Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Otto Ka-Wing Cheung"'
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Liver cancer is the third most common cancer type and the second leading cause of deaths in men. Large population studies have demonstrated remarkable gender disparities in the incidence and the cumulative risk of liver cancer. A number of emerging r
Externí odkaz:
https://doaj.org/article/b80814156b744cd581e55e6f39e48867
Autor:
John Wong, Feng Wu, Weiqin Yang, Myth T.S. Mok, Jie Chen, Wenshu Tang, Alfred S. L. Cheng, Joseph J.Y. Sung, Anthony W.H. Chan, Ka Fai To, Zhiwei Chen, Philip Chun Yeung, Man Liu, Minhu Chen, Paul B.S. Lai, Jingying Zhou, Hongchuan Jin, Xiaoyu Liu, Xuezhen Zeng, Stephen L. Chan, Yu Feng, Hanyong Sun, Otto Ka-Wing Cheung
Publikováno v:
Gut. 69:365-379
ObjectiveHepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1ec52d60e981ae9aa02d7ba90fd841
https://doi.org/10.1136/gutjnl-2018-317257
https://doi.org/10.1136/gutjnl-2018-317257
Autor:
Paul B.S. Lai, Zhiwei Chen, Feng Wu, Hanyong Sun, Kevin Y. Yip, Jingying Zhou, Ka Fai To, Yuan Tian, Patrick Tan, Otto Ka-Wing Cheung, Alfred S. L. Cheng, Liangliang Xu, Stephen L. Chan, Wing Hung Chan, Weiqin Yang, Joseph J.Y. Sung, Yu Feng, Zhiwu Tan, John Wong
Publikováno v:
Abstracts.
Background The insufficient T cell infiltration into non-inflamed tumors such as hepatocellular carcinoma (HCC) restricts the effectiveness of immune-checkpoint blockade (ICB) to a minority of patients. Epigenetic therapy provides new opportunities t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63876849d09314170346b00aba09599d
https://doi.org/10.1136/gutjnl-2020-iddf.40
https://doi.org/10.1136/gutjnl-2020-iddf.40
Autor:
Ka Fai To, Kevin Y. Yip, Joseph J.Y. Sung, Feng Wu, Alfred S. L. Cheng, Yalin Tu, Jing Wang, Paul B.S. Lai, Zhiwei Chen, Zhiwu Tan, Yu Feng, Jianquan Cao, Hanyong Sun, Anthony W.H. Chan, Yuan Tian, Stephen L. Chan, Jingying Zhou, Weiqin Yang, Wenshu Tang, Patrick Boon-Ooi Tan, Liangliang Xu, Otto Ka-Wing Cheung, John Wong
Publikováno v:
Science translational medicine. 13(588)
Insufficient T cell infiltration into noninflamed tumors, such as hepatocellular carcinoma (HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of patients. Epigenetic therapy provides further opportunities to rewire ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f972bb2442dd3035cb4beace9ca28c
https://pubmed.ncbi.nlm.nih.gov/33827976
https://pubmed.ncbi.nlm.nih.gov/33827976
Autor:
Yuan Tian, Paul B.S. Lai, Alfred S. L. Cheng, Yaocheng Rui, Yue-Sun Cheung, Nan Li, Shu-Qun Cheng, Bo Yang, Jianjun Luo, Joseph J.Y. Sung, Pengyuan Yang, Hongyang Wang, Bin Yang, Yajing Hao, Runsheng Chen, Weiqin Yang, William K.K. Wu, Zhenxing Zhang, Otto Ka-Wing Cheung, Weinan Qiu, Zhangjun Lin
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecc04bfd9b99db0414f95fe4e677b33
http://europepmc.org/articles/PMC6662851
http://europepmc.org/articles/PMC6662851
Autor:
Stephen L. Chan, John Wong, Hanyong Sun, Anthony W.H. Chan, Weiqin Yang, Philip Chun Yeung, Man Liu, Jingying Zhou, Ka Fai To, Zhiwei Chen, Alfred S. L. Cheng, Minhu Chen, Jie Chen, Hongchuan Jin, Joseph J.Y. Sung, Yu Feng, Otto Ka-Wing Cheung, Xiaoyu Liu, Xuezhen Zeng, Feng Wu, Myth Tsz Shun Mok, Paul B.S. Lai, Wenshu Tang
Publikováno v:
Gut – IDDF Young Investigator Award.
Background Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune-checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eddccd5a770f0cf5404a54e80e839be
https://doi.org/10.1136/gutjnl-2019-iddfabstracts.4
https://doi.org/10.1136/gutjnl-2019-iddfabstracts.4
Autor:
Liangliang Xu, Wei Kang, Raymond W.M. Lung, Otto Ka-Wing Cheung, Alfred S. L. Cheng, Jinglin Zhang, Sau Dan Lee, Bo Feng, Chiou-Miin Wang, Michael W.Y. Chan, Ka Fai To, Feng Wu, Lemuel L. M. Szeto, Kevin Y. Yip, Ken H. Yu, Dae-Yeul Yu, Paul B.S. Lai, Nathalie Wong, Cheuk-Yin Lun, Tim H M Huang, Wan-Hong Huang, Qiong Wu, Jian-Liang Chou, Zhuo Yu, Myth T.S. Mok, Patrick Tan, Lei Xiong, Joseph Liu, Guangcun Huang, Yue-Sun Cheung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- and bisulfite-based whole-genome sequencing analyses reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e8f7e7fe0bded6c3095dbc889428ae
https://doi.org/10.1038/s41467-018-08245-z
https://doi.org/10.1038/s41467-018-08245-z
Autor:
Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, Feng Wu, Otto Ka-Wing Cheung, Hanyong Sun, Xuezhen Zeng, Wenshu Tang, Mok, Myth T. S., Wong, John, Chun Yeung, Philip, Bo San Lai, Paul, Zhiwei Chen, Hongchuan Jin, Jie Chen, Lam Chan, Stephen, Chan, Anthony W. H., Ka Fai To
Publikováno v:
Gut; Feb2020, Vol. 69 Issue 2, p365-379, 15p, 1 Diagram, 7 Graphs