Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Otto Jokelainen"'
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-9 (2024)
Abstract Background Inflammatory rhabdomyoblastic tumors are relatively recently recognized soft tissue tumors with a low malignant potential. Here, we present a case of concurrent inflammatory rhabdomyoblastic tumor (IRMT), adrenal pheochromocytoma,
Externí odkaz:
https://doaj.org/article/815ea49cb16e4f338b3f90461ea9fccb
Autor:
Otto Jokelainen, Teemu J. Rintala, Vittorio Fortino, Sanna Pasonen-Seppänen, Reijo Sironen, Timo K. Nykopp
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Hyaluronan (HA) accumulation in clear cell renal cell carcinoma (ccRCC) is associated with poor prognosis; however, its biology and role in tumorigenesis are unknown. RNA sequencing of 48 HA-positive and 48 HA-negative formalin-fixed paraffi
Externí odkaz:
https://doaj.org/article/776aee6536f440339bfd5fe199ef45b8
Publikováno v:
Acta Oncologica, Vol 63, Iss 1 (2024)
Background: Low computed tomography (CT)-determined muscle mass, commonly determined with height-adjusted muscle indexes (MIs), predicts worse survival in several cancers and has been suggested as a prognostic assessment tool. Although several MIs me
Externí odkaz:
https://doaj.org/article/d5f7ab5cb4c14bf5bf8d1f9918ffd870
Autor:
Anni Kujala, Elina Valkonen, Hanna Sallinen, Laura Tuppurainen, Hanne Laakso, Elias Ylä-Herttuala, Timo Liimatainen, Jouni Kujala, Otto Jokelainen, Reijo Sironen, Maarit Anttila, Seppo Ylä-Herttuala
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundVascular endothelial growth factors (VEGFs) are major regulators of intratumoral angiogenesis in ovarian cancer (OVCA). Overexpression of VEGFs is associated with increased tumor growth and metastatic tendency and VEGF-targeting therapies a
Externí odkaz:
https://doaj.org/article/9df26fe2ae0f4a789f973ce69c4105e8
Autor:
Satu Salmi, Kaisla Hälinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna Pasonen-Seppänen
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3209 (2022)
The immunosuppressive tumor microenvironment (TME) consists of suppressive cells producing a variety of immunomodulatory proteins, such as programmed death ligand 1 (PD-L1) and indoleamine-2,3-dioxygenase (IDO). Although granzyme B (GrB) is known to
Externí odkaz:
https://doaj.org/article/c980d7ff2553458faae068a3b0ec6a38
Autor:
Kai Härkönen, Sanna Oikari, Heikki Kyykallio, Janne Capra, Sini Hakkola, Kirsi Ketola, Uma Thanigai Arasu, George Daaboul, Andrew Malloy, Carla Oliveira, Otto Jokelainen, Reijo Sironen, Jaana M. Hartikainen, Kirsi Rilla
Publikováno v:
Cells, Vol 8, Iss 3, p 276 (2019)
CD44 is a multifunctional adhesion molecule typically upregulated in malignant, inflamed and injured tissues. Due to its ability to bind multiple ligands present in the tumor microenvironment, it promotes multiple cellular functions related to tumori
Externí odkaz:
https://doaj.org/article/1f935e40bb864eb1950432ca6fa63532
Autor:
Pasonen-Seppänen, Satu Salmi, Kaisla Hälinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna
Publikováno v:
Biomedicines; Volume 10; Issue 12; Pages: 3209
The immunosuppressive tumor microenvironment (TME) consists of suppressive cells producing a variety of immunomodulatory proteins, such as programmed death ligand 1 (PD-L1) and indoleamine-2,3-dioxygenase (IDO). Although granzyme B (GrB) is known to
Autor:
Otto Jokelainen, Reijo Sironen, Sirpa Aaltomaa, Markku Tammi, Sanna Pasonen-Seppänen, Arto Mannermaa, Timo K. Nykopp
Publikováno v:
Urologic oncology. 38(8)
Purpose Hyaluronan, a major glycosaminoglycan of the extracellular matrix, can act as an oncogenic component of the tumor microenvironment in many human malignancies. We characterized the hyaluronan content of renal cell carcinomas (RCCs) and investi