Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Oumeya, Adjali"'
Autor:
Magalie Penaud-Budloo, Emilie Lecomte, Quentin Lecomte, Simon Pacouret, Frédéric Broucque, Aurélien Guy-Duché, Jean-Baptiste Dupont, Laurence Jeanson-Leh, Cécile Robin, Véronique Blouin, Eduard Ayuso, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101305- (2024)
With more than 130 clinical trials and 8 approved gene therapy products, adeno-associated virus (AAV) stands as one of the most popular vehicles to deliver therapeutic DNA in vivo. One critical quality attribute analyzed in AAV batches is the presenc
Externí odkaz:
https://doaj.org/article/042640a504cc42909af1d623d410fa67
Autor:
Anais Defois, Nina Bon, Mathieu Mével, David Deniaud, Yves Maugars, Jérôme Guicheux, Oumeya Adjali, Claire Vinatier
Publikováno v:
Journal of Cartilage & Joint Preservation, Vol 4, Iss 2, Pp 100186- (2024)
Introduction: Osteoarthritis (OA), the most common form of joint disease, affects more than 500 million people worldwide. This painful and debilitating disease imposes a huge socioeconomic cost worldwide. Despite years of promising research, no etiol
Externí odkaz:
https://doaj.org/article/88140a72be4d4f7b9fc8ae02b09f9ce1
Autor:
Caroline Le Guiner, Xiao Xiao, Thibaut Larcher, Aude Lafoux, Corinne Huchet, Gilles Toumaniantz, Oumeya Adjali, Ignacio Anegon, Séverine Remy, Josh Grieger, Juan Li, Vahid Farrokhi, Hendrik Neubert, Jane Owens, Maritza McIntyre, Philippe Moullier, R. Jude Samulski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 30-47 (2023)
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by loss-of-function mutations in the dystrophin gene and is characterized by muscle wasting and early mortality. Adeno-associated virus-mediated gene therapy is being investigated as a t
Externí odkaz:
https://doaj.org/article/7a89e1515ecf4452944c4318d3851f25
Autor:
Mathieu Mével, Virginie Pichard, Mohammed Bouzelha, Dimitri Alvarez-Dorta, Pierre-Alban Lalys, Nathalie Provost, Marine Allais, Alexandra Mendes, Elodie Landagaray, Jean-Baptiste Ducloyer, Estelle Toublanc, Anne Galy, Nicole Brument, Gaëlle M. Lefevre, Sébastien G. Gouin, Carolina Isiegas, Guylène Le Meur, Thérèse Cronin, Caroline Le Guiner, Michel Weber, Philippe Moullier, Eduard Ayuso, David Deniaud, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101187- (2024)
Inherited retinal diseases are a leading and untreatable cause of blindness and are therefore candidate diseases for gene therapy. Recombinant vectors derived from adeno-associated virus (rAAV) are currently the most promising vehicles for in vivo th
Externí odkaz:
https://doaj.org/article/1edecadd12924319b147b4cab1a426f8
Autor:
Jean-Baptiste Ducloyer, Virginie Pichard, Mathieu Mevel, Anne Galy, Gaelle M. Lefevre, Nicole Brument, Dimitri Alvarez-Dorta, David Deniaud, Alexandra Mendes-Madeira, Lyse Libeau, Caroline Le Guiner, Therese Cronin, Oumeya Adjali, Michel Weber, Guylène Le Meur
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 387-393 (2023)
The subretinal injection protocol for the only approved retinal gene therapy (voretigene neparvovec-rzyl) includes air tamponade at the end of the procedure, but its effects on the subretinal bleb have not been described. In the present study, we eva
Externí odkaz:
https://doaj.org/article/dc74dd4179c14ad388bcdc95456b14ed
Autor:
Anna Creisméas, Claire Gazaille, Audrey Bourdon, Marc-Antoine Lallemand, Virginie François, Marine Allais, Mireille Ledevin, Thibaut Larcher, Gilles Toumaniantz, Aude Lafoux, Corinne Huchet, Ignacio Anegon, Oumeya Adjali, Caroline Le Guiner, Bodvaël Fraysse
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused by mutations in the gene encoding dystrophin that leads to a severe and ultimately life limiting muscle-wasting condition. Recombinant adeno-associated vect
Externí odkaz:
https://doaj.org/article/df4837365a234a57b360f01bc60d2a4d
Autor:
Gwladys Gernoux, Mickaël Guilbaud, Marie Devaux, Malo Journou, Virginie Pichard, Nicolas Jaulin, Adrien Léger, Johanne Le Duff, Jack-Yves Deschamps, Caroline Le Guiner, Philippe Moullier, Yan Cherel, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 660-674 (2021)
Adeno-associated virus (AAV) vectors are considered efficient vectors for gene transfer, as illustrated by recent successful clinical trials targeting retinal or neurodegenerative disorders. However, limitations as host immune responses to AAV capsid
Externí odkaz:
https://doaj.org/article/38d74ee6093e4b7fa86f324ccc982a8e
Autor:
Denis Horgan, Andres Metspalu, Marie-Christine Ouillade, Dimitrios Athanasiou, John Pasi, Oumeya Adjali, Patrick Harrison, Cedric Hermans, Giovanni Codacci-Pisanelli, Jasmina Koeva, Thomas Szucs, Viorica Cursaru, Ivica Belina, Chiara Bernini, Suijie Zhuang, Stephen McMahon, Draga Toncheva, Thomas Thum
Publikováno v:
Biomedicine Hub, Vol 5, Iss 3, Pp 1-23 (2020)
Recent advances in biomedicine are opening the door to new approaches, and treatment and prevention are being transformed by novel medicines based on genetic engineering, innovative cell-based therapies and tissue-engineered products, and combination
Externí odkaz:
https://doaj.org/article/03c4b1c6d73e4f6bbb7d99038dd42ff2
Autor:
Pauline F. Schmit, Simon Pacouret, Eric Zinn, Elizabeth Telford, Fotini Nicolaou, Frédéric Broucque, Eva Andres-Mateos, Ru Xiao, Magalie Penaud-Budloo, Mohammed Bouzelha, Nicolas Jaulin, Oumeya Adjali, Eduard Ayuso, Luk H. Vandenberghe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 107-121 (2020)
Generation and screening of libraries of adeno-associated virus (AAV) variants have emerged as a powerful method for identifying novel capsids for gene therapy applications. For the majority of libraries, vast population diversity requires multiplexe
Externí odkaz:
https://doaj.org/article/01e94c81cf474557ad14df40eac9da49
Autor:
Karim Bey, Johan Deniaud, Laurence Dubreil, Béatrice Joussemet, Joseph Cristini, Carine Ciron, Juliette Hordeaux, Morwenn Le Boulc’h, Kevin Marche, Maud Maquigneau, Michaël Guilbaud, Rosalie Moreau, Thibaut Larcher, Jack-Yves Deschamps, Marion Fusellier, Véronique Blouin, Caroline Sevin, Nathalie Cartier, Oumeya Adjali, Patrick Aubourg, Philippe Moullier, Marie-Anne Colle
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 771-784 (2020)
The identification of the most efficient method for whole central nervous system targeting that is translatable to humans and the safest route of adeno-associated virus (AAV) administration is a major concern for future applications in clinics. Addit
Externí odkaz:
https://doaj.org/article/a0aedb1aca064422b991e72f09f1cc8d