Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ourania N. Kostopoulou"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116993- (2024)
Aim: Neuroblastoma (NB) is, in spite of current intensive therapy with severe side effects, still not cured so new therapies are needed. Recently, we showed combining phosphoinositide 3-kinase (PI3K) (BYL719), fibroblast growth factor receptor (FGFR)
Externí odkaz:
https://doaj.org/article/7e09689e84ae4f11aba570785f98b76b
Autor:
Caroline Haglund de Flon, Linnea Haeggblom, Stefan Holzhauser, Ourania N. Kostopoulou, Mark Zupancic, Tina Dalianis, Eva Munck-Wikland, Linda Marklund, Anders Näsman
Publikováno v:
Cancers, Vol 15, Iss 7, p 1954 (2023)
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favourable prognosis. It has therefore been suggested that treatment should be individualized and separated by HPV status. However, additional prog
Externí odkaz:
https://doaj.org/article/3b9eecda8d1d471b977faaaab0a114bd
Autor:
Karin Byskata, Monika Lukoseviciute, Filippo Tuti, Mark Zupancic, Ourania N. Kostopoulou, Stefan Holzhauser, Tina Dalianis
Publikováno v:
Cancers, Vol 15, Iss 1, p 93 (2022)
Human papillomavirus positive (HPV+) tonsillar and base of tongue cancer (TSCC/BOTSCC) is rising in incidence, but chemoradiotherapy is not curative for all. Therefore, targeted therapy with PI3K (BYL719), PARP (BMN-673), and WEE1 (MK-1775) inhibitor
Externí odkaz:
https://doaj.org/article/84314589456b4bdd8d208cdca88983af
Autor:
Monika Lukoseviciute, Henrietta Maier, Eleni Poulou-Sidiropoulou, Erika Rosendahl, Stefan Holzhauser, Tina Dalianis, Ourania N. Kostopoulou
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ObjectivesMedulloblastoma (MB) is treated with surgery and chemotherapy, with or without irradiation, but unfortunately >20% of the patients are not cured, and treatment comes with serious long-term side effects, so novel treatments are urgently need
Externí odkaz:
https://doaj.org/article/8a7914929737482287a7f7ecd227847a
Autor:
Stefan Holzhauser, Nicole Wild, Mark Zupancic, Ramona G. Ursu, Cinzia Bersani, Anders Näsman, Ourania N. Kostopoulou, Tina Dalianis
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ObjectivesHuman papillomavirus positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC), the major subsites of oropharyngeal squamous cell carcinoma (OPSCC) have favorable outcome, but upon relapse, outcome is poor and new t
Externí odkaz:
https://doaj.org/article/0611b27538a9495c8d69f65dd2dc0ddd
Autor:
Ourania N. Kostopoulou, Mark Zupancic, Mariona Pont, Emma Papin, Monika Lukoseviciute, Borja Agirre Mikelarena, Stefan Holzhauser, Tina Dalianis
Publikováno v:
Viruses, Vol 14, Iss 7, p 1372 (2022)
Human papillomavirus positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have a favorable outcome, but upon relapse, survival is poor and new therapeutical options are needed. Recently, we found synergistic effects by c
Externí odkaz:
https://doaj.org/article/1a6c7b4e805d409e8b4d38f2c0389a37
Autor:
Anders Näsman, Stefan Holzhauser, Ourania N. Kostopoulou, Mark Zupancic, Andreas Ährlund-Richter, Juan Du, Tina Dalianis
Publikováno v:
Viruses, Vol 13, Iss 5, p 910 (2021)
The incidence of Human-papillomavirus-positive (HPV+) tonsillar and base-of-tongue squamous cell carcinoma (TSCC and BOTSCC, respectively) is increasing epidemically, but they have better prognosis than equivalent HPV-negative (HPV−) cancers, with
Externí odkaz:
https://doaj.org/article/4a4e2f357f734903a724f1a5287c278e
Autor:
Koon-Chu Yaiw, Abdul-Aleem Mohammad, Chato Taher, Huanhuan Leah Cui, Helena Costa, Ourania N. Kostopoulou, Masany Jung, Alice Assinger, Vanessa Wilhelmi, Jiangning Yang, Klas Strååt, Afsar Rahbar, John Pernow, Cecilia Söderberg-Nauclér
Publikováno v:
Microorganisms, Vol 9, Iss 6, p 1137 (2021)
Human cytomegalovirus (HCMV) is an opportunistic pathogen that has been implicated in the pathogenesis of atherosclerosis. Endothelin-1 (ET-1), a potent vasoconstrictive peptide, is overexpressed and strongly associated with many vasculopathies. The
Externí odkaz:
https://doaj.org/article/450b486a1a8a40138f75bfeea0536c1c
Autor:
Linnéa Ödborn Jönsson, Maryam Sahi, Ximena Lopez-Lorenzo, Faye Leilah Keller, Ourania N. Kostopoulou, Nikolas Herold, Lars Ährlund-Richter, Shahrzad Shirazi Fard
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3664 (2021)
Most chemotherapeutics target DNA integrity and thereby trigger tumour cell death through activation of DNA damage responses that are tightly coupled to the cell cycle. Disturbances in cell cycle regulation can therefore lead to treatment resistance.
Externí odkaz:
https://doaj.org/article/f31fbd8ae8dd46f3b8f01f63e75c0b32
Autor:
Afsar Rahbar, Amira AlKharusi, Helena Costa, Mattia Russel Pantalone, Ourania N. Kostopoulou, Huanhuan L. Cui, Joseph Carlsson, Angelique Flöter Rådestad, Cecilia Söderberg-Naucler, Gunnar Norstedt
Publikováno v:
Biology, Vol 9, Iss 3, p 44 (2020)
One of the potential biomarkers for ovarian cancer patients is high serum level of prolactin (PRL), which is a growth factor that may promote tumor cell growth. The prolactin receptor (PRLR) and human cytomegalovirus (HCMV) proteins are frequently de
Externí odkaz:
https://doaj.org/article/10065153a7274f8f9ee5daa8cb8f1330