Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

Autor: Song, C, Burgess, S, Eicher, JD, O'Donnell, CJ, Johnson, AD, Huang, J, Sabater-Lleal, M, Asselbergs, FW, Tregouet, D, Shin, SY, Ding, J, Baumert, J, Oudot-Mellakh, T, Folkersen, L, Smith, NL, Williams, SM, Ikram, MA, Kleber, ME, Becker, DM, Truong, V, Mychaleckyj, JC, Tang, W, Yang, Q, Sennblad, B, Moore, JH, Williams, FMK, Dehghan, A, Silbernagel, G, Schrijvers, EMC, Smith, S, Karakas, M, Tofler, GH, Silveira, A, Navis, GJ, Lohman, K, Chen, MH, Peters, A, Goel, A, Hopewell, JC, Chambers, JC, Saleheen, D, Lundmark, P, Psaty, BM, Strawbridge, RJ, Boehm, BO, Carter, AM, Meisinger, C, Peden, JF, Bis, JC, McKnight, B, Öhrvik, J, Taylor, K, Franzosi, MG, Seedorf, U, Collins, R, Franco-Cereceda, A, Syvänen, AC, Goodall, AH, Yanek, LR, Cushman, M, Müller-Nurasyid, M, Folsom, AR, Basu, S, Matijevic, N, Van Gilst, WH, Kooner, JS, Danesh, J, Clarke, R, Meigs, JB, Kathiresan, S, Reilly, MP, Klopp, N, Harris, TB, Winkelmann, BR, Grant, PJ, Hillege, HL, Watkins, H, Spector, TD, Becker, LC, Tracy, RP, März, W, Uitterlinden, AG, Eriksson, P, Cambien, F, Morange, PE, Koenig, W, Soranzo, N, Van der Harst, P, Liu, Y, Hamsten, A, Ehret, GB, Munroe, PB, Rice, KM, Bochud, M, Chasman, DI, Smith, AV

Publikováno v: Journal of the American Heart Association, 6(6):e004918. Wiley-Blackwell Publishing Ltd
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, vol 6, iss 6
Journal of the American Heart Association, 6(6). Wiley-Blackwell

Background Plasminogen activator inhibitor type 1 ( PAI ‐1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI ‐1 levels are associated with increased risk of coronary heart disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb33728a45e61e96cf5736dad02211
https://pure.eur.nl/en/publications/a644d69d-078f-4e47-abaa-b2c097ffb31e

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Autor: Sabater-Lleal, M., Huang, J., Chasman, D., Naitza, S., Dehghan, A., Johnson, A.D., Teumer, A., Reiner, A.P., Folkersen, L., Basu, S., Rudnicka, A.R., Trompet, S., Malarstig, A., Baumert, J., Bis, J.C., Guo, X.Q., Hottenga, J.J., Shin, S.Y., Lopez, L.M., Lahti, J., Tanaka, T., Yanek, L.R., Oudot-Mellakh, T., Wilson, J.F., Navarro, P., Huffman, J.E., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, A.F., Kolcic, I., Polasek, O., Wild, S.H., Campbell, H., Curb, J.D., Wallace, R., Liu, S.M., Eaton, C.B., Becker, D.M., Becker, L.C., Bandinelli, S., Raikkonen, K., Widen, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G., Harris, S.E., Liewald, D.C., Starr, J.M., Williams, F.M.K., Grant, P.J., Spector, T.D., Strawbridge, R.J., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, A.G., Franco, O.H., Hofman, A., Dongen, J. van, Willemsen, G., Boomsma, D.I., Yao, J., Jenny, N.S., Haritunians, T., McKnight, B., Lumley, T., Taylor, K.D., Rotter, J.I., Psaty, B.M., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Volzke, H., Kocher, T., Goel, A., Franzosi, M.G., Seedorf, U., Clarke, R., Steri, M., Tarasov, K.V., Sanna, S., Schlessinger, D., Stott, D.J., Sattar, N., Buckley, B.M., Rumley, A., Lowe, G.D., McArdle, W.L., Chen, M.H., Tofler, G.H., Song, J., Boerwinkle, E., Folsom, A.R., Rose, L.M., Franco-Cereceda, A., Teichert, M., Ikram, M.A., Mosley, T.H., Bevan, S., Dichgans, M., Rothwell, P.M., Sudlow, C.L.M., Hopewell, J.C., Chambers, J.C., Saleheen, D., Kooner, J.S., Danesh, J., Nelson, C.P., Erdmann, J., Reilly, M.P., Kathiresan, S., Schunkert, H., Morange, P.E., Ferrucci, L., Eriksson, J.G., Jacobs, D., Deary, I.J., Soranzo, N., Witteman, J.C.M., Geus, E.J.C. de, Tracy, R.P., Hayward, C., Koenig, W., Cucca, F., Jukema, J.W., Eriksson, P., Seshadri, S., Markus, H.S., Watkins, H., Samani, N.J., Wallaschofski, H., Smith, N.L., Tregouet, D., Ridker, P.M., Tang, W.H., Strachan, D.P., Hamsten, A., O'Donnell, C.J., VTE Consortium, STROKE Consortium, WTCCC2, CD4 Consortium, CARDIoGRAM Consortium

