Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Otto Lindemann"'
Autor:
Peter Dieterich, Otto Lindemann, Mats Leif Moskopp, Sebastien Tauzin, Anna Huttenlocher, Rainer Klages, Aleksei Chechkin, Albrecht Schwab
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010089 (2022)
The motility of neutrophils and their ability to sense and to react to chemoattractants in their environment are of central importance for the innate immunity. Neutrophils are guided towards sites of inflammation following the activation of G-protein
Externí odkaz:
https://doaj.org/article/d7ddae628dd54a7493c3efcc3bf6511b
Autor:
Alexander Zarbock, Jan Rossaint, Mike Wälte, Verena Hofschröer, Otto Lindemann, Benedikt Fels, Sandra Schimmelpfennig, Albrecht Schwab, Hans Oberleithner, Karolina Najder
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract Here we report a novel role for TRPC6, a member of the transient receptor potential (TRPC) channel family, in the CXCL1-dependent recruitment of murine neutrophil granulocytes. Representing a central element of the innate immune system, neut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da225f91b88271c02810fe670f3f402
https://doi.org/10.1007/s00109-020-01872-4
https://doi.org/10.1007/s00109-020-01872-4
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:1017-1033
Neutrophil granulocytes are exposed to widely varying microenvironmental conditions when pursuing their physiological or pathophysiological functions such as fighting invading bacteria or infiltrating cancer tissue. Examples for harsh environmental c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf3ee611ec60b3a4b631cba42faed14
https://doi.org/10.1007/s00424-018-2146-8
https://doi.org/10.1007/s00424-018-2146-8
Autor:
Sven Christian, Albrecht Schwab, Sven G. Meuth, Otto Lindemann, Sandra Schimmelpfennig, Ilya Kovalenko, Natalia Prevarskaya, Jana Welzig, Kateryna Kondratska, Nikolaj Nielsen, Sarah Sargin, Benedikt Hild, Tobias Ruck
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 469:1567-1577
Pancreatic cancer is characterized by a massive fibrosis (desmoplasia), which is primarily caused by activated pancreatic stellate cells (PSCs). This leads to a hypoxic tumor microenvironment further reinforcing the activation of PSCs by stimulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f97149b4324a5a5a4e45446692fd51
https://doi.org/10.1007/s00424-017-2057-0
https://doi.org/10.1007/s00424-017-2057-0
Autor:
Otto Lindemann, Birgit Mentrup, Daniel Kronenberg, Richard Stange, Michael J. Raschke, Sebastian Klein, Manfred Fobker, Thomas Pap, J. Sherwood, Melanie Timmen
Publikováno v:
Calcified tissue international. 106(6)
Enhanced osteoclast formation and function is a fundamental cause of alterations to bone structure and plays an important role in several diseases impairing bone quality. Recent work revealed that TRP calcium channels 3 and 6 might play a special rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f783ff13e668f3e15dd35244d8e717
https://pubmed.ncbi.nlm.nih.gov/32140760
https://pubmed.ncbi.nlm.nih.gov/32140760
Publikováno v:
British Journal of Pharmacology. 171:5524-5540
Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa. This leads to the development of a tumour microenvironment with distinct physical and chemical properties that are permissive for tumour progression. The abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd19ae56e7b10a077d7374148225d854
https://doi.org/10.1111/bph.12721
https://doi.org/10.1111/bph.12721
Autor:
M. Horstmann, M. Heitzmann, F. Jung, Sandra Schimmelpfennig, C. Strodthoff, Albrecht Schwab, Nikolaj Nielsen, Otto Lindemann
Publikováno v:
Biochimica et biophysica acta. 1853(9)
Neutrophils form the first line of defense of the innate immune system and are rapidly recruited by chemotactic signals to sites of inflammation. Understanding the mechanisms of neutrophil chemotaxis is therefore of great interest for the potential d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad96cc389aadb9ee0c12d29333366a2
https://pubmed.ncbi.nlm.nih.gov/25595528
https://pubmed.ncbi.nlm.nih.gov/25595528
Autor:
Albrecht Schwab, Otto Lindemann, Sandra Schimmelpfennig, Alexander Dietrich, Svetlana Frank, Thomas Pap, Jessica Bertrand, Peter J. Hanley, Anke Fabian, Daniel Umlauf
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(11)
Unraveling the mechanisms involved in chemotactic navigation of immune cells is of particular interest for the development of new immunoregulatory therapies. It is generally agreed upon that members of the classical transient receptor potential chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc45dc0d46836dbcd4ed3964004e68a
https://pubmed.ncbi.nlm.nih.gov/23636057
https://pubmed.ncbi.nlm.nih.gov/23636057
Publikováno v:
Pflugers Archiv : European journal of physiology. 464(6)
Cell migration is crucial for many important physiological and pathophysiological processes ranging from embryogenesis to tumor metastasis. It requires the coordination of mechanical forces generated in different regions of the migrating cell. It has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2fd5b1f459d575f3681ea9993f06ee
https://pubmed.ncbi.nlm.nih.gov/23053481
https://pubmed.ncbi.nlm.nih.gov/23053481
Autor:
Simon Mohr, Mikhail A. Filippov, Francesco Di Virgilio, Otto Lindemann, Iain Chessell, Adriana del Rey, Carsten J. Kirschning, Martin Bähler, Moritz Kronlage, Peter J. Hanley, Sarah Sargin, Volker Königs, Jens Leipziger, Hermann Schillers, Albrecht Schwab
Publikováno v:
The Journal of biological chemistry. 287(13)
The function of P2X(7) receptors (ATP-gated ion channels) in innate immune cells is unclear. In the setting of Toll-like receptor (TLR) stimulation, secondary activation of P2X(7) ion channels has been linked to pro-caspase-1 cleavage and cell death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b7da95954164b74a33ff61ffc6e755
https://pubmed.ncbi.nlm.nih.gov/22235111
https://pubmed.ncbi.nlm.nih.gov/22235111