Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.

Autor: Arora R; Novartis Institute for Biomedical Research, Cambridge, Massachusetts, USA., Liew CW; NTU Institute of Structural Biology, Nanyang Technological University, Singapore., Soh TS; Novartis Institute for Tropical Diseases, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore., Otoo DA; Novartis Institute for Tropical Diseases, Singapore., Seh CC; Novartis Institute for Tropical Diseases, Singapore., Yue K; Novartis Institute for Biomedical Research, Cambridge, Massachusetts, USA., Nilar S; Novartis Institute for Tropical Diseases, Singapore., Wang G; Novartis Institute for Tropical Diseases, Singapore., Yokokawa F; Novartis Institute for Tropical Diseases, Singapore., Noble CG; Novartis Institute for Tropical Diseases, Singapore., Chen YL; Novartis Institute for Tropical Diseases, Singapore., Shi PY; Novartis Institute for Tropical Diseases, Singapore., Lescar J; NTU Institute of Structural Biology, Nanyang Technological University, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore., Smith TM; Novartis Institute for Biomedical Research, Cambridge, Massachusetts, USA., Benson TE; Novartis Institute for Biomedical Research, Cambridge, Massachusetts, USA timothy.benson@novartis.com siewpheng-lim@denka.com.sg., Lim SP; Novartis Institute for Tropical Diseases, Singapore timothy.benson@novartis.com siewpheng-lim@denka.com.sg.

Publikováno v: Journal of virology [J Virol] 2020 Nov 23; Vol. 94 (24). Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).