Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Otmane Lamrabet"'
Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes
Autor:
Estelle Ifrid, Hajer Ouertatani-Sakouhi, Hiba Zein El Dine, Tania Jauslin, Gianpaolo Chiriano, Leonardo Scapozza, Otmane Lamrabet, Pierre Cosson
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/7b22041fc42148118fb914814017412d
Autor:
Romain Bodinier, Ayman Sabra, Jade Leiba, Anna Marchetti, Otmane Lamrabet, Imen Ayadi, Vedrana Filić, Takefumi Kawata, Igor Weber, Pierre Cosson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously un
Externí odkaz:
https://doaj.org/article/6eb249a6e9d147ecbc50769fc28a3d7f
Autor:
Cyril Guilhen, Wanessa C. Lima, Estelle Ifrid, Xenia Crespo-Yañez, Otmane Lamrabet, Pierre Cosson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Phagocytic cells ingest and destroy bacteria efficiently and in doing so ensure the defense of the human body against infections. Phagocytic Dictyostelium discoideum amoebae represent a powerful model system to study the intracellular mechanisms ensu
Externí odkaz:
https://doaj.org/article/1d7a376201ab44e283c57f459172e3eb
How Phagocytic Cells Kill Different Bacteria: a Quantitative Analysis Using Dictyostelium discoideum
Autor:
Tania Jauslin, Otmane Lamrabet, Xenia Crespo-Yañez, Anna Marchetti, Imen Ayadi, Estelle Ifrid, Cyril Guilhen, Matthias Leippe, Pierre Cosson
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Phagocytic cells ingest and kill bacteria, a process essential for the defense of the human body against infections. Many potential killing mechanisms have been identified in phagocytic cells, including free radicals, toxic ions, enzymes, and permeab
Externí odkaz:
https://doaj.org/article/7e785befb8954747a489cfda12ffd5c5
Autor:
Otmane Lamrabet, Astrid Melotti, Frédéric Burdet, Nabil Hanna, Jackie Perrin, Jahn Nitschke, Marco Pagni, Hubert Hilbi, Thierry Soldati, Pierre Cosson
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Dictyostelium discoideum amoebae feed by ingesting bacteria, then killing them in phagosomes. Ingestion and killing of different bacteria have been shown to rely on largely different molecular mechanisms. One would thus expect that D. discoideum adap
Externí odkaz:
https://doaj.org/article/fff77f7db321436a87f6ff4d8e1735f8
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT High-level resistance often evolves when populations of bacteria are exposed to antibiotics, by either mutations or horizontally acquired genes. There is also variation in the intrinsic resistance levels of different bacterial strains and sp
Externí odkaz:
https://doaj.org/article/fa8434345a574e8f8cf7ab7eb704f845
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34754 (2012)
Free-living protozoa allow horizontal gene transfer with and between the microorganisms that they host. They host mycobacteria for which the sources of transferred genes remain unknown. Using BLASTp, we searched within the genomes of 15 mycobacteria
Externí odkaz:
https://doaj.org/article/a1ffdc39a97e4fbebd12d0406dea9739
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29833 (2012)
BACKGROUND: Mycobacterium smegmatis is a rapidly-growing mycobacterium causing rare opportunistic infections in human patients. It is present in soil and water environments where free-living amoeba also reside, but data regarding M. smegmatis-amoeba
Externí odkaz:
https://doaj.org/article/4de5b570742f4b85ae71ccc544fbca57
Autor:
Xènia Crespo‐Yanez, Joseph Oddy, Otmane Lamrabet, Tania Jauslin, Anna Marchetti, Pierre Cosson
Publikováno v:
Molecular Microbiology. 119:74-85
Mammalian professional phagocytic cells ingest and kill invading microorganisms and prevent the development of bacterial infections. Our understanding of the sequence of events that results in bacterial killing and permeabilization in phagosomes is s
Autor:
Anna Marchetti, Romain Bodinier, Pierre Cosson, Otmane Lamrabet, Vedrana Filić, Imen Ayadi, Jade Leiba, Igor Weber, Takefumi Kawata, Ayman Sabra
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in cell and developmental biology
Frontiers in Cell and Developmental Biology
Frontiers in cell and developmental biology
Frontiers in Cell and Developmental Biology
LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously un