Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP142) administered intramuscularly with adjuvant system AS01

Autor: Otsyula Nekoye, Angov Evelina, Bergmann-Leitner Elke, Koech Margaret, Khan Farhat, Bennett Jason, Otieno Lucas, Cummings James, Andagalu Ben, Tosh Donna, Waitumbi John, Richie Nancy, Shi Meng, Miller Lori, Otieno Walter, Otieno Godfrey Allan, Ware Lisa, House Brent, Godeaux Olivier, Dubois Marie-Claude, Ogutu Bernhards, Ballou W Ripley, Soisson Lorraine, Diggs Carter, Cohen Joe, Polhemus Mark, Heppner D Gray, Ockenhouse Christian F, Spring Michele D

Publikováno v: Malaria Journal, Vol 12, Iss 1, p 29 (2013)

Abstract Background The development of an asexual blood stage vaccine against Plasmodium falciparum malaria based on the major merozoite surface protein-1 (MSP1) antigen is founded on the protective efficacy observed in preclinical studies and induct

Externí odkaz: https://doaj.org/article/6ee036a387234e1aa41bb45efe455f9b

Safety and immunogenicity of RTS,S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial

Autor: Otieno, Lucas, Oneko, Martina, Otieno, Walter, Abuodha, Joseph, Owino, Emmanuel, Odero, Chris, Mendoza, Yolanda Guerra, Andagalu, Ben, Awino, Norbert, Ivinson, Karen, Heerwegh, Dirk, Otsyula, Nekoye, Oziemkowska, Maria, Usuf, Effua Abigail, Otieno, Allan, Otieno, Kephas, Leboulleux, Didier, Leach, Amanda, Oyieko, Janet, Slutsker, Laurence, Lievens, Marc, Cowden, Jessica, Lapierre, Didier, Kariuki, Simon, Ogutu, Bernhards, Vekemans, Johan, Hamel, Mary J

Publikováno v: In The Lancet Infectious Diseases October 2016 16(10):1134-1144

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP142) administered intramuscularly with adjuvant system AS01.

Autor: Otsyula, Nekoye¹, Angov, Evelina², Bergmann-Leitner, Elke², Koech, Margaret¹, Khan, Farhat², Bennett, Jason², Otieno, Lucas¹, Cummings, James², Andagalu, Ben¹, Tosh, Donna², Waitumbi, John¹, Richie, Nancy², Shi, Meng², Miller, Lori², Otieno, Walter¹, Otieno, Godfrey Allan¹, Ware, Lisa², House, Brent³, Godeaux, Olivier³, Dubois, Marie-Claude³

Publikováno v: Malaria Journal. 2013, Vol. 12 Issue 1, p1-12. 12p. 2 Diagrams, 3 Charts, 4 Graphs.

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

Autor: Jahit Sacarlal, Agnes Akoth Onyango, Jackton Omoto, Portia Kamthunzi, Norbert Awino, Samuel Ayamba, Yolanda Guerra, Tisungane Mvalo, Diana Quelhas, Daniel Ansong, Didier Leboulleux, Béatrice Peggy Abossolo, Halidou Tinto, Dalitso Nyakuipa, Tsiri Agbenyega, Victorine Owira, Roma Chilengi, Kingsley Kayan, David Sambian, Terrell Carter, Ali Ali, Martha M. Lemnge, Cornelia Conzelmann, Seth Owusu-Agyei, Quique Bassat, Jean-Bosco Ouédraogo, William Kabore, José Francisco Fernandes, Chris Drakeley, Peter G. Kremsner, Afiya Radford, Saadou Issifou, Philip Bejon, Umberto D'Alessandro, Christian Loucq, Chris Odero, Francisca Machera, Pedro L. Alonso, Ali Mtoro, Theresa Rettig, John Lusingu, Albans Msika, Kwaku Poku Asante, Brian Greenwood, Alex Agyekum, George Adjei, Ruth Wasuna, Innocent Valea, Ali Hamad, Irving F. Hoffman, Rose Minja, Nelecy Chome, John Williamson, Charity Maingi, Salim Abdulla, Omar Juma, Amanda J. Leach, Stacey M. O. Gondi, W. Ripley Ballou, Mwanajaa Shomari, Johan Vekemans, Opokua Ofori-Anyinam, Hermann Sorgho, Samwel Gesase, Myriam Bruls, Allan Otieno, Barbara Gaelle Nfono Ondo Methogo, Kephas Otieno, David Dosoo, Benjamin Mordmüller, Walter Otieno, John J. Aponte, Yannick Doucka, Bertrand Lell, Didier Lapierre, Joe Cohen, Selidji T Agnandji, Coline Mahende, Alwisa Urassa, Lucas Otieno, Sofia Mandjate, David B. Jones, Samuel Adjei, Mary J. Hamel, Martina Oneko, Bernhards Ogutu, Hassan Kilavo, Marla Sillman, Isaac Asante, Ruth Owusu-Ofori, Preeti Vansadia, Laurence Slutsker, Sayouba Ouedraogo, John Bawa, Christine Kerubo, Omari Abdul, Pedro Aide, Justice Sylverken, Marcel Tanner, Barbara Savarese, David Schellenberg, Marc Christian Tahita, Norbert Peshu, Yara Sandrine, Owusu Boahen, Ruthendo Nkomo, Benjamin Tsofa, Kayla F. Laserson, Patricia Njuguna, Pauline Akoo, Joseph Chintedza, Grace Mwangoka, Miguel A. Lanaspa, Robert T. Guiguemdé, Erik Jongert, Allan Jumbe, Larko Owusu, Thor G. Theander, Alma Sykes, Francis Martinson, Edwin Liheluka, Eusebio Macete, Kingsley Osei-Kwakye, Marc Lievens, Saumu Ahmed, Nahya Salim, Otsyula Nekoye, Arlindo Nhamuave, Kafuruki Shubis, Kevin Marsh, Ally Olotu, Trudie Lang, Harry Owusu Boateng, Anangisye Malabeja, Arnaud Flamen, Simon Kariuki, Solange Soulanoudjingar, Jesse Gitaka, Vincent Muturi-Kioi, Daniel Chandramohan

