Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Othon L. Gervásio"'
Autor:
David G. Allen, Othon L. Gervásio, Bao-Ting Zhang, Diane Fatkin, Ella W. Yeung, Trent F. Reardon, Molly Vale, Nicholas P. Whitehead, Alexander Dietrich
Publikováno v:
Journal of Applied Physiology. 112:2077-2086
Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca2+ entry and activation of cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59fb3ad599e6d4d8ece70c602dc0c66
https://doi.org/10.1152/japplphysiol.00770.2011
https://doi.org/10.1152/japplphysiol.00770.2011
Publikováno v:
Journal of Cell Science. 124:3581-3590
Caveolae are invaginations of the plasma membrane that are formed by caveolins. Caveolar membranes are also enriched in cholesterol, glycosphingolipids and signaling enzymes such as Src kinase. Here we investigate the effect of cell stretch upon cave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19306423e9b17fd49756a9f7c75a300f
https://doi.org/10.1242/jcs.084376
https://doi.org/10.1242/jcs.084376
Autor:
Othon L. Gervásio, R. N. Cole, Stephen W. Reddel, Nazanin Ghazanfari, William D. Phillips, Shyuan T. Ngo
Publikováno v:
The Journal of Physiology. 588:3217-3229
The postsynaptic muscle-specific kinase (MuSK) coordinates formation of the neuromuscular junction (NMJ) during embryonic development. Here we have studied the effects of MuSK autoantibodies upon the NMJ in adult mice. Daily injections of IgG from fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f040abe1e272742bfc4daa996830dde
https://doi.org/10.1113/jphysiol.2010.190298
https://doi.org/10.1113/jphysiol.2010.190298
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 88:83-91
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by the absence of the cytoskeletal protein dystrophin. Experiments on the mdx mouse, a model of DMD, have shown that mdx muscles are particularly susceptible to stretch-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e7f89e1acbc0585429ae8fe4dd3e47
https://doi.org/10.1139/y09-058
https://doi.org/10.1139/y09-058
Autor:
Othon L. Gervásio, Shane T. Antao, Karen M. Cullen, James R. Bamburg, Ineka T. Whiteman, Paul K. Witting, Gilles J. Guillemin, Claire Goldsbury, Erica V. Jeong, Laurie S. Minamide
Publikováno v:
The Journal of Neuroscience. 29:12994-13005
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin–actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07fd67107f52d37a9d44c0e4ef647c9
https://doi.org/10.1523/jneurosci.3531-09.2009
https://doi.org/10.1523/jneurosci.3531-09.2009
Publikováno v:
Journal of Cell Science. 121:2246-2255
Transient receptor potential canonical 1 (TRPC1), a widely expressed calcium (Ca2+)-permeable channel, is potentially involved in the pathogenesis of Duchenne muscular dystrophy (DMD). Ca2+ influx through stretch-activated channels, possibly formed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189ca6742f01b5a7376ec492a26202c5
https://doi.org/10.1242/jcs.032003
https://doi.org/10.1242/jcs.032003
Publikováno v:
The Journal of Physiology. 586:2003-2014
Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by a mutation in the gene encoding dystrophin, a protein linking the cytoskeleton to the extracellular matrix. In this study we investigated whether the antioxidant N-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752d6c7e5d544bec093214c5fbe10fd5
https://doi.org/10.1113/jphysiol.2007.148338
https://doi.org/10.1113/jphysiol.2007.148338
Autor:
Gregory T. Kitten, Lorenza Machado de Souza Carvalhaes, Taina Pihlajaniemi, Cristina Guatimosim, Raija Sormunen, Othon L. Gervásio, Ritva Heljasvaara
Publikováno v:
Developmental Dynamics. 235:132-142
Type XVIII collagen is a multidomain protein that contains cleavable C-terminal NC1 and endostatin fragments, which have been shown to either induce or inhibit cell migration. Endostatin is being intensely studied because of its anti-angiogenic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d71da13982f7b4cfd1f94c9f077665
https://doi.org/10.1002/dvdy.20556
https://doi.org/10.1002/dvdy.20556
Autor:
Othon L. Gervásio, William D. Phillips
Publikováno v:
The Journal of Physiology. 562:673-685
The metabolic turnover of nicotinic ACh receptors (AChR) at the neuromuscular synapse is regulated over a tenfold range by innervation status, muscle electrical activity and neural agrin, but the downstream effector of such changes has not been defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::433327c63ae2465425012dca14b68470
https://doi.org/10.1113/jphysiol.2004.077685
https://doi.org/10.1113/jphysiol.2004.077685
Autor:
William D. Phillips, Othon L. Gervásio, Jennifer Brockhausen, R. N. Cole, Shyuan T. Ngo, Peter G. Noakes
Publikováno v:
Developmental neurobiology. 68(9)
Fluorescence resonance energy transfer (FRET) experiments at neuromuscular junctions in the mouse tibialis anterior muscle show that postsynaptic acetylcholine receptors (AChRs) become more tightly packed during the first month of postnatal developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f2a5788e920ecfce23b6e7b6a97d92
https://pubmed.ncbi.nlm.nih.gov/18506821
https://pubmed.ncbi.nlm.nih.gov/18506821