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Akademický článek

Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children

Autor: Rinaldo Puga-Gómez, Yariset Ricardo-Delgado, Chaumey Rojas-Iriarte, Leyanis Céspedes-Henriquez, Misleidys Piedra-Bello, Dania Vega-Mendoza, Noelvia Pestana Pérez, Beatriz Paredes-Moreno, Meiby Rodríguez-González, Carmen Valenzuela-Silva, Belinda Sánchez-Ramírez, Laura Rodríguez-Noda, Rocmira Pérez-Nicado, Raul González-Mugica, Tays Hernández-García, Talía Fundora-Barrios, Martha Dubet Echevarría, Juliet María Enriquez-Puertas, Yenicet Infante-Hernández, Ariel Palenzuela-Díaz, Evelyn Gato-Orozco, Yanet Chappi-Estévez, Julio Cesar Francisco-Pérez, Miladi Suarez-Martinez, Ismavy C. Castillo-Quintana, Sonsire Fernandez-Castillo, Yanet Climent-Ruiz, Darielys Santana-Mederos, Yanelda García-Vega, María Eugenia Toledo-Romani, Delaram Doroud, Alireza Biglari, Yury Valdés-Balbín, Dagmar García-Rivera, Vicente Vérez-Bencomo, María Elena Mesa-Herrera, Yarmila García-Cristiá, Leonor Verdecia-Sánchez, Rafael del Valle Rodríguez, Yudalvies Oquendo-de la Cruz, Daysi Álvarez-Montalvo, Randy Grillo-Fortún, Liset López-González, Omaida Fonte Galindo, Yeseni Reyes-González, Ana Beatriz González-Álvarez, Linet Gorrita-Mora, Rodrigo Valera-Fernández, Ivis Ontivero-Pino, Marisel Martínez-Pérez, Esperanza Caballero-Gonzalez, Aniurka Garcés-Hechavarría, Dayle Martínez-Bedoya, Maite Medina-Nápoles, Yeney Regla Domínguez-Pentón, Yadira Cazañas-Quintana, Thais Fundora Barrios, Diana R. Hernández Fernández, Gretchen Bergado-Báez, Ivette Orosa-Vazquez, Franciscary Pi-Estopiñan, Marianniz Díaz-Hernández, Otto Cruz-Sui, Enrique Noa-Romero, Arilia García-López, Sandra Rivadereira Muro, Gerardo Baro-Roman

Publikováno v: International Journal of Infectious Diseases, Vol 126, Iss , Pp 164-173 (2023)

Objectives: To evaluate a heterologous vaccination scheme in children 3-18 years old (y/o) combining two SARS-CoV-2r- receptor binding domain (RBD)protein vaccines. Methods: A phase I/II open-label, adaptive, and multicenter trial evaluated the safet

Externí odkaz: https://doaj.org/article/88ee0659b0bf4cf3888a8d4fcd8fc08e

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Akademický článek

Organizational experience of the Civil Defense Scientific Research Center in the diagnosis of COVID-19

Autor: Mireida Rodríguez Acosta, Marta Dubed Echevarría, María Teresa Pérez Guevara, Otto Cruz Sui, Nibaldo Luis González Sosa, Tamara Hernández Sánchez, José Ángel Columbié Gamboa, Alejandro Velázquez Pupo

Publikováno v: Revista Cubana de Medicina Militar, Vol 50, Iss 2, Pp e02101326-e02101326 (2021)

Facing the COVID-19 epidemic in Cuba has required the development of new capacities for its diagnosis in the molecular biology laboratories of different scientific and health institutions. The objective of this work is to show the experience of the C

Externí odkaz: https://doaj.org/article/1434f1344eb44716b8af9957e75dd061

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Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis

Autor: Viviana Falcón-Cama, Teresita Montero-González, Emilio F. Acosta-Medina, Gerardo Guillen-Nieto, Jorge Berlanga-Acosta, Celia Fernández-Ortega, Anabel Alfonso-Falcón, Nathalie Gilva-Rodríguez, Lilianne López-Nocedo, Daina Cremata-García, Mariuska Matos-Terrero, Giselle Pentón-Rol, Iris Valdés, Leonardo Oramas-Díaz, Anamarys Suarez-Batista, Enrique Noa-Romero, Otto Cruz-Sui, Daisy Sánchez, Amanda I. Borrego-Díaz, Juan E. Valdés-Carreras, Ananayla Vizcaino, José Suárez-Alba, Rodolfo Valdés-Véliz, Gretchen Bergado, Miguel A. González, Tays Hernandez, Rydell Alvarez-Arzola, Anna C. Ramírez-Suárez, Dionne Casillas-Casanova, Gilda Lemos-Pérez, Omar R. Blanco-Águila, Angelina Díaz, Yorexis González, Mónica Bequet-Romero, Javier Marín-Prida, Julio C. Hernández-Perera, Leticia del Rosario-Cruz, Alina P. Marin-Díaz, Maritza González-Bravo, Israel Borrajero, Nelson Acosta-Rivero

Publikováno v: Archives of Virology. 168

There is an urgent need to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions involved in virus spread and pathogenesis, which might contribute to the identification of new therapeutic targets. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a1d34a5fbccf8d846cd8ceae38da584
https://doi.org/10.1007/s00705-023-05711-y

