Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

Autor: Awoniyi, DO, Teuchert, A, Sutherland, JS, Mayanja-Kizza, H, Howe, R, Mihret, A, Loxton, AG, Sheehama, J, Kassa, D, Crampin, AC, Dockrell, HM, Kidd, M, Rosenkrands, I, Geluk, A, Ottenhoff, TH, Corstjens, PL, Chegou, NN, Walzl, G, AE-TBC Consortium, COLLABORATORS, Kriel, M, van der Spuy, G, Stanley, K, Malherbe, S, Mcanda, S, Kriel, B, Phalane, KG, Essone, P, Owolabi, O, Sillah, A, Mendy, J, Gindeh, A, Donkor, S, Togun, T, Ota, M, Simukonda, F, Amberbir, A, Chilongo, F, Houben, R, Gebrezgeabher, A, Mesfin, G, Belay, Y, Gebremichael, G, Alemayehu, Y, van der Vyver, M, Amutenya, FN, Nelongo, JN, Monye, L, Sheehama, JA, Iipinge, S, Namuganga, AR, Muzanye, G, Nsereko, M, Peters, P, Bekele, Y, Tessema, B, Yamuah, L, Franken, K, Tjon Kon Fat, EM, de Dood, CJ, van der Ploeg-van Schip, JJ, Aagaard, C, Kaufmann, SH, Esterhuyse, MM, Cliff, JM

We investigated the accuracy of host markers detected in Mtb antigen-stimulated whole blood culture supernatant in the diagnosis of TB. : Prospectively, blood from 322 individuals with presumed TB disease from six African sites was stimulated with fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::995f50199fe9304958c83397c73b9576

Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection

Autor: Greco E, Quintiliani G, Santucci MB, Serafino A, Ciccaglione AR, Marcantonio C, Papi M, Maulucci G, Delogu G, Martino A, Goletti D, Sarmati L, Andreoni M, Altieri A, Alma M, Caccamo N, Di Liberto D, De Spirito M, Savage ND, Nisini R, Dieli F, Ottenhoff TH: Fraziano M

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America (Online) 109 (2012): E1360-8.
info:cnr-pdr/source/autori:Greco E; Quintiliani G; Santucci MB; Serafino A; Ciccaglione AR; Marcantonio C; Papi M; Maulucci G; Delogu G; Martino A; Goletti D; Sarmati L; Andreoni M; Altieri A; Alma M; Caccamo N; Di Liberto D; De Spirito M; Savage ND; Nisini R; Dieli F; Ottenhoff TH: Fraziano M/titolo:Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection./doi:/rivista:Proceedings of the National Academy of Sciences of the United States of America (Online)/anno:2012/pagina_da:E1360-8/pagina_a:/intervallo_pagine:E1360-8/volume:109

We have generated unique asymmetric liposomes with phosphatidylserine (PS) distributed at the outer membrane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner layer as a strategy to enhance innate antimycobacterial activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::529fcdbcc73d776c6daff334073e819a
https://publications.cnr.it/doc/188250

Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population.

Autor: Sahiratmadja E, Wieringa FT, van Crevel R, de Visser AW, Adnan I, Alisjahbana B, Slagboom E, Marzuki S, Ottenhoff TH, van de Vosse E, Marx JJ

Publikováno v: British Journal of Nutrition; Oct2007, Vol. 98 Issue 4, p684-690, 7p

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

Autor: Alfredo Salerno, Alessandro Sanduzzi, Domenico Galati, Alessandro Matarese, Lucina Titone, Marialuisa Bocchino, Michèl R. Klein, Francesco Dieli, Tom H. M. Ottenhoff, Giuseppe Gelsomino, Paola Di Carlo, Jan Nouta, Nadia Caccamo, Serena Meraviglia, Giuliana Guggino

Publikováno v: PLoS ONE, Vol 4, Iss 5, p e5528 (2009)
PLoS ONE

CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with active tuberculosis disease. CD8 T-cells recognizing ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b33e1fee2be37c0ae385f094fbe93ca
http://europepmc.org/articles/PMC2678250?pdf=render

Genome-based in silico identification of new Mycobacterium tuberculosis antigens activating polyfunctional CD8+ T cells in human tuberculosis

Autor: Sheila Tuyet Tang, Nadia Caccamo, Fatima Kazi, Ugur Sahin, Francesco Dieli, Ole Lund, Michèl R. Klein, Alexander Dr. Zaigler, Søren Buus, Pascale van Weeren, Tom H. M. Ottenhoff, Giuliana Guggino, Krista E. van Meijgaarden, Anette Stryhn

Publikováno v: Journal of Immunology, 186(2), 1068-1080
The Journal of Immunology
The Journal of Immunology; Vol 186

Although CD8(+) T cells help control Mycobacterium tuberculosis infection, their M. tuberculosis Ag repertoire, in vivo frequency, and functionality in human tuberculosis (TB) remains largely undefined. We have performed genome-based bioinformatics s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44629ef3183d0863699b1f935df072fa
https://pubmed.ncbi.nlm.nih.gov/21169544