IL-23 stabilizes an effector T reg cell program in the tumor microenvironment.

Autor: Wertheimer T; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Zwicky P; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Rindlisbacher L; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Sparano C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Vermeer M; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., de Melo BMS; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Department of Pharmacology, Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Haftmann C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Rückert T; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany., Sethi A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Schärli S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Huber A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Ingelfinger F; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Xu C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Kim D; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Häne P; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Fonseca da Silva A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Muschaweckh A; Institute for Experimental Neuroimmunology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Nunez N; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Krishnarajah S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Köhler N; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Zeiser R; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Oukka M; Department of Immunology, University of Washington, Seattle, WA, USA., Korn T; Institute for Experimental Neuroimmunology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Tugues S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. tugues@immunology.uzh.ch., Becher B; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. becher@immunology.uzh.ch.

Publikováno v: Nature immunology [Nat Immunol] 2024 Mar; Vol. 25 (3), pp. 512-524. Date of Electronic Publication: 2024 Feb 14.

Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome.

Autor: Largent AD; Seattle Children's Research Institute, Seattle, WA 98101, USA., Lambert K; Benaroya Research Institute, Seattle, WA 98101, USA., Chiang K; Seattle Children's Research Institute, Seattle, WA 98101, USA., Shumlak N; Seattle Children's Research Institute, Seattle, WA 98101, USA., Liggitt D; Department of Comparative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Oukka M; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA., Torgerson TR; Allen Institute for Immunology, Seattle, WA 98109, USA., Buckner JH; Benaroya Research Institute, Seattle, WA 98101, USA., Allenspach EJ; Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA., Rawlings DJ; Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA., Jackson SW; Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jul 05; Vol. 15 (703), pp. eade7028. Date of Electronic Publication: 2023 Jul 05.

Angiotensin II-induced a steeper blood pressure elevation in IL-23 receptor-deficient mice: Role of interferon-γ-producing T cells.

Autor: Shokoples BG; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Comeau K; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Higaki A; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Ferreira NS; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Caillon A; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Berillo O; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Oukka M; Department of Immunology, University of Washington, Seattle, WA, USA., Paradis P; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada., Schiffrin EL; Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada. ernesto.schiffrin@mcgill.ca.; Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC, Canada. ernesto.schiffrin@mcgill.ca.

Publikováno v: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2023 Jan; Vol. 46 (1), pp. 40-49. Date of Electronic Publication: 2022 Oct 15.

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