Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ottilia Balázs"'
Autor:
Bence Farkas, Pálma Diószegi, Balázs Lendvai, Gabriella Nyitrai, András Czurkó, Ottilia Balázs, Bela Kiss
Publikováno v:
Journal of Psychopharmacology. 35:303-310
Background: Cariprazine is a dopamine D3-preferring D3/D2 receptor partial agonist compound recently introduced to treat schizophrenia and bipolar disorder. Although cariprazine is clinically classified as a low-somnolence drug, to date no detailed p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a02b2fe918c90b18622f8822d5f7ee
https://doi.org/10.1177/0269881120981378
https://doi.org/10.1177/0269881120981378
Autor:
Ottilia Balázs, Károly Fazekas, Balázs Lendvai, Zsolt Némethy, Katalin Saghy, Istvan Gyertyan, Bence Farkas, Etelka Bolf-Terjéki, Bela Kiss, Dalma Kurkó, Norbert Antal Kirschner, István Laszlovszky
Publikováno v:
Drug Design, Development and Therapy. 13:3229-3248
Introduction Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, has two major human metabolites, desmethyl-cariprazine (DCAR) and didesmethyl-cariprazine (DDCAR). The metabolite pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8aea3c4b8b6fbbb53c87fd7c077f53f
https://doi.org/10.2147/dddt.s188760
https://doi.org/10.2147/dddt.s188760
Autor:
Zsolt, Némethy, Béla, Kiss, Natasha, Lethbridge, Paul, Chazot, Tünde, Hajnik, Attila, Tóth, László, Détári, Éva, Schmidt, András, Czurkó, Diána, Kostyalik, Vilmos, Oláh, István, Hernádi, Ottilia, Balázs, E Sylvester, Vizi, István, Ledneczki, Sándor, Mahó, Viktor, Román, Balázs, Lendvai, György, Lévay
Publikováno v:
European journal of pharmacology. 916
The histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d00db9c21eae4a299c02b5487aa1036b
https://pubmed.ncbi.nlm.nih.gov/34965389
https://pubmed.ncbi.nlm.nih.gov/34965389
Autor:
Zsolt Némethy, Béla Kiss, Natasha Lethbridge, Paul Chazot, Tünde Hajnik, Attila Tóth, László Détári, Éva Schmidt, András Czurkó, Diána Kostyalik, Vilmos Oláh, István Hernádi, Ottilia Balázs, E. Sylvester Vizi, István Ledneczki, Sándor Mahó, Viktor Román, Balázs Lendvai, György Lévay
Publikováno v:
European Journal of Pharmacology. 916:174621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1beae2435563c1ece7c1fadf0cc0b9b3
https://doi.org/10.1016/j.ejphar.2021.174621
https://doi.org/10.1016/j.ejphar.2021.174621
Autor:
Zsolt Némethy, Balázs Lendvai, Balázs Krámos, Katalin Dudás Molnár, Ottilia Balázs, Anita Horváth, Áron Szigetvári, György Lévay, János Kóti, János Éles, Istvan Vago, István Ledneczki, András Visegrády, Mónika Vastag, Marta Than, Pál Tapolcsányi, Diána Kostyalik, Sándor Mahó, Sándor Kolok, Patrik Holm, László Fodor, István Greiner, László Kiss
Publikováno v:
European Journal of Medicinal Chemistry. 222:113560
HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25756ef61e702aa21bdd1b8a5b62e5bf
https://doi.org/10.1016/j.ejmech.2021.113560
https://doi.org/10.1016/j.ejmech.2021.113560
Autor:
Viktor Román, Pál Tapolcsányi, György Lévay, István Greiner, István Ledneczki, János Éles, Rita Kedves, Sándor Mahó, Eszter Gábor, Ottilia Balázs, Eva Schmidt, Zsolt Némethy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4525-4530
Emerging from an HTS campaign, novel steroid-based histamine H3 receptor antagonists were identified and characterized. Structural moieties of the hit compounds were combined to improve binding affinities which resulted in compound 4 as lead molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8bdc6b2dbb983ae0f39a39b3fd260e
https://doi.org/10.1016/j.bmcl.2017.08.060
https://doi.org/10.1016/j.bmcl.2017.08.060
Autor:
Attila Sándor Halász, Amrita Ágnes Bobok, Zoltán Szakács, István Greiner, Zoltán Orgován, Mónika Vastag, Sándor Kolok, Zoltán Béni, Gábor Wágner, Mónika L. Mikó-Bakk, Zsolt Szombathelyi, Attila Bielik, Krisztina Gál, Katalin Nogradi, György M. Keserű, Ottilia Balázs, Katalin Saghy, János Kóti, György T. Balogh, Judit Laszy, Mikhail Krasavin, György Domány, Janos Galambos
Publikováno v:
Journal of Medicinal Chemistry. 60:2470-2484
Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been implicated as a potential pharmacotherapy for a number of psychiatric diseases, including anxiety and depression. Most of the mGluR5 NAM clinical candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3dc984e3e83f573a4bc24f797febd2
https://doi.org/10.1021/acs.jmedchem.6b01858
https://doi.org/10.1021/acs.jmedchem.6b01858
Autor:
István, Ledneczki, Zsolt, Némethy, Pál, Tapolcsányi, János, Éles, István, Greiner, Eszter, Gábor, Balázs, Varga, Ottilia, Balázs, Viktor, Román, György, Lévay, Sándor, Mahó
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(20)
To further proceed with our previous work, novel steroid-based histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f06502bad9ee854fbc29e3e4e010a5f
https://pubmed.ncbi.nlm.nih.gov/31492518
https://pubmed.ncbi.nlm.nih.gov/31492518
Autor:
Balázs Lendvai, Anna E. Káncz, Pál Tapolcsányi, Zoltán Béni, János Kóti, Marta Than, Éva Bozó, János Éles, István Greiner, Judit Laszy, Zsolt Némethy, Sándor Mahó, András Visegrády, Márton Vass, Gyula Bugovits, György Lévay, István Ledneczki, Anikó Pocsai, Balázs Krámos, Ágota Szájli, Mónika Vastag, Patrik Holm, Sándor Kolok, Eszter Gábor, Ottilia Balázs, Anita Horváth, József Nagy
Publikováno v:
European Journal of Medicinal Chemistry. 214:113189
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts were carried out to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad9ffda37f8a3d089c88187d8a3c0f
https://doi.org/10.1016/j.ejmech.2021.113189
https://doi.org/10.1016/j.ejmech.2021.113189
Autor:
Béla, Kiss, Zsolt, Némethy, Károly, Fazekas, Dalma, Kurkó, István, Gyertyán, Katalin, Sághy, István, Laszlovszky, Bence, Farkas, Norbert, Kirschner, Etelka, Bolf-Terjéki, Ottilia, Balázs, Balázs, Lendvai
Publikováno v:
Drug Design, Development and Therapy
Introduction: Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, has two major human metabolites, desmethyl-cariprazine (DCAR) and didesmethyl-cariprazine (DDCAR). The metabolite pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::739e80d6fb74c315ac808a322cbcc57c
https://pubmed.ncbi.nlm.nih.gov/31571826
https://pubmed.ncbi.nlm.nih.gov/31571826