Publikováno v: Circulation, 128, 1310-24
Circulation, 128(12), 1310-1324. Lippincott Williams & Wilkins
Circulation, 128(12), 1310-1324. American Heart Association
Circulation
Circulation, 128(12), 1310-1324
Sabater-Lleal, M, Huang, J, Chasman, D I, Naitza, S, Dehghan, A, Johnson, A D, Teumer, A, Reiner, A P, Folkersen, L, Basu, S, Rudnicka, A R, Trompet, S, Mälarstig, A, Baumert, J, Bis, J C, Guo, X, Hottenga, J J, Shin, S Y, Lopez, L M, Lahti, J, Tanaka, T, Yanek, L R, Oudot-Mellakh, T, Wilson, J F, Navarro, P, Huffman, J E, Zemunik, T, Redline, S, Mehra, R, Pulanic, D, Rudan, I, Wright, A F, Kolcic, I, Polasek, O, Wild, S H, Campbell, H, Curb, J D, Wallace, R, Liu, S, Eaton, C B, Becker, D M, Becker, L C, Bandinelli, S, Räikkönen, K, Widén, E, Palotie, A, Fornage, M, Green, D, Gross, M, Davies, G E, Harris, S E, Liewald, D C, Starr, J M, Williams, F M, Grant, P J, Spector, T D, Strawbridge, R J, Silveira, A, Sennblad, B, Rivadeneira, F, Uitterlinden, A G, Franco, O H, Hofman, A, van Dongen, J, Willemsen, G, Boomsma, D I, Yao, J, Swords Jenny, N, Haritunians, T, McKnight, B, Lumley, T, Taylor, K D, Rotter, J I, Psaty, B M, Peters, A, Gieger, C, Illig, T, Grotevendt, A, Homuth, G, Völzke, H, Kocher, T, Goel, A, Franzosi, M G, Seedorf, U, Clarke, R, Steri, M, Tarasov, K V, Sanna, S, Schlessinger, D, Stott, D J, Sattar, N, Buckley, B M, Rumley, A, Lowe, G D, McArdle, W L, Chen, M H, Tofler, G H, Song, J, Boerwinkle, E, Folsom, A R, Rose, L M, Franco-Cereceda, A, Teichert, M, Ikram, M A, Mosley, T H, Bevan, S, Dichgans, M, Rothwell, P M, Sudlow, C L, Hopewell, J C, Chambers, J C, Saleheen, D, Kooner, J S, Danesh, J, Nelson, C P, Erdmann, J, Reilly, M P, Kathiresan, S, Schunkert, H, Morange, P E, Ferrucci, L, Eriksson, J G, Jacobs, D, Deary, I J, Soranzo, N, Witteman, J C, de Geus, E J C, Tracy, R P, Hayward, C, Koenig, W, Cucca, F, Jukema, J W, Eriksson, P, Seshadri, S, Markus, H S, Watkins, H, Samani, N J, Wallaschofski, H, Smith, N L, Tregouet, D A, Ridker, P M, Tang, W, Strachan, D P, Hamsten, A & O'Donnell, C J 2013, ' Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease ', Circulation, vol. 128, no. 12, pp. 1310-1324 . https://doi.org/10.1161/CIRCULATIONAHA.113.002251
Circulation; Vol 128
Circulation, 128, 12, pp. 1310-24
Sabater-Lleal, M, Huang, J, Chasman, D, Naitza, S, Dehghan, A, Johnson, A D, Teumer, A, Reiner, A P, Folkersen, L, Basu, S, Rudnicka, A R, Trompet, S, Malarstig, A, Baumert, J, Bis, J C, Guo, X, Hottenga, J J, Shin, S-Y, Lopez, L M, Lahti, J, Tanaka, T, Yanek, L R, Oudot-Mellakh, T, Wilson, J F, Navarro, P, Huffman, J E, Zemunik, T, Redline, S, Mehra, R, Pulanic, D, Rudan, I, Wright, A F, Kolcic, I, Polasek, O, Wild, S H, Campbell, H, Curb, J D, Wallace, R, Liu, S, Eaton, C B, Becker, D M, Becker, L C, Bandinelli, S, Davies, G & Harris, S E & Liewald, D C & Starr, J M & Grant, P J & Deary, I J & Hayward, C 2013, ' Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease ', Circulation, vol. 128, no. 12, pp. 1310-1324 . https://doi.org/10.1161/CIRCULATIONAHA.113.002251

Background— Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc930b29de59ed1bb80242b123c43150
http://hdl.handle.net/2066/129364

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