Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Otoniel Martinez-Maza"'
Autor:
Joshua Zhang, Mary E. Sehl, Roger Shih, Elizabeth Crabb Breen, Fengxue Li, Ake T. Lu, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Steve Horvath, Beth D. Jamieson
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Introduction: Highly active antiretroviral therapy (HAART) helps improve some measures of accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the epigenome is not fully understood.Methods: In this study, we analy
Externí odkaz:
https://doaj.org/article/b3905060df8f42c5b15b836f9f6b4669
Autor:
Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
IntroductionPersons living with HIV (PLWH) experience the early onset of age-related illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression with highly active antiretroviral therapy (HAART). HIV infection is assoc
Externí odkaz:
https://doaj.org/article/b9807aa06bea4118a72dfc77fba1c39e
Autor:
Mengyao Shi, Xiaoyu Zong, Jinhee Hur, Brenda M. Birmann, Otoniel Martinez-Maza, Marta Epeldegui, Andrew T. Chan, Edward L. Giovannucci, Yin Cao
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104566- (2023)
Summary: Background: Gut microbial dysbiosis contributes to colorectal cancer (CRC) pathogenesis, possibly mediated in part by increased intestinal permeability to endotoxin lipopolysaccharide (LPS), microbial translocation, and subsequent endotoxemi
Externí odkaz:
https://doaj.org/article/e9c3f15fadf84ca8a989ef59f19a7855
Autor:
Najib Aziz, Roger Shih, Nicole Alexopoulos, Beth D Jamieson, Matthew J Mimiaga, Otoniel Martinez-Maza, Roger Detels
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0290702 (2023)
IntroductionInterleukin 6 (IL-6) activates cells through its unique heterodimeric signaling complex of IL-6 receptor (IL6R) subunit and interleukin 6 signal transducer β-subunit glycoprotein 130 (gp130). The objective of this study was to investigat
Externí odkaz:
https://doaj.org/article/3f7aaca1d9bf4a749f98b734063aad07
Autor:
Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Larry Chen, Ruibin Wang, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Epigenetic aging is accelerated in tissues of persons living with HIV (PLWH) and may underlie the early onset of age-related illnesses. This study examines the rate-of-change in epigenetic age in PLWH following HIV infection but before HA
Externí odkaz:
https://doaj.org/article/3899d6314e1a4354971179465b206a49
Autor:
Mary E. Sehl, Tammy M. Rickabaugh, Roger Shih, Otoniel Martinez-Maza, Steve Horvath, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Pathogens and Immunity, Vol 5, Iss 1, Pp 291-311 (2020)
Background: HIV-1 infection is associated with acceleration of age-related methylation patterns in peripheral blood and brain of infected individuals although the relative contributions of HIV-1 infection versus its treatment to the observed accelera
Externí odkaz:
https://doaj.org/article/bca39c858722418d9a71064396d1d39e
Autor:
Bradley Salvatore, Rachel S. Resop, Brent R. Gordon, Marta Epeldegui, Otoniel Martinez-Maza, Begoña Comin-Anduix, Alex Lam, Ting-Ting Wu, Christel H. Uittenbogaart
Publikováno v:
Cells, Vol 12, Iss 2, p 296 (2023)
Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV persi
Externí odkaz:
https://doaj.org/article/0a257bd8f59e4d1b83a1124c06c76197
Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
Autor:
Jun Wang, David V. Conti, Marta Epeldegui, Miina Ollikainen, Rachel F. Tyndale, Amie Eunah Hwang, Larry Magpantay, Thomas McCulloch Mack, Otoniel Martinez-Maza, Jaakko Kaprio, Wendy Cozen
Publikováno v:
Cancers, Vol 13, Iss 21, p 5395 (2021)
Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Pre
Externí odkaz:
https://doaj.org/article/d39cf07847d14c51a74eed5b147fa4f7
Autor:
Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, Ren Sun
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Certain “protective” major histocompatibility complex class I (MHC-I) alleles, such as B*57 and B*27, are associated with long-term control of HIV-1 in vivo mediated by the CD8+ cytotoxic-T-lymphocyte (CTL) response. However, the mechani
Externí odkaz:
https://doaj.org/article/85c05c9d6e2845998b33493d2d33d8ed
Autor:
Yuan Lyu, Hussein Kaddour, Steven Kopcho, Tyler D. Panzner, Nadia Shouman, Eun-Young Kim, Jeremy Martinson, Heather McKay, Otoniel Martinez-Maza, Joseph B. Margolick, Jack T. Stapleton, Chioma M. Okeoma
Publikováno v:
Cells, Vol 8, Iss 9, p 1027 (2019)
Semen exosomes (SE) from HIV-uninfected (HIV−) individuals potently inhibit HIV infection in vitro. However, morphological changes in target cells in response to SE have not been characterized or have the effect of HIV infection or the use of illic
Externí odkaz:
https://doaj.org/article/986563cec5744f4ab6ed2494e52696fd