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Autor:
Ouaray, Zahra
The p53 tumour suppressor protein functions as a transcription factor to prevent cancer by inducing cell cycle arrest, DNA repair and apoptosis. 50% of cancers are associated with a mutation on this protein; indeed mutated p53 either loses its capaci
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667505
Publikováno v:
In Journal of Biological Chemistry 11 December 2020 295(50):17046-17059
Akademický článek
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Most p53 mutations associated with cancer are located in its DNA binding domain (DBD). Many structures (X-ray and NMR) of this domain are available in the protein data bank (PDB) and a vast conformational heterogeneity characterizes the various free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______348::c0eb7e58dfd53b8e5a6d124aa05b3cae
https://eprints.soton.ac.uk/402297/
https://eprints.soton.ac.uk/402297/
Autor:
Ouaray Z; School of Chemistry, University of Southampton, Southampton, SO17 1BJ, United Kingdom.; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore., ElSawy KM; York Centre for Complex Systems Analysis (YCCSA), University of York, York, YO10 5GE, United Kingdom.; Department of Chemistry, College of Science, Qassim University, Buraydah, 52571, Saudi Arabia., Lane DP; p53 Laboratory, Agency for Science, Technology and Research, Singapore, 138648, Singapore., Essex JW; School of Chemistry, University of Southampton, Southampton, SO17 1BJ, United Kingdom. J.W.Essex@soton.ac.uk., Verma C; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore.; School of Biological Sciences, Nanyang Technological University, 637551, Singapore.; Department of Biological Sciences, National University of Singapore, 117543, Singapore.
Publikováno v:
Proteins [Proteins] 2016 Oct; Vol. 84 (10), pp. 1443-61. Date of Electronic Publication: 2016 Jul 26.