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Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme

BackgroundSOBERANA 02 is a COVID-19 conjugate vaccine candidate based on SARS-CoV-2 recombinant RBD conjugated to tetanus toxoid. SOBERANA Plus antigen is dimeric-RBD. Here we report safety, reactogenicity and immunogenicity from phase I and IIa clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585980601f45319168ec11e934bb3723
https://doi.org/10.1101/2021.11.14.21266309

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Safety and immunogenicity of anti-SARS-CoV-2 heterologous scheme with SOBERANA 02 and SOBERANA Plus vaccines: Phase IIb clinical trial in adults

Autor: María Eugenia Toledo-Romani, Mayra García-Carmenate, Leslyhana Verdecia-Sánchez, Suzel Pérez-Rodríguez, Meybis Rodriguez-González, Carmen Valenzuela-Silva, Beatriz Paredes-Moreno, Belinda Sanchez-Ramirez, Raúl González-Mugica, Tays Hernández-Garcia, Ivette Orosa-Vázquez, Marianniz Díaz-Hernández, María Teresa Pérez-Guevara, Juliet Enriquez-Puertas, Enrique Noa-Romero, Ariel Palenzuela-Diaz, Gerardo Baro-Roman, Ivis Mendoza-Hernández, Yaima Muñoz, Yanet Gómez-Maceo, Bertha Leysi Santos-Vega, Sonsire Fernandez-Castillo, Yanet Climent-Ruiz, Laura Rodríguez-Noda, Darielys Santana-Mederos, Yanelda García-Vega, Guang-Wu Chen, Delaram Doroud, Alireza Biglari, Tammy Boggiano-Ayo, Yury Valdés-Balbín, Daniel G. Rivera, Dagmar García-Rivera, Vicente Vérez-Bencomo, Mailin Cubas-Curbelo, Pedro Gabriel Rodríguez-Castillo, Yosmel Acevedo-Martínez, Solangel Estoque-Cabrera, José Alejandro Ávila-Cabreja, Ainadis Alfaro-Guzmán, Lilian Zulueta-Pérez, Niurka Tamara Espino-Rojas, Gloria Margarita Medinas-Santos, Ileana Luisa Sarda-Rodriguez, Mario Alejandro Acosta-Martinez, Radamet Reyes-Matienzo, José Manuel Coviella-Artime, Irania Morffi-Cinta, Marisel Martínez-Pérez, Rodrigo Valera-Fernández, Aniurka Garcés-Hechavarría, Dayle Martínez-Bedoya, Raine Garrido-Arteaga, Félix Cardoso-SanJorge, Ubel Ramírez-Gonzalez, Lauren Quintero-Moreno, Ivis Ontivero-Pino, Roselyn Martínez-Rivera, Berta Guillén-Obregón, Janet Lora-García, Maite Medina-Nápoles, Jennifer Espi-Ávila, Marcos Fontanies-Fernández, Yeney Regla Domínguez-Pentón, Gretchen Bergado-Baez, Franciscary Pi-Estopiñán, Eduardo Ojito-Magaz, Misladys Rodríguez, Otto Cruz-Sui, Majela García-Montero, Marta Dubed-Echevarría, Elena García-López, Evelyn Galano-Frutos, Alina Perez-Perez, Susana Morales-Ruano, Idalmis Brito-Pascual, Maité Amoroto, Amaylid Arteaga-García

Publikováno v: Med. 3:760-773.e5

SOBERANA 02 has been evaluated in phase I and IIa studies comparing homologous versus heterologous schedule (this one, including SOBERANA Plus). Here, we report results of immunogenicity, safety, and reactogenicity of SOBERANA 02 in a two- or three-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d992db15fcafc31e61303944700136e9
https://doi.org/10.1016/j.medj.2022.08.001

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An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen

Publikováno v: New biotechnology. 72

Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic. Here the development is reported of a vaccine based on the SARS-CoV-2 receptor-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d88d43355ae99999dd9859c81e5ec47
https://pubmed.ncbi.nlm.nih.gov/35953030

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The SARS-CoV-2 receptor-binding domain expressed in Pichia pastoris as a candidate vaccine antigen

1.AbstractThe effort to develop vaccines based on economically accessible technological platforms available by developing countries vaccine manufacturers is essential to extend the immunization to the whole world population and to achieve the desired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00752b7d5bd5d4c033823e3359691b90
https://doi.org/10.1101/2021.06.29.21259605

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Akademický článek

Seroprevalencia de la infección por HTLV-1 en diferentes grupos de riesgo estudiados en Cuba

Autor: Ana Luisa Lubián Caballero, Héctor Manuel Díaz Torres, Eladio Silva Cabrera, María Teresa Pérez Guevara, Otto Cruz Sui, José Luis de la Fuente Arzola, Leonor Navea Leyva, Enrique Noa Romero

Publikováno v: Revista Cubana de Medicina, Vol 37, Iss 4, Pp 199-204 (1998)

Se estudiaron, en el período comprendido desde 1991 hasta 1996, 26 352 muestras de suero procedentes de diferentes grupos de riesgo y donantes de sangre para conocer la seroprevalencia de anticuerpos contra el virus linfotrópico de las células T h

Externí odkaz: https://doaj.org/article/d0a0574236e14b7495cf22877d6a1df4

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