Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Otmar Huber"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
GDP-mannose pyrophosphorylase B (GMPPB) loss-of-function is associated with muscular dystrophy and variable additional neurological symptoms. GMPPB facilitates the catalytic conversion of mannose-1-phosphate and GTP to GDP-mannose, which serves as a
Externí odkaz:
https://doaj.org/article/06f33afb30504db6b876182ecef6a49e
Publikováno v:
Cells, Vol 12, Iss 3, p 353 (2023)
In previous studies, we have identified the tumor suppressor proteins Fhit (fragile histidine triad) and Nit1 (Nitrilase1) as interaction partners of β-catenin both acting as repressors of the canonical Wnt pathway. Interestingly, in D. melanogaster
Externí odkaz:
https://doaj.org/article/498036fb005444f38d828abb49681b6e
Publikováno v:
Cells, Vol 11, Iss 20, p 3296 (2022)
Tight junctions (TJs) regulate the transit of ions and molecules through the paracellular pathway in epithelial cells. Zonula occludens 2 (ZO-2) is a cytoplasmic TJ protein. Here, we studied the ubiquitination of hZO-2 employing mutants of SUMOylatio
Externí odkaz:
https://doaj.org/article/5312a3a51d7c479f9a1417501fbf8e9d
Autor:
Alexander Kaiser, Thomas Krüger, Gabriele Eiselt, Joachim Bechler, Olaf Kniemeyer, Otmar Huber, Martin Schmidt
Publikováno v:
Cells, Vol 9, Iss 2, p 427 (2020)
Paracrine interactions between malignant estrogen receptor positive (ER+) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs. In breast cancer, mainly the cAMP-responsive promoter I.3/II-reg
Externí odkaz:
https://doaj.org/article/a9d65e1320d5460e8952e3c083c19aec
Autor:
René Schiffner, Sabine Juliane Bischoff, Thomas Lehmann, Florian Rakers, Sven Rupprecht, Georg Matziolis, Harald Schubert, Matthias Schwab, Otmar Huber, Cornelius Lemke, Martin Schmidt
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196363 (2018)
While the cerebral autoregulation sufficiently protects subcortical brain regions during hypoxia or asphyxia, the cerebral cortex is not as adequately protected, which suggests that regulation of the cerebral blood flow (CBF) is area-specific. Hypoxi
Externí odkaz:
https://doaj.org/article/c67c69656b654a8fb78dc2e22fe7e69d
Publikováno v:
Cells, Vol 8, Iss 11, p 1320 (2019)
Glycation occurs as a non-enzymatic reaction between amino and thiol groups of proteins, lipids, and nucleotides with reducing sugars or α-dicarbonyl metabolites. The chemical reaction underlying is the Maillard reaction leading to the formation of
Externí odkaz:
https://doaj.org/article/15a10806fd384ab2a686d428253ab7b0
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 12, Pp 1421-1432 (2008)
Down-regulation of the KAI1 (CD82) metastasis suppressor is common in advanced human cancer, but underlying mechanism(s) regulating KAI1 expression are only now being elucidated. Recent data provide evidence that low levels of KAI1 mRNA in LNCaP cell
Externí odkaz:
https://doaj.org/article/7a6b1fa543c0476ba1aed7f43b94906d
Autor:
Chen, Yunxia Ma, Rumyana Marinkova, Miljana Nenkov, Lai Jin, Otmar Huber, Jürgen Sonnemann, Natália Peca, Nikolaus Gaßler, Yuan
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11031
Programmed death ligand 1 (PD-L1) strongly inhibits T cell activation, thereby aiding tumors in escaping the immune response. PD-L1 inhibitors have proven to be effective in the treatment of different types of cancer, including non-small cell lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6b49039a055c23cd481b8453c257de3e
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES. 1515(1)
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes phosphorylating phospholipids in the membrane, thereby, promoting the PI3K/AKT signaling cascade. PI3Ks are involved in a variety of fundamental cellular functions, including tumor necrosis f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bfca771a5db5b03012691580645166
https://pubmed.ncbi.nlm.nih.gov/35725890
https://pubmed.ncbi.nlm.nih.gov/35725890
Autor:
Yunxia, Ma, Rumyana, Marinkova, Miljana, Nenkov, Lai, Jin, Otmar, Huber, Jürgen, Sonnemann, Natália, Peca, Nikolaus, Gaßler, Yuan, Chen
Publikováno v:
International journal of molecular sciences. 23(19)
Programmed death ligand 1 (PD-L1) strongly inhibits T cell activation, thereby aiding tumors in escaping the immune response. PD-L1 inhibitors have proven to be effective in the treatment of different types of cancer, including non-small cell lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7bb5a16014cbee9463c71ba2d9de02b
https://pubmed.ncbi.nlm.nih.gov/36232331
https://pubmed.ncbi.nlm.nih.gov/36232331