Výsledky vyhledávání - "Ouda Aboumanify"

Akademický článek

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer

Autor: Janina Hesse, Julien Martinelli, Ouda Aboumanify, Annabelle Ballesta, Angela Relógio

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5170-5183 (2021)

Scheduling anticancer drug administration over 24 h may critically impact treatment success in a patient-specific manner. Here, we address personalization of treatment timing using a novel mathematical model of irinotecan cellular pharmacokinetics an

Externí odkaz: https://doaj.org/article/d99649a237284b679a0573aca4da6df1

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Akademický článek

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day

Autor: Alireza Basti, Müge Yalçin, David Herms, Janina Hesse, Ouda Aboumanify, Yin Li, Zita Aretz, Josefin Garmshausen, Rukeia El-Athman, Maria Hastermann, Dieter Blottner, Angela Relógio

Publikováno v: BMJ Open Sport & Exercise Medicine, Vol 7, Iss 1 (2021)

Objectives In this study, we investigated daily fluctuations in molecular (gene expression) and physiological (biomechanical muscle properties) features in human peripheral cells and their correlation with exercise performance.Methods 21 healthy part

Externí odkaz: https://doaj.org/article/8a41bc736916486b8ffc89002d93fcd0

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A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer

Autor: Ouda Aboumanify, Angela Relógio, Julien Martinelli, Janina Hesse, Annabelle Ballesta

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5170-5183 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, 2021, 19, pp.5170-5183. ⟨10.1016/j.csbj.2021.08.051⟩

Graphical abstract
Scheduling anticancer drug administration over 24 h may critically impact treatment success in a patient-specific manner. Here, we address personalization of treatment timing using a novel mathematical model of irinotecan cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f8d48230f132ae8ecd4b66ea596f4
http://www.sciencedirect.com/science/article/pii/S2001037021003822

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