Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Ottavia Spiga"'
Publikováno v:
Applied Sciences, Vol 14, Iss 20, p 9305 (2024)
Integrating Artificial Intelligence (AI) into Precision Medicine (PM) is redefining healthcare, enabling personalized treatments tailored to individual patients based on their genetic code, environment, and lifestyle. AI’s ability to analyze vast a
Externí odkaz:
https://doaj.org/article/f1e848541cf347fbb5e4c4e1272c01ff
Autor:
Luisa Frusciante, Michela Geminiani, Behnaz Shabab, Tommaso Olmastroni, Giorgia Scavello, Martina Rossi, Pierfrancesco Mastroeni, Collins Nyaberi Nyong’a, Laura Salvini, Stefania Lamponi, Maria Laura Parisi, Adalgisa Sinicropi, Lorenzo Costa, Ottavia Spiga, Alfonso Trezza, Annalisa Santucci
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1082 (2024)
Repurposing saffron (Crocus sativus) waste presents a sustainable strategy for generating high-value products within the bioeconomy framework. Typically, flower components are discarded after stigma harvest, resulting in significant waste—350 kg of
Externí odkaz:
https://doaj.org/article/c6a7757892804a389f7520921b935cfb
Autor:
Luisa Frusciante, Michela Geminiani, Tommaso Olmastroni, Pierfrancesco Mastroeni, Alfonso Trezza, Laura Salvini, Stefania Lamponi, Ottavia Spiga, Annalisa Santucci
Publikováno v:
Life, Vol 14, Iss 6, p 763 (2024)
The concept of a “circular bioeconomy” holds great promise for the health, cosmetic, and nutrition sectors by re-using Castanea sativa (Mill.) by-products. This sustainable resource is rich in bioactive secondary metabolites with antioxidant and
Externí odkaz:
https://doaj.org/article/83b73a78596b4002a39f7a2f0b53f77f
Autor:
Luisa Frusciante, Michela Geminiani, Alfonso Trezza, Tommaso Olmastroni, Pierfrancesco Mastroeni, Laura Salvini, Stefania Lamponi, Andrea Bernini, Daniela Grasso, Elena Dreassi, Ottavia Spiga, Annalisa Santucci
Publikováno v:
Marine Drugs, Vol 22, Iss 5, p 226 (2024)
Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest,
Externí odkaz:
https://doaj.org/article/2b341c8733dd4dcb82e29a840502a53a
Autor:
Malancha Karmakar, Vittoria Cicaloni, Carlos H.M. Rodrigues, Ottavia Spiga, Annalisa Santucci, David B. Ascher
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 271-277 (2022)
Alkaptonuria (AKU), a rare genetic disorder, is characterized by the accumulation of homogentisic acid (HGA) in the body. Affected individuals lack functional levels of an enzyme required to breakdown HGA. Mutations in the homogentisate 1,2-dioxygena
Externí odkaz:
https://doaj.org/article/09d4b2fbbc3e4c9c8c87bcee86a8dfe2
Autor:
Anna Visibelli, Luana Peruzzi, Paolo Poli, Antonella Scocca, Simona Carnevale, Ottavia Spiga, Annalisa Santucci
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1776 (2023)
Conventional therapy options for chronic pain are still insufficient and patients most frequently request alternative medical treatments, such as medical cannabis. Although clinical evidence supports the use of cannabis for pain, very little is known
Externí odkaz:
https://doaj.org/article/cf71429368c346f7a94e12e834d4c498
Autor:
Vittoria Cicaloni, Malancha Karmakar, Luisa Frusciante, Francesco Pettini, Anna Visibelli, Maurizio Orlandini, Federico Galvagni, Maurizio Mongiat, Michael Silk, Federica Nardi, David Ascher, Annalisa Santucci, Ottavia Spiga
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
The transmembrane glycoprotein CD93 has been identified as a potential new target to inhibit tumor angiogenesis. Recently, Multimerin-2 (MMRN2), a pan-endothelial extracellular matrix protein, has been identified as a ligand for CD93, but the interac
Externí odkaz:
https://doaj.org/article/06e83d3eadc84805a034ceb8e0e899cd
Autor:
Ottavia Spiga, Vittoria Cicaloni, Cosimo Fiorini, Alfonso Trezza, Anna Visibelli, Lia Millucci, Giulia Bernardini, Andrea Bernini, Barbara Marzocchi, Daniela Braconi, Filippo Prischi, Annalisa Santucci
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Background Alkaptonuria (AKU) is an ultra-rare autosomal recessive disease caused by a mutation in the homogentisate 1,2-dioxygenase (HGD) gene. One of the main obstacles in studying AKU, and other ultra-rare diseases, is the lack of a stand
Externí odkaz:
https://doaj.org/article/7e00aa955b77490f827561462633086f
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 887 (2023)
Emerging machine learning (ML) technologies have the potential to significantly improve the research and treatment of rare diseases, which constitute a vast set of diseases that affect a small proportion of the total population. Artificial Intelligen
Externí odkaz:
https://doaj.org/article/49579bb0b8f344f384a06676cd8800b6
Autor:
Daniela Braconi, Michela Geminiani, Eftychia Eirini Psarelli, Daniela Giustarini, Barbara Marzocchi, Ranieri Rossi, Giulia Bernardini, Ottavia Spiga, James A. Gallagher, Kim-Hanh Le Quan Sang, Jean-Baptiste Arnoux, Richard Imrich, Mohammed S. Al-Sbou, Matthew Gornall, Richard Jackson, Lakshminarayan R. Ranganath, Annalisa Santucci
Publikováno v:
Cells, Vol 11, Iss 22, p 3668 (2022)
Nitisinone (NTBC) was recently approved to treat alkaptonuria (AKU), but there is no information on its impact on oxidative stress and inflammation, which are observed in AKU. Therefore, serum samples collected during the clinical studies SONIA1 (40
Externí odkaz:
https://doaj.org/article/dfa79fb8afc24bcd809e1bad25c7ce7f