Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Otto W. Woltersdorf"'
Autor:
M. Katharine Holloway, Jenny M. Wai, Thomas A. Halgren, Paula M. D. Fitzgerald, Joseph P. Vacca, Bruce D. Dorsey, Rhonda B. Levin, Wayne J. Thompson, L. Jenny Chen, S. Jane deSolms, Neil Gaffin, Arun K. Ghosh, Elizabeth A. Giuliani, Samuel L. Graham, James P. Guare, Randall W. Hungate, Terry A. Lyle, William M. Sanders, Thomas J. Tucker, Mark Wiggins, Catherine M. Wiscount, Otto W. Woltersdorf, Steven D. Young, Paul L. Darke, Joan A. Zugay
Publikováno v:
Journal of Medicinal Chemistry. 39:2280-2280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b746b20a4f7359688518a60ef3d3ee6
https://doi.org/10.1021/jm960144h
https://doi.org/10.1021/jm960144h
Publikováno v:
Journal of Medicinal Chemistry. 21:437-443
The introduction of an aryl group at the 2 position of the uricosuric diuretics, (1-oxo-2-alkyl-5-indanyloxy)acetic acids, provided compounds with markedly increased potency over their monosubstituted precursors. These compounds were synthesized eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7380ed9009f06aecf3f5ac1460372db4
https://doi.org/10.1021/jm00203a006
https://doi.org/10.1021/jm00203a006
Autor:
Otto W. Woltersdorf, L. S. Watson, Everett M. Schultz, Gerald E. Stokker, J. D. Schneeberg, Cragoe Edward J, G. M. Fanelli
Publikováno v:
Journal of Medicinal Chemistry. 18:225-228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15bebc1106a2c72372d263a184f7f4c
https://doi.org/10.1021/jm00236a031
https://doi.org/10.1021/jm00236a031
Autor:
P. Gautheron, Otto W. Woltersdorf, Harvey Schwam, S J deSolms, Jacob M. Hoffman, Samuel L. Graham, Fishman Dr, Larson Rd, John B. Bicking, Brown Sl
Publikováno v:
Journal of Medicinal Chemistry. 32:2486-2492
A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined. In vitro studies showed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89350751c071a54f0545af7db5f5113a
https://doi.org/10.1021/jm00131a011
https://doi.org/10.1021/jm00131a011
Publikováno v:
Journal of Medicinal Chemistry. 27:840-845
Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones. In general, both pharmacological parameters (uricosuria and diuresis) were sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069b37b56078e8a9db37e591b6a0c0a0
https://doi.org/10.1021/jm00373a005
https://doi.org/10.1021/jm00373a005
Autor:
C. Stanley Rooney, S. Jane De Solms, C. M. Robb, Edward J. Cragoe, Otto W. Woltersdorf, Haydn W. R. Williams, John B. Bicking
Publikováno v:
The Journal of Organic Chemistry. 44:4060-4063
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e73f1e6e5df92f5d4eb2e4cececd9865
https://doi.org/10.1021/jo01337a008
https://doi.org/10.1021/jo01337a008
Autor:
Otto W. Woltersdorf
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 17:635-639
The enantiomers of MK-196, (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)-acetic acid, and the 2-(4-hydroxyphenyl) derivative, the major metabolite of MK-196, were resolved by classical methods using α-methylbenzylamine salts, and converted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f36ba5f3763b6c46c2f33e31d7842d7c
https://doi.org/10.1002/jlcr.2580170505
https://doi.org/10.1002/jlcr.2580170505
Autor:
Otto W. Woltersdorf, Sara F. Kwong, John B. Bicking, C. M. Robb, James H. Jones, James W. Mason, Edward J. Cragoe
Publikováno v:
Journal of Medicinal Chemistry. 8:638-642
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02dd43b570374ae6992656e000e40003
https://doi.org/10.1021/jm00329a017
https://doi.org/10.1021/jm00329a017
Publikováno v:
Journal of Medicinal and Pharmaceutical Chemistry. 5:896-912
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98d8206fd0f68388669a82018575379
https://doi.org/10.1021/jm01240a002
https://doi.org/10.1021/jm01240a002
Publikováno v:
Journal of Medicinal Chemistry. 12:280-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434f85a1898b0588b89333cf2e794c0f
https://doi.org/10.1021/jm00302a018
https://doi.org/10.1021/jm00302a018