NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.

Autor: Gleixner AM; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA., Verdone BM; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA., Otte CG; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA.; Physician Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Anderson EN; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Ramesh N; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA., Shapiro OR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA., Gale JR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA., Mauna JC; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA., Mann JR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA.; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA., Copley KE; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA., Daley EL; The Ken & Ruth Davee Department of Neurology, Northwestern University of Feinberg School of Medicine, Chicago, IL, USA., Ortega JA; The Ken & Ruth Davee Department of Neurology, Northwestern University of Feinberg School of Medicine, Chicago, IL, USA., Cicardi ME; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA., Kiskinis E; The Ken & Ruth Davee Department of Neurology, Northwestern University of Feinberg School of Medicine, Chicago, IL, USA.; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Kofler J; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA.; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Pandey UB; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA., Trotti D; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA., Donnelly CJ; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. cjdon25@pitt.edu.; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA. cjdon25@pitt.edu.; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA. cjdon25@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 13; Vol. 13 (1), pp. 3380. Date of Electronic Publication: 2022 Jun 13.

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies.

Autor: Berson A; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Goodman LD; Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Sartoris AN; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Otte CG; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Aykit JA; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lee VM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Bonini NM; Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA. nbonini@sas.upenn.edu.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Apr 29; Vol. 7 (1), pp. 65. Date of Electronic Publication: 2019 Apr 29.