Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ottavia Cecchetti"'
Autor:
Giacomo Paonessa, Giulia Siciliano, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.
Externí odkaz:
https://doaj.org/article/59fe7c35684348d7a872e3a5b86d2bef
Autor:
Licia Tomei, Antonino Missineo, Ottavia Cecchetti, Pier Giorgio Pacifici, Alberto Bresciani, Steven Rodems
Publikováno v:
SLAS Discovery. 23:941-950
Glycosylation is a key posttranslational modification that tags protein to membranes, organelles, secretory pathways, and degradation. Aberrant protein glycosylation is present both in acquired diseases, such as cancer and neurodegeneration, and in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3523fd964e83b17a675830bbc4c46444
https://doi.org/10.1177/2472555218782625
https://doi.org/10.1177/2472555218782625
Autor:
Nadia Gennari, Emanuela Nizi, Steven J. Harper, Savina Malancona, Sergio Altamura, Edith Monteagudo, David Roberts, Ilaria Biancofiore, Paul Willis, Maria Vittoria Orsale, Ottavia Cecchetti, Antonella Cellucci, Ralph Laufer, Rita Graziani, Alberto Bresciani, Simona Ponzi, Jesus Maria Ontoria Ontoria, Maria Veneziano, Annalise Di Marco, Giacomo Paonessa, Vincenzo Summa, Federica Ferrigno
Publikováno v:
ACS medicinal chemistry letters. 7(5)
The identification of a new series of P. falciparum growth inhibitors is described. Starting from a series of known human class I HDAC inhibitors a SAR exploration based on growth inhibitory activity in parasite and human cells-based assays led to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd9996399049eb56ee09a08a1c03acc
https://pubmed.ncbi.nlm.nih.gov/27190592
https://pubmed.ncbi.nlm.nih.gov/27190592
Autor:
Christian Steinkühler, Fabrizio Fiore, Olaf Kinzel, Barbara Attenni, Sergio Serafini, Giovanna Pescatore, Ottavia Cecchetti, Carsten Schultz-Fademrecht, Massimiliano Fonsi, Michael Rowley, Philip Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5528-5532
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7255cd3852dc10a6876068326211ba0e
https://doi.org/10.1016/j.bmcl.2008.09.003
https://doi.org/10.1016/j.bmcl.2008.09.003
Autor:
Jesus Maria Ontoria Ontoria, Michael Rowley, Ottavia Cecchetti, Matthew J. Bottomley, Federica Ferrigno, Rita Scarpelli, Christian Steinkühler, Andrea Carfi, Paola Lo Surdo, Carsten Schultz-Fademrecht, Philip Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3456-3461
The identification of class II HDAC inhibitors has been hampered by lack of efficient enzyme assays, in the preceding paper two assays have been developed to improve the efficiency of these enzymes: mutating an active site histidine to tyrosine, or b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c66929abcff6708a7312053c784c5c9
https://doi.org/10.1016/j.bmcl.2008.02.026
https://doi.org/10.1016/j.bmcl.2008.02.026
Autor:
Christian Steinkühler, Maria Vittoria Orsale, Michael Rowley, Sergio Altamura, Philip Jones, Danila Branca, Ester Muraglia, Ottavia Cecchetti, Maria Cecilia Palumbi, Rita Scarpelli, Federica Ferrigno
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
Trifluoroacetylthiophene carboxamides have recently been reported to be class II HDAC inhibitors, with moderate selectivity. Exploration of replacements for the carboxamide with bioisosteric pentatomic heteroaromatic like 1,3,4-oxadiazoles, 1,2,4-oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f718e2aaa967ba3002bc811a738fa134
https://pubmed.ncbi.nlm.nih.gov/18930398
https://pubmed.ncbi.nlm.nih.gov/18930398
Autor:
Marco Mattu, Ottavia Cecchetti, Andrea Carfi, Raffaele De Francesco, Christian Steinkühler, Paolo Di Giovine, Gaetano Barbato, Sergio Altamura
Publikováno v:
Analytical biochemistry. 377(2)
Histone deacetylase 4 (HDAC4) is a histone deacetylase profoundly involved in cell differentiation and in the pathogenesis of cancer. The histone deacetylase inhibitors are a new, promising class of anticancer agents. The screening of molecular inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897ee4ac4a5d9828a4c7c58a200eb343
https://pubmed.ncbi.nlm.nih.gov/18381195
https://pubmed.ncbi.nlm.nih.gov/18381195
Autor:
Peter T. Meinke, Paola Gallinari, Philip Jones, Raffaele Ingenito, Prasun K. Chakravarty, Sergio Serafini, Michael Rowley, Sergio Altamura, Rita Scarpelli, Raffaele De Francesco, Christian Steinkühler, Alessia Petrocchi, Ottavia Cecchetti
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in clinical trials. A structurally novel series of HDAC inhibitors based on the natural cyclic tetrapeptide Api
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e91256d53be31c4e1fb9e0e5594a3b
https://pubmed.ncbi.nlm.nih.gov/16987657
https://pubmed.ncbi.nlm.nih.gov/16987657
Autor:
Margherita Verani, Olaf Riess, Alberto Bresciani, Paola Martufi, Gerardo Biella, Paul Saftig, Elena Vezzoli, Francesca Talpo, Giulio Sancini, Ottavia Cecchetti, Paola Conforti, Andrea Falqui, Pia Rivetti di Val Cervo, Elisa Sogne, Lisa Seipold, Hoa Nguyen, Chiara Zuccato, Dario Besusso, Elena Cattaneo, Lara Petricca, Ilaria Caron, Andrea Caricasole, Elisa Battaglia
Publikováno v:
Journal of Clinical Investigation
A disintegrine and metalloproteinase 10 (ADAM10) is implicated in synaptic function through its interaction with postsynaptic receptors and adhesion molecules. Here, we report that levels of active ADAM10 are increased in Huntington's disease (HD) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42e3c790d5a18bb3e6bd76d36c0d7f6