Systematic identification of signaling pathways with potential to confer anticancer drug resistance.

Autor: Martz CA; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Ottina KA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA., Singleton KR; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Jasper JS; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Peraza-Penton A; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Wang T; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA., Alley HM; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Kwong LN; University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA., Cooper ZA; University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA., Tetzlaff M; University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA., Chen PL; University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA., Rathmell JC; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Flaherty KT; Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA., Wargo JA; University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA., Sabatini DM; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. sabatini@wi.mit.edu kris.wood@duke.edu., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, 450 Research Drive, Durham, NC 27710, USA. sabatini@wi.mit.edu kris.wood@duke.edu.

Publikováno v: Science signaling [Sci Signal] 2014 Dec 23; Vol. 7 (357), pp. ra121. Date of Electronic Publication: 2014 Dec 23.

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Autor: Hsu PP; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA., Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM

Publikováno v: Science (New York, N.Y.) [Science] 2011 Jun 10; Vol. 332 (6035), pp. 1317-22.