TU Dresden, Dresden, Germany., Hutmacher DW; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.; George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Institute for Advanced Study, Technical University Munich, Garching, Germany.

Publikováno v: Nature protocols [Nat Protoc] 2017 Apr; Vol. 12 (4), pp. 639-663. Date of Electronic Publication: 2017 Mar 02.

Breast Cancer Cells Metastasize to the Tissue-Engineered Premetastatic Niche by Using an Osteoid-Formed Polycaprolactone/Nanohydroxyapatite Scaffold.

Autor: Xiong, Qisheng^1,2 (AUTHOR), Wang, Meng^1,2 (AUTHOR), Liu, Jinglong^1,2 (AUTHOR), Lin, Chia-Ying^2,3 (AUTHOR)

Publikováno v: Computational & Mathematical Methods in Medicine. 12/13/2021, p1-13. 13p.

Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone.

Autor: Kähkönen, Tiina E.¹, Suominen, Mari I.¹, Mäki-Jouppila, Jenni H. E.¹, Halleen, Jussi M.¹, Tanaka, Azusa², Seiler, Michael², Bernoulli, Jenni¹

Publikováno v: Journal of Immunology Research. 5/9/2019, p1-10. 10p. 3 Graphs, 1 Map.