Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Otis Lyght"'
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 1, Pp 59-70 (2009)
Vascular dysfunction in response to reactive oxygen species (ROS) plays an important role in the development and progression of atherosclerotic lesions. In most cells, mitochondria are the major source of cellular ROS during aerobic respiration. Unde
Externí odkaz:
https://doaj.org/article/ccda75385d284271a5f32de01b307de1
Autor:
Kiefer W. Daniel, Sheila Collins, Barbara E. Corkey, Yushi Bai, Otis Lyght, Dianxin Liu, Jingbo Pi, Diane Edelstein, Michael Brownlee
Publikováno v:
Endocrinology. 150:3040-3048
Uncoupling protein (UCP) 2 is a widely expressed mitochondrial protein whose precise function is still unclear but has been linked to mitochondria-derived reactive oxygen species production. Thus, the chronic absence of UCP2 has the potential to prom
Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 1, Pp 59-70 (2009)
Vascular dysfunction in response to reactive oxygen species (ROS) plays an important role in the development and progression of atherosclerotic lesions. In most cells, mitochondria are the major source of cellular ROS during aerobic respiration. Unde
Autor:
Cynthia Shackelford, David Olson, Margarita M. Gruebbel, Catherine A. Picut, Otis Lyght, Ronald Herbert, Yvette Rebolloso, Kyathanahalli S. Janardhan, Natasha Clayton, Geoffrey Hurlburt
Publikováno v:
Toxicologic pathology. 43(5)
Methyl eugenol induces neuroendocrine (NE) cell hyperplasia and tumors in F344/N rat stomach. Detailed histopathological and immunohistochemical (IHC) characterization of these tumors has not been previously reported. The objective of this study was
Publikováno v:
Carcinogenesis. 16:77-82
Transforming growth factor alpha (TGF alpha) is a mitogenic growth factor for hepatocytes that may play a role in the development of liver cancer in rodents and humans. Epidermal growth factor receptor (EGFR) is the receptor for TGF alpha; its expres
Autor:
James C. Bonner, Otis Lyght, Jennifer L. Ingram, Jack A. Elias, James B. Mangum, Patty J. Lee, Aurita Antao-Menezes
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(6)
IL-13 is a key cytokine involved in airway remodeling in asthma. We previously reported that IL-13 stimulated the mitogenesis of lung fibroblasts via platelet-derived growth factor (PDGF)-AA. In this report, we show that IL-13 increases PDGF-A and PD
Autor:
Derek B. Janszen, Lilian Calderón-Garcidueñas, Anna Villarreal-Calderón, Antonio Rodriguez-Alcaraz, Kevin T. Morgan, Otis Lyght
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 46(2)
A wide range of chemicals, particulate matter, and gaseous air pollutants are present in urban atmospheres and may pose a significant health risk for human populations. Nasal passages are the first site of contact of the respiratory tract with the en
Publikováno v:
Carcinogenesis. 3:851-856
A number of model systems have been developed to study the initiating and promoting phases of neoplastic development in rats liver. Four of these protocols use diethylnitrosamine (DEN) initiation, but employ different methods of promotion. The presen
Publikováno v:
Toxicology and Applied Pharmacology. 96:367-379
Trichloroethylene (TCE), perchloroethylene (PER), and pentachloroethane (PENT) are used extensively as industrial solvents. These agents cause an increased incidence of renal tumors in male, but not female, rats. Male and female F-344 rats were gavag
Publikováno v:
Carcinogenesis. 4(8)
Technical grade dinitrotoluene (TDNT), composed principally of 2,4-DNT (76%) and 2,6-DNT (20%), is a potent hepatocarcinogen when fed to male F-344 rats for 1 year (100% incidence of hepatocellular carcinoma) while 2,4-DNT is only weakly hepatocarcin