Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Otto Savolainen"'
Autor:
Álvaro González-Domínguez, Otto Savolainen, Jesús Domínguez-Riscart, Rikard Landberg, Alfonso Lechuga-Sancho, Raúl González-Domínguez
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Although insulin resistance (IR) is among the most frequent and pathogenically relevant complications accompanying childhood obesity, its role in modulating and exacerbating obesity pathophysiology has not yet been completely clar
Externí odkaz:
https://doaj.org/article/4d8840ecfb0f44599a93513dea5c9ccf
Autor:
Álvaro González-Domínguez, Jesús Domínguez-Riscart, Otto Savolainen, Alfonso Lechuga-Sancho, Rikard Landberg, Raúl González-Domínguez
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background Insulin resistance is a frequent precursor of typical obesity and metabolic syndrome complications. However, accurate diagnosis remains elusive because of its pathophysiological complexity and heterogeneity. Herein, we have explor
Externí odkaz:
https://doaj.org/article/d1c692f6b710470c9027ba6e5fb5e298
Autor:
Maria K. Magnusson, Anna Bas Forsberg, Alexandra Verveda, Maria Sapnara, Julie Lorent, Otto Savolainen, Yvonne Wettergren, Hans Strid, Magnus Simrén, Lena Öhman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9886 (2024)
Microbiota and luminal components may affect epithelial integrity and thus participate in the pathophysiology of colon cancer (CC) and inflammatory bowel disease (IBD). Therefore, we aimed to determine the effects of fecal luminal factors derived fro
Externí odkaz:
https://doaj.org/article/be778374bd1142b0a97e16ddcd6b73e9
Autor:
Frida Gorreja, Mia Bendix, Stephen T. A. Rush, Lujain Maasfeh, Otto Savolainen, Anders Dige, Jorgen Agnholt, Lena Öhman, Maria K. Magnusson
Publikováno v:
Cells, Vol 13, Iss 1, p 60 (2023)
Intestinal macrophages and fibroblasts act as microenvironmental sentinels mediating inflammation and disease progression in Crohn’s disease (CD). We aimed to establish the effects of fecal supernatants (FSs) from patients with CD on macrophage and
Externí odkaz:
https://doaj.org/article/e621b314c63240b4b7241ae70d60f38b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Isoflavonoids are a class of industrially important plant natural products, but their low abundance and structural complexity limits their availability. Here, the authors engineer Saccharomyces cerevisiae metabolism to become a platform for efficient
Externí odkaz:
https://doaj.org/article/d6bb06999aec498f8d54a214590bbba7
Autor:
Lujain Maasfeh, Anetta Härtlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Öhman, Maria K. Magnusson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1415-1432 (2021)
Background & Aims: Intestinal macrophages adopt a hyporesponsive phenotype through education by local signals. Lack of proper macrophage maturation in patients with ulcerative colitis (UC) in remission may initiate gut inflammation. The aim, therefor
Externí odkaz:
https://doaj.org/article/cb556344adb14d9b9261e46d9bcea45c
Autor:
Luiza Moraes Holst, Cristina Iribarren, Maria Sapnara, Otto Savolainen, Hans Törnblom, Yvonne Wettergren, Hans Strid, Magnus Simrén, Maria K. Magnusson, Lena Öhman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15505 (2022)
Previous in vitro studies have shown that the intestinal luminal content, including metabolites, possibly regulates epithelial layer responses to harmful stimuli and promotes disease. Therefore, we aimed to test the hypothesis that fecal supernatants
Externí odkaz:
https://doaj.org/article/e21665a31a9e45f2bdb30a0058a228c1
Autor:
Bani Ahluwalia, Maria K. Magnusson, Fredrik Larsson, Otto Savolainen, Alastair B. Ross, Lena Öhman
Publikováno v:
Molecules, Vol 27, Iss 19, p 6643 (2022)
Aloe barbadensis Mill. (Aloe) is used for diverse therapeutic properties including immunomodulation. However, owing to the compositionally complex nature of Aloe, bioactive component(s) responsible for its beneficial properties, though thought to be
Externí odkaz:
https://doaj.org/article/31c20c1fe03c4c93a7a2660c4543b51b
Autor:
Agnes Dahlstrand Rudin, Arsham Khamzeh, Vignesh Venkatakrishnan, Tishana Persson, Michael Gabl, Otto Savolainen, Huamei Forsman, Claes Dahlgren, Karin Christenson, Johan Bylund
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Neutrophil migration from blood to tissue-residing microbes is governed by a series of chemoattractant gradients of both endogenous and microbial origin. Periodontal disease is characterized by neutrophil accumulation in the gingival pocket, recruite
Externí odkaz:
https://doaj.org/article/3fab8d504a6d4e3d8d51af1898f2fe37
Autor:
Alastair B Ross, Malin Barman, Olle Hartvigsson, Anna-Carin Lundell, Otto Savolainen, Bill Hesselmar, Agnes E Wold, Ann-Sofie Sandberg
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0242978 (2021)
Allergy is one of the most common diseases among young children yet all factors that affect development of allergy remain unclear. In a small cohort of 65 children living in the same rural area of south-west Sweden, we have previously found that mate
Externí odkaz:
https://doaj.org/article/1ed68c0316c04ce58cdeb917f026fe77