MECHANISMS OF MRP OVER-EXPRESSION IN 4 HUMAN LUNG-CANCER CELL-LINES AND ANALYSIS OF THE MRP AMPLICON

Autor: EIJDEMS, EWHM, DEHAAS, M, COCOMARTIN, JM, OTTENHEIM, CPE, ZAMAN, GJR, DAUWERSE, HG, BREUNING, MH, TWENTYMAN, PR, BORST, P, BAAS, F

Publikováno v: International Journal of Cancer, 60(5), 676-684. Wiley

Some multidrug resistant cell lines over-express the gene encoding the multidrug-resistance-associated protein (MRP). In all cell lines reported thus far, over-expression is associated with gene amplification. We have studied the predominant mechanis

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https://research.rug.nl/en/publications/b2680a5d-9ff0-4478-a3c2-9452afaf0fef

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The effects of an online decision aid to support the reproductive decision-making process of genetically at risk couples-A pilot study.

Autor: Severijns Y; Department of Health Promotion/CAPHRI, Maastricht University, Maastricht, The Netherlands.; GROW School for Oncology & Reproduction, Maastricht University Medical Centre+, Maastricht, The Netherlands., Heijmans MWF; Department of Health Promotion/CAPHRI, Maastricht University, Maastricht, The Netherlands., de Die-Smulders CEM; GROW School for Oncology & Reproduction, Maastricht University Medical Centre+, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Centre +, Maastricht, The Netherlands., Bijlsma EK; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands., Corsten-Janssen N; University of Groningen, University Medical Center Groningen Groningen, Department of Genetics, Groningen, The Netherlands., Joosten SJR; Department of Clinical Genetics, Radboudumc Nijmegen, Nijmegen, The Netherlands., van Kuijk SMJ; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+, Maastricht, The Netherlands., Lichtenbelt KD; Department of Genetics, Utrecht University Medical Center, Utrecht, The Netherlands., Ottenheim CPE; Department of Human Genetics, Amsterdam UMC, Amsterdam, The Netherlands., Stuurman KE; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Tan-Sindhunata GMB; Department of Human Genetics, Amsterdam UMC, Amsterdam, The Netherlands., de Vries H; Department of Health Promotion/CAPHRI, Maastricht University, Maastricht, The Netherlands., van Osch LADM; Department of Health Promotion/CAPHRI, Maastricht University, Maastricht, The Netherlands.; Department of Clinical Genetics, Maastricht University Medical Centre +, Maastricht, The Netherlands.

Publikováno v: Journal of genetic counseling [J Genet Couns] 2023 Feb; Vol. 32 (1), pp. 153-165. Date of Electronic Publication: 2022 Sep 03.

Preconception carrier screening for multiple disorders: evaluation of a screening offer in a Dutch founder population.

Autor: Mathijssen IB; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. i.b.mathijssen@amc.uva.nl., Holtkamp KCA; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands., Ottenheim CPE; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., van Eeten-Nijman JMC; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., Lakeman P; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., Meijers-Heijboer H; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands., van Maarle MC; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., Henneman L; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2018 Feb; Vol. 26 (2), pp. 166-175. Date of Electronic Publication: 2018 Jan 10.