Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Ottmar, Janssen"'
Publikováno v:
Cells, Vol 13, Iss 20, p 1745 (2024)
Background: Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin. The effector proteins are stored in differe
Externí odkaz:
https://doaj.org/article/ec083a591c284b1eae2901f3b49dbf9a
Publikováno v:
Cells, Vol 13, Iss 16, p 1310 (2024)
Background: Large granular lymphocyte leukemias (LGLLs) are rare lymphoproliferative malignancies caused by clonal expansion of granular lymphocytes. T-cell LGLL and natural killer (NK) cell LGLL are defined based on their cellular origin. Their clin
Externí odkaz:
https://doaj.org/article/8f90bbd3014c49319670b7464b0818d3
Autor:
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jörg P. Weimer, Inken Flörkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag, Nina Hedemann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 7, Pp n/a-n/a (2023)
Abstract Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect chemoresistance and cancer cell‐derived extracellular vesicles (EV). The mechanisms of how
Externí odkaz:
https://doaj.org/article/b608a4f57c4247b186f7a69bb4075f92
Autor:
Thaís Dolzany de Oliveira, Alexander vom Stein, Rocio Rebollido-Rios, Liudmila Lobastova, Marcus Lettau, Ottmar Janssen, Prerana Wagle, Phuong-Hien Nguyen, Michael Hallek, Hinrich P. Hansen
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
IntroductionIn chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles (EVs). The protein tyrosine kinase Lyn is aberrantly expressed in t
Externí odkaz:
https://doaj.org/article/3236639ca318479aadab9276f50874a5
Autor:
Marcus Lettau, Ottmar Janssen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells utilize an overlapping effector arsenal for the elimination of target cells. It was initially proposed that all cytotoxic effector proteins are stored in lysosome-related effector vesicles (
Externí odkaz:
https://doaj.org/article/67926a77eb4141b9b3658faa512bb558
Autor:
Liudmila Lobastova, Marcus Lettau, Felix Babatz, Thais Dolzany de Oliveira, Phuong-Hien Nguyen, Bianca Alves Pauletti, Astrid C. Schauss, Horst Dürkop, Ottmar Janssen, Adriana F. Paes Leme, Michael Hallek, Hinrich P. Hansen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
CD30, a member of the TNF receptor superfamily, is selectively expressed on a subset of activated lymphocytes and on malignant cells of certain lymphomas, such as classical Hodgkin Lymphoma (cHL), where it activates critical bystander cells in the tu
Externí odkaz:
https://doaj.org/article/ee4ad5abc83c476f806f4f05d2d13b45
Autor:
Birthe Bernicke, Nils Engelbogen, Katharina Klein, Jeanette Franzenburg, Christoph Borzikowsky, Christian Peters, Ottmar Janssen, Ralf Junker, Ruben Serrano, Dieter Kabelitz
Publikováno v:
Cells, Vol 11, Iss 9, p 1460 (2022)
In addition to its role in bone metabolism, vitamin D3 exerts immunomodulatory effects and has been proposed to contribute to seasonal variation of immune cells. This might be linked to higher vitamin D3 levels in summer than in winter due to differe
Externí odkaz:
https://doaj.org/article/b0d85ce058da4789a0f09847fad89282
Autor:
Christian Peters, Annika Meyer, Léonce Kouakanou, Julia Feder, Tim Schricker, Marcus Lettau, Ottmar Janssen, Daniela Wesch, Dieter Kabelitz
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of induced regulatory T cells (iTreg) but also in the polarization of interleukin-9 (IL-9) prod
Externí odkaz:
https://doaj.org/article/bcd87d3c50084819a55780a1dcfc32fd
Autor:
Dana Hellmold, Carolin Kubelt, Tina Daunke, Silje Beckinger, Ottmar Janssen, Margarethe Hauck, Fabian Schütt, Rainer Adelung, Ralph Lucius, Jochen Haag, Susanne Sebens, Michael Synowitz, Janka Held-Feindt
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 9075
Glioblastoma (GBM) is a poorly treatable disease due to the fast development of tumor recurrences and high resistance to chemo- and radiotherapy. To overcome the highly adaptive behavior of GBMs, especially multimodal therapeutic approaches also incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c043435b0c11c9a1f74f265104b2055c
Autor:
Guranda Chitadze, Charlotte Flüh, Elgar Susanne Quabius, Sandra Freitag-Wolf, Christian Peters, Marcus Lettau, Jaydeep Bhat, Daniela Wesch, Hans-Heinrich Oberg, Stefanie Luecke, Ottmar Janssen, Michael Synowitz, Janka Held-Feindt, Dieter Kabelitz
Publikováno v:
OncoImmunology, Vol 6, Iss 11 (2017)
Despite aggressive treatment regimens based on surgery and radiochemotherapy, the prognosis of patients with grade IV glioblastoma multiforme (GBM) remains extremely poor, calling for alternative options such as immunotherapy. Immunological mechanism
Externí odkaz:
https://doaj.org/article/2b83e49bb3d54e9099b1ad92a449de09