Publikováno v: New England Journal of Medicine. 365:1863-1875

BACKGROUND An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries. METHODS From March 2009 through January 2011, we enrolled 15,460 children in two ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c16dced5eb2fd8989f7492b258232d8
https://doi.org/10.1056/nejmoa1102287

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

Autor: RTS,S Clinical Trials Partnership, Agnandji, Selidji Todagbe, Lell, Bertrand, Fernandes, José Francisco, Abossolo, Béatrice Peggy, Methogo, Barbara Gaelle Nfono Ondo, Kabwende, Anita Lumeka, Adegnika, Ayola Akim, Mordmüller, Benjamin, Issifou, Saadou, Kremsner, Peter Gottfried, Sacarlal, Jahit, Aide, Pedro, Lanaspa, Miguel, Aponte, John J, Machevo, Sonia, Acacio, Sozinho, Bulo, Helder, Sigauque, Betuel, Macete, Eusébio, Alonso, Pedro, Abdulla, Salim, Salim, Nahya, Minja, Rose, Mpina, Maxmillian, Ahmed, Saumu, Ali, Ali Mohammed, Mtoro, Ali Takadir, Hamad, Ali Said, Mutani, Paul, Tanner, Marcel, Tinto, Halidou, D'Alessandro, Umberto, Sorgho, Hermann, Valea, Innocent, Bihoun, Biébo, Guiraud, Issa, Kaboré, Berenger, Sombié, Olivier, Guiguemdé, Robert Tinga, Ouédraogo, Jean Bosco, Hamel, Mary J, Kariuki, Simon, Oneko, Martina, Odero, Chris, Otieno, Kephas, Awino, Norbert, McMorrow, Meredith, Muturi-Kioi, Vincent, Laserson, Kayla F, Slutsker, Laurence, Otieno, Walter, Otieno, Lucas, Otsyula, Nekoye, Gondi, Stacey, Otieno, Allan, Owira, Victorine, Oguk, Esther, Odongo, George, Woods, Jon Ben, Ogutu, Bernhards, Njuguna, Patricia, Chilengi, Roma, Akoo, Pauline, Kerubo, Christine, Maingi, Charity, Lang, Trudie, Olotu, Ally, Bejon, Philip, Marsh, Kevin, Mwambingu, Gabriel, Owusu-Agyei, Seth, Asante, Kwaku Poku, Osei-Kwakye, Kingsley, Boahen, Owusu, Dosoo, David, Asante, Isaac, Adjei, George, Kwara, Evans, Chandramohan, Daniel, Greenwood, Brian, Lusingu, John, Gesase, Samwel, Malabeja, Anangisye, Abdul, Omari, Mahende, Coline, Liheluka, Edwin, Malle, Lincoln, Lemnge, Martha, Theander, Thor G, Drakeley, Chris, Ansong, Daniel, Agbenyega, Tsiri, Adjei, Samuel, Boateng, Harry Owusu, Rettig, Theresa, Bawa, John, Sylverken, Justice, Sambian, David, Sarfo, Anima, Agyekum, Alex, Martinson, Francis, Hoffman, Irving, Mvalo, Tisungane, Kamthunzi, Portia, Nkomo, Rutendo, Tembo, Tapiwa, Tegha, Gerald, Tsidya, Mercy, Kilembe, Jane, Chawinga, Chimwemwe, Ballou, W Ripley, Cohen, Joe, Guerra, Yolanda, Jongert, Erik, Lapierre, Didier, Leach, Amanda, Lievens, Marc, Ofori-Anyinam, Opokua, Olivier, Aurélie, Vekemans, Johan, Carter, Terrell, Kaslow, David, Leboulleux, Didier, Loucq, Christian, Radford, Afiya, Savarese, Barbara, Schellenberg, David, Sillman, Marla, Vansadia, Preeti

BACKGROUND: The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants 6 to 12 weeks of age recruited for the sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::627444d217862e9c4174a586ebbeb0b8
https://researchonline.lshtm.ac.uk/id/eprint/427472/1/nejmoa1208394.pdf