Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Otová B"'
Autor:
Vlasta Němcová, Pavel Soucek, Ivan Gut, Jiří Hrdý, Otová B, Radka Vaclavikova, Stanislav Horský, Jana Vobořilová, Ilaria Zanardi, Iwao Ojima, Marie Ehrlichová, Jan Kovář
Publikováno v:
Investigational New Drugs. 30:991-1002
The study investigated possible mechanisms by which second-generation taxanes, established as significantly more effective than paclitaxel in vitro, suppress a rat lymphoma model in vivo. The studied mechanisms included taxane pharmacokinetics, expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28226834d863234d22cc33d8cf95b525
https://doi.org/10.1007/s10637-011-9654-0
https://doi.org/10.1007/s10637-011-9654-0
Publikováno v:
Biochemical Pharmacology. 69:1517-1521
A series of thymine phosphonomethoxyalkyl derivatives were evaluated for their ability to inhibit thymidine phosphorylase (dThdPase) purified from rat spontaneous T-cell lymphoma. A kinetic study of thymidine phosphorolysis catalyzed by dThdPase was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef9d43add4020cae0ed729654b8cf44
https://doi.org/10.1016/j.bcp.2005.03.003
https://doi.org/10.1016/j.bcp.2005.03.003
Publikováno v:
Biochemical Pharmacology. 58:487-492
The diphosphoryl derivative of the acyclic nucleotide phosphonate analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), found previously to weakly inhibit DNA pol δ/proliferating cell nuclear antigen, was studied as a substrate for pol α, δ, e, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e984e1f1f18d5b233a3b048a809d51
https://doi.org/10.1016/s0006-2952(99)00118-5
https://doi.org/10.1016/s0006-2952(99)00118-5
Publikováno v:
Collection of Czechoslovak Chemical Communications. 63:723-731
Using a simple isolation procedure and selective assay for the determination of enzyme activity the nonproteolyzed and proteolyzed form of DNA-polymerase ε (pol ε and pol ε*) from the lymphoma of Sprague-Dawley inbred rats were purified. Nonproteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e3a94ba1f2c8ab05880adae9eb99b96
https://doi.org/10.1135/cccc19980723
https://doi.org/10.1135/cccc19980723
Publikováno v:
Collection of Czechoslovak Chemical Communications. 60:1555-1572
Using a single isolation procedure and selective assays for the determination of enzyme activity, highly purified DNA-polymerases α, δ and ε were isolated from the lymphoma of Sprague-Dawley inbred rats. For pol α the subunit composition was 170,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d3a1a786fc77ed4eb3a4287e76798b
https://doi.org/10.1135/cccc19951555
https://doi.org/10.1135/cccc19951555
Autor:
Jozef Madzo, Julia Starkova, Otová B, Ondrej Hrusak, Marketa Kalinova, Ondrej Krejci, Jan Trka
Publikováno v:
Leukemia. 18(3)
L-Asparaginase is a standard component in chemotherapy of childhood acute lymphoblastic leukaemia (ALL). Leukaemic cells carrying TEL/AML1 fusion gene are more sensitive to treatment with L-asparaginase compared to other subtypes of ALL. We demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb96d70d8b2c175a10f648fdb2690b1
https://pubmed.ncbi.nlm.nih.gov/15526023
https://pubmed.ncbi.nlm.nih.gov/15526023
Autor:
Jan Zuna, Kateřina Mužíková, Jan Starý, Ondřej Hrušák, Otová B, Ondřej Krejčí, Marketa Kalinova, Jan Trka, Jozef Madžo
Publikováno v:
Cancer. 97(1)
BACKGROUND The translocation t(12;21)(p13;q22), which produces the TEL/AML1 fusion gene, is the most frequent chromosomal abnormality in patients with childhood acute lymphoblastic leukemia (ALL) and generally is associated with a favorable prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39185c311921ef2a76be0c41d7875b5b
https://pubmed.ncbi.nlm.nih.gov/12491511
https://pubmed.ncbi.nlm.nih.gov/12491511
Tenofovir {9-R-[2-(phosphonomethoxy)propyl]adenine;PMPA} is an acyclic nucleoside phosphonate (ANP) (12, 14) whose lipophilic prodrug, tenofovir disoproxil fumarate (Viread), was recently approved (18) for the treatment of human immunodeficiency viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297902847bfa70add7a4ecead11eef6a
https://europepmc.org/articles/PMC127178/
https://europepmc.org/articles/PMC127178/
Publikováno v:
Transplantation proceedings. 31(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3749a214a92e38ee1a5c6fe56b5abde7
https://pubmed.ncbi.nlm.nih.gov/10331023
https://pubmed.ncbi.nlm.nih.gov/10331023
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d376244ead56b204c8d9d47afe28600d
https://doi.org/10.1135/css199902289
https://doi.org/10.1135/css199902289