Freezing medium containing 5% DMSO enhances the cell viability and recovery rate after cryopreservation of regulatory T cell products ex vivo and in vivo

Autor: Kaiser, D, Otto, NM, McCallion, O, Hoffmann, H, Zarrinrad, G, Stein, M, Beier, C, Matz, I, Herschel, M, Hester, J, Moll, G, Issa, F, Reinke, P, Roemhild, A

Cell therapies have significant therapeutic potential in diverse fields including regenerative medicine, transplantation tolerance, and autoimmunity. Within these fields, regulatory T cells (Treg) have been deployed to ameliorate aberrant immune resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::2bef079de2f6bc86b4a73d924f4ea0b8
https://ora.ox.ac.uk/objects/uuid:f147f37f-55eb-4bae-ab26-48fa3bd0e61e

Vicinal glutamates are better phosphomimetics: Phosphorylation is required for allosteric activation of guanylyl cyclase-A.

Autor: Otto NM; Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, Minneapolis, MN, United States., Potter LR; Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, Minneapolis, MN, United States.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Nov 04; Vol. 15, pp. 1012784. Date of Electronic Publication: 2022 Nov 04 (Print Publication: 2022).

Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo .

Autor: Kaiser D; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Otto NM; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology and Internal Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany., McCallion O; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom., Hoffmann H; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Zarrinrad G; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Stein M; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Beier C; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Matz I; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Herschel M; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Hester J; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom., Moll G; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany., Issa F; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom., Reinke P; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology and Internal Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany., Roemhild A; Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Dec 03; Vol. 9, pp. 750286. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

Autor: Sawitzki B; Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany., Harden PN; Oxford Transplantation Centre, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Reinke P; BeCAT, BCRT, and Department of Nephrology & Intensive Care, Charité Universitätsmedizin Berlin, and Berlin Institute of Health, Berlin, Germany., Moreau A; Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France., Hutchinson JA; Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Game DS; Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK., Tang Q; Division of Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Guinan EC; Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston MA, USA., Battaglia M; Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy., Burlingham WJ; Division of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Roberts ISD; Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Streitz M; Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany., Josien R; Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France; Laboratoire d'Immunologie, Cimna, Centre Hospitalier Universitaire, Nantes, France., Böger CA; Department of Nephrology, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Scottà C; MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK., Markmann JF; Center for Transplantation Sciences, Mass General Hospital, Boston, MA, USA., Hester JL; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Juerchott K; BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany., Braudeau C; Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France; Laboratoire d'Immunologie, Cimna, Centre Hospitalier Universitaire, Nantes, France., James B; Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany., Contreras-Ruiz L; Department of Experimental Medicine, DFCI, Boston, MA, USA., van der Net JB; Oxford Transplantation Centre, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Bergler T; Department of Nephrology, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Caldara R; Transplant Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy., Petchey W; Oxford Transplantation Centre, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Edinger M; Department of Internal Medicine III, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Dupas N; Beckman Coulter Life Sciences, Immunotech, Marseille, France., Kapinsky M; Beckman Coulter, Krefeld, Germany., Mutzbauer I; Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany., Otto NM; BeCAT, BCRT, and Department of Nephrology & Intensive Care, Charité Universitätsmedizin Berlin, and Berlin Institute of Health, Berlin, Germany., Öllinger R; Department of Surgery, Charité Campus Mitte, Campus Virchow Klinikum, Charité Universitätsmedizin, Berlin, Germany., Hernandez-Fuentes MP; MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK., Issa F; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Ahrens N; Institute for Clinical Chemistry and Laboratory Medicine, Transfusion Medicine, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Meyenberg C; KOEHLER eClinical, Freiburg, Germany., Karitzky S; Miltenyi Biotec, Bergisch Gladbach, Germany., Kunzendorf U; Clinic for Nephrology and Hypertension, Christian Albrechts University, University Clinic Schleswig-Holstein, Kiel, Germany., Knechtle SJ; Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, USA., Grinyó J; Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, IDIBELL, Barcelona University, Barcelona, Spain., Morris PJ; Centre for Evidence in Transplantation, Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Brent L; St Mary's Hospital Transplant Unit, Paddington, London, UK., Bushell A; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Turka LA; Center for Transplantation Sciences, Mass General Hospital, Boston, MA, USA., Bluestone JA; UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Lechler RI; MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK., Schlitt HJ; Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Cuturi MC; Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France., Schlickeiser S; Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany., Friend PJ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Miloud T; Beckman Coulter Life Sciences, Immunotech, Marseille, France., Scheffold A; Institute for Immunology, Christian Albrechts University, University Clinic Schleswig-Holstein, Kiel, Germany., Secchi A; Vita-Salute San Raffaele University Milan, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy., Crisalli K; Center for Transplantation Sciences, Mass General Hospital, Boston, MA, USA., Kang SM; Division of Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Hilton R; Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK., Banas B; Department of Nephrology, University of Regensburg, University Hospital Regensburg, Regensburg, Germany., Blancho G; Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France., Volk HD; Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany., Lombardi G; MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK., Wood KJ; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Geissler EK; Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany. Electronic address: edward.geissler@klinik.uni-regensburg.de.

Publikováno v: Lancet (London, England) [Lancet] 2020 May 23; Vol. 395 (10237), pp. 1627-1639.

Preformed donor-reactive T cells that persist after ABO desensitization predict severe T cell-mediated rejection after living donor kidney transplantation - a retrospective study.

Autor: Schachtner T; Department of Nephrology and Internal Intensive Care, Charité University Medicine Berlin, Berlin, Germany.; Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany.; Department of Nephrology, University Hospital Zurich, Zurich, Switzerland., Stein M; Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany., Otto NM; Department of Nephrology and Internal Intensive Care, Charité University Medicine Berlin, Berlin, Germany.; Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany., Reinke P; Department of Nephrology and Internal Intensive Care, Charité University Medicine Berlin, Berlin, Germany.; Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany.

Publikováno v: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2020 Mar; Vol. 33 (3), pp. 288-297. Date of Electronic Publication: 2019 Nov 26.