Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Otto Haller"'
Autor:
Benjamin Mänz, Dominik Dornfeld, Veronika Götz, Roland Zell, Petra Zimmermann, Otto Haller, Georg Kochs, Martin Schwemmle
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003279 (2013)
The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer Mx
Externí odkaz:
https://doaj.org/article/0a0e3f90f75844209ed02fed6b1fbe38
Autor:
Georg Kochs, Yuelong Shu, Jian Lu, Qijun Liao, Y. Chen, Tian Bai, Lei Yang, Wenfei Zhu, Otto Haller, Philipp P. Petric, Peter Staeheli, Juan Shen, Tao Chen, Martin Schwemmle, Laura Graf, Jie Dong, Dayan Wang, Ying Chen
Publikováno v:
Science. 373:918-922
Poultry passport to pandemic What conditions are required to nurture the seeds of a pandemic? The avian influenza virus H7N9 rarely spills over into humans, but when it does, mortality exceeds 30%, far in excess of that of severe acute respiratory sy
Autor:
Otto Haller, Georg Kochs
Publikováno v:
Human Genetics. 139:695-705
The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating a key role of human MxA for host survival
Autor:
Yongkun, Chen, Laura, Graf, Tao, Chen, Qijun, Liao, Tian, Bai, Philipp P, Petric, Wenfei, Zhu, Lei, Yang, Jie, Dong, Jian, Lu, Ying, Chen, Juan, Shen, Otto, Haller, Peter, Staeheli, Georg, Kochs, Dayan, Wang, Martin, Schwemmle, Yuelong, Shu
Publikováno v:
Science (New York, N.Y.). 373(6557)
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing to compare avian IAV H7N9 patients with healthy c
Autor:
Sébastien, Soubies, Otto, Haller
Publikováno v:
Virologie (Montrouge, France). 18(2)
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking early steps in the viral replication cycle. Recent evidence suggests that the human MxA (MX1) protein provides a
Autor:
Christoph M. Deeg, Ebrahim Hassan, Sébastien M. Soubies, Linda Magar, Lara Rheinemann, Georg Kochs, Veronika Götz, Pascal Mutz, Cindy Nürnberger, Martin Schwemmle, Peter Staeheli, Carsten Kallfass, Mirjam Schilling, Otto Haller
Publikováno v:
The Journal of Experimental Medicine
Deeg et al. show a novel line of transgenic mice expressing restriction factor MxA exhibits robust resistance to influenza viruses of avian but not human origin. In vivo evasion of MxA is mediated by distinct amino acids in the nucleoprotein of human
Publikováno v:
Annual review of virology. 5(1)
The discovery of the Mx gene–dependent, innate resistance of mice against influenza virus was a matter of pure chance. Although the subsequent analysis of this antiviral resistance was guided by straightforward logic, it nevertheless led us into ma
Publikováno v:
Trends in Microbiology. 23:154-163
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functio
Autor:
Otto Haller
Publikováno v:
Cytokine. 76:113-115
In 1957, the discovery of interferon was reported by Isaacs and Lindenmann in the prestigious journal Proceedings of the Royal Society (1957) [1,2]. This discovery was definitely one of the scientific landmarks in cell biology of the past century. It
MxA gene expression is known to be regulated tightly and exclusively by type I interferons (IFNs). The kinetics of MxA gene expression was analyzed in peripheral blood mononuclear cells from 11 healthy volunteers vaccinated with the 17-D strain of ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bdaaa34c45b5d7e1d74016790e1c35
http://doc.rero.ch/record/299088/files/169-4-807.pdf
http://doc.rero.ch/record/299088/files/169-4-807.pdf