Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone.

Autor: Choi EM; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: edward.choi@lshtm.ac.uk., Lacarra B; REACTing Unit, Inserm, Paris, France., Afolabi MO; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., Ale BM; Clinical Investigation Center-Clinical Epidemiology, University of Bordeaux, Inserm, Institut Bergonié, EUCLID/F-CRIN CIC-EC1401, Bordeaux, France., Baiden F; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., Bétard C; Clinical Investigation Center-Clinical Epidemiology, University of Bordeaux, Inserm, Institut Bergonié, EUCLID/F-CRIN CIC-EC1401, Bordeaux, France., Foster J; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., Hamzé B; Pôle Recherche Clinique, Inserm, Paris, France., Schwimmer C; Clinical Investigation Center-Clinical Epidemiology, University of Bordeaux, Inserm, Institut Bergonié, EUCLID/F-CRIN CIC-EC1401, Bordeaux, France; Department of Medical Information, Centre Hospitalier Universitaire (CHU) de Bordeaux, EUCLID/F-CRIN CIC-EC1401, Inserm, Institut Bergonié, Bordeaux, France., Manno D; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., D'Ortenzio E; ANRS, Maladies infectieuses émergentes, Inserm, Paris, France., Ishola D; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., Keita CM; Centre National de Formation et de Recherche en Santé Rurale de Mafèrinyah, Forécariah, Guinea., Keshinro B; Janssen Vaccines & Prevention, Leiden, Netherlands., Njie Y; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., van Dijck W; Janssen Research & Development, Beerse, Belgium., Gaddah A; Janssen Research & Development, Beerse, Belgium., Anumendem D; Janssen Research & Development, Beerse, Belgium., Lowe B; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., Vatrinet R; REACTing Unit, Inserm, Paris, France., Lawal BJ; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., Otieno GT; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC-Salone Project, Kambia, Sierra Leone., Samai M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Deen GF; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Swaray IB; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Kamara AB; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Kamara MM; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., Diagne MA; Laboratoire de Sociologie, Anthropologie et Psychologie Sociale, Department of Sociology, Université Cheikh Anta Diop de Dakar, Dakar, Senegal., Kowuor D; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK., McLean C; Janssen Vaccines & Prevention, Leiden, Netherlands., Leigh B; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Beavogui AH; Centre National de Formation et de Recherche en Santé Rurale de Mafèrinyah, Forécariah, Guinea., Leyssen M; Janssen Vaccines & Prevention, Leiden, Netherlands., Luhn K; Janssen Vaccines & Prevention, Leiden, Netherlands., Robinson C; Janssen Vaccines & Prevention, Leiden, Netherlands., Douoguih M; Janssen Vaccines & Prevention, Leiden, Netherlands., Greenwood B; Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK., Thiébaut R; Clinical Investigation Center-Clinical Epidemiology, University of Bordeaux, Inserm, Institut Bergonié, EUCLID/F-CRIN CIC-EC1401, Bordeaux, France; Department of Medical Information, Centre Hospitalier Universitaire (CHU) de Bordeaux, EUCLID/F-CRIN CIC-EC1401, Inserm, Institut Bergonié, Bordeaux, France., Watson-Jones D; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.

Publikováno v: The Lancet. Global health [Lancet Glob Health] 2023 Nov; Vol. 11 (11), pp. e1743-e1752.

Safety and immunogenicity of an Ad26.ZEBOV booster dose in children previously vaccinated with the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen: an open-label, non-randomised, phase 2 trial.

Autor: Manno D; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: daniela.manno@lshtm.ac.uk., Bangura A; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Baiden F; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Kamara AB; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Ayieko P; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania., Kallon J; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Foster J; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Conteh M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Connor NE; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Koroma B; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Njie Y; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Borboh P; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Keshinro B; Janssen Vaccines and Prevention, Leiden, Netherlands., Lawal BJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Kroma MT; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Otieno GT; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Deen AT; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Choi EM; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Balami AD; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Gaddah A; Janssen Research and Development, Beerse, Belgium., McLean C; Janssen Vaccines and Prevention, Leiden, Netherlands., Luhn K; Janssen Vaccines and Prevention, Leiden, Netherlands., Adetola HH; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia Town, Kambia District, Sierra Leone., Deen GF; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Samai M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Lowe B; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Robinson C; Janssen Vaccines and Prevention, Leiden, Netherlands., Leigh B; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Greenwood B; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Watson-Jones D; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2023 Mar; Vol. 23 (3), pp. 352-360. Date of Electronic Publication: 2022 Oct 20.

Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial.

Autor: Afolabi MO; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone. Electronic address: muhammed.afolabi@lshtm.ac.uk., Ishola D; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Manno D; London School of Hygiene & Tropical Medicine, London, UK., Keshinro B; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Bockstal V; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Rogers B; EBOVAC Project, Kambia, Kambia district, Sierra Leone; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Owusu-Kyei K; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Serry-Bangura A; EBOVAC Project, Kambia, Kambia district, Sierra Leone; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Swaray I; EBOVAC Project, Kambia, Kambia district, Sierra Leone; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Lowe B; London School of Hygiene & Tropical Medicine, London, UK; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Kowuor D; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Baiden F; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Mooney T; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Smout E; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Köhn B; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Otieno GT; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone., Jusu M; London School of Hygiene & Tropical Medicine, London, UK; EBOVAC Project, Kambia, Kambia district, Sierra Leone; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Foster J; London School of Hygiene & Tropical Medicine, London, UK., Samai M; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Deen GF; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Larson H; London School of Hygiene & Tropical Medicine, London, UK; Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA., Lees S; London School of Hygiene & Tropical Medicine, London, UK., Goldstein N; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Gallagher KE; London School of Hygiene & Tropical Medicine, London, UK., Gaddah A; Janssen Research & Development, Beerse, Belgium., Heerwegh D; Janssen Research & Development, Beerse, Belgium., Callendret B; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Luhn K; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Robinson C; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Greenwood B; London School of Hygiene & Tropical Medicine, London, UK., Leyssen M; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Douoguih M; Janssen Vaccines and Prevention BV, Leiden, Netherlands., Leigh B; College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone., Watson-Jones D; London School of Hygiene & Tropical Medicine, London, UK; Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2022 Jan; Vol. 22 (1), pp. 110-122. Date of Electronic Publication: 2021 Sep 13.