Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Oula C. Mansour"'
Autor:
Oula C. Mansour, Abraham Nudelman, Ada Rephaeli, Don R. Phillips, Suzanne M. Cutts, Benny J. Evison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:773-784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb5e36acd66c676857317f6b24b4a17
https://doi.org/10.1007/s00280-022-04435-1
https://doi.org/10.1007/s00280-022-04435-1
Autor:
Oula C, Mansour, Abraham, Nudelman, Ada, Rephaeli, Don R, Phillips, Suzanne M, Cutts, Benny J, Evison
Publikováno v:
Cancer chemotherapy and pharmacology. 89(6)
Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin's lymphoma. The drug is firmly established as a poison of the nuclear enzyme topoisomerase II, however, pixantrone can also generate covalent drug-DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::229458ca9d75d78a77adf2e3d6bb47df
https://pubmed.ncbi.nlm.nih.gov/35460360
https://pubmed.ncbi.nlm.nih.gov/35460360
Publikováno v:
American Journal of Plant Sciences. :148-155
Nascent pectin and glucuronoxylan were prepared from membrane-bound enzymes obtained from pea epicotyls. They had previously been shown to exhibit a protein- and pH-dependent pattern of binding to cell wall ghosts and to xy-loglucan extracted from ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e72e8fe966754ec6f003d9840ee7ab40
https://doi.org/10.4236/ajps.2011.22016
https://doi.org/10.4236/ajps.2011.22016
Autor:
Oula C. Mansour, Don R. Phillips, J. Grant Collins, Benny J. Evison, Damian P. Buck, Brad E. Sleebs, Ada Rephaeli, Suzanne M. Cutts, Abraham Nudelman, Keith G. Watson, Rebecca A. Bilardi
Publikováno v:
Journal of Medicinal Chemistry. 53:6851-6866
Mitoxantrone is an anticancer agent that acts as a topoisomerase II poison, however, it can also be activated by formaldehyde to form DNA adducts. Pixantrone, a 2-aza-anthracenedione with terminal primary amino groups in its side chains, forms formal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4aaa45fb203cac3502a75b72c39b0b8
https://doi.org/10.1021/jm901894c
https://doi.org/10.1021/jm901894c
Publikováno v:
Nucleic Acids Research
Mitoxantrone is an anti-cancer agent used in the treatment of breast and prostate cancers. It is classified as a topoisomerase II poison, however can also be activated by formaldehyde to generate drug-DNA adducts. Despite identification of this novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c7f4f43e7fda6251b01c39a0082d40
http://europepmc.org/articles/PMC1920253
http://europepmc.org/articles/PMC1920253
Autor:
Nancy Zu, Laurie J. Minze, Guohui Wang, Oula C. Mansour, Jiawei Zhang, Renduo Song, Amanda M. Weiskoff, Li Bai, Zheng Zheng Shi, Prince Jeyabal, Zihua Zeng, William C. Merrick, Shu Zheng, Luchang Wang, Huarong Chen, Valentina Rubio, Chunying Yang, Zonghui Ding
Publikováno v:
Scientific Reports
Translation is a fundamental cellular process and its dysregulation can contribute to human diseases such as cancer. During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary complex (TC) with GTP and the initiator methi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073047658a728e5e4c695404998eee57
Autor:
Abraham Nudelman, Ada Rephaeli, Brad E. Sleebs, Oula C. Mansour, Benny J. Evison, Suzanne M. Cutts, Keith G. Watson, Don R. Phillips
Publikováno v:
Cancer Research. 70:3507-3507
Pixantrone is a novel aza-anthracenedione originally developed to improve the therapeutic profile of mitoxantrone, a DNA-interactive agent currently used in the clinical management of a range of haematological malignancies and solid tumours. Like mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::578d8ce097d3bffbbc514a166edd0025
https://doi.org/10.1158/1538-7445.am10-3507
https://doi.org/10.1158/1538-7445.am10-3507