Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Otfried Strubelt"'
Publikováno v:
Toxicological Sciences. 49:133-142
We investigated the acute toxic and metabolic effects of 23-aliphatic alcohols (16 saturated and 7 unsaturated) in the isolated perfused rat liver at a concentration of 65.1 mmol/l (approximately 0.3% ethanol). The capacity of the straight chain prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6133ae543a0600aee688ac8a8c90f7c
https://doi.org/10.1093/toxsci/49.1.133
https://doi.org/10.1093/toxsci/49.1.133
Influence of glycine on the damage induced in isolated perfused rat liver by five hepatotoxic agents
Publikováno v:
Toxicology. 128:63-72
Livers of fasted rats were perfused over 120 min in a recirculating hemoglobin-free system. Hepatotoxic injury induced by the addition of 1-butanol (130.2 mmol/l), CdCl 2 (0.1 mmol/l), CuCl 2 (0.03 mmol/l), Na 3 VO 4 (2 mmol/l) or t -butylhydroperoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1622333cd18ad4ebf2d335e47dac8bd8
https://doi.org/10.1016/s0300-483x(98)00048-1
https://doi.org/10.1016/s0300-483x(98)00048-1
Publikováno v:
Toxicology. 123:197-206
Livers of male rats were perfused for 120 min in a recirculating hemoglobin-free system with different concentrations of cyclosporine (CS 2, 10, 50, 150 and 200 mg/l). CS produced damage to the livers in a dose dependent manner. The first sign of hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2812977b85dd3b82c1bece04e8a424e
https://doi.org/10.1016/s0300-483x(97)00123-6
https://doi.org/10.1016/s0300-483x(97)00123-6
Publikováno v:
Pharmacology & Toxicology. 75:280-284
In previous studies using isolated perfused rat livers, we have shown that reactive oxygen species are involved in hypoxic and ischaemic liver damage. Since albumin was shown to possess strong antioxidant properties we now investigated the capacity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada275f174fc2d8c1c0f4fcba241df74
https://doi.org/10.1111/j.1600-0773.1994.tb00361.x
https://doi.org/10.1111/j.1600-0773.1994.tb00361.x
Publikováno v:
Journal of toxicology. Clinical toxicology. 37(1)
The intravenous infusion of caffeine-sodium salicylate (15 mg/kg/min) into artificially ventilated and anesthetized rats caused a progressive fall in arterial blood pressure which was mainly due to a decrease in peripheral resistance. Cardiac output
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcfb026e99a742bb75b3d786aa41e85
https://pubmed.ncbi.nlm.nih.gov/10078157
https://pubmed.ncbi.nlm.nih.gov/10078157
Publikováno v:
Pharmacology & Toxicology. 71:278-283
Isolated perfused livers from rats fasted overnight were subjected to 30 min. of hypoxia followed by reoxygenation for 60 min., resulting in marked cytotoxicity as evidenced by an enhanced release of cytosolic enzymes (lactate dehydrogen-ase: 14-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd02466f4bfacddbff15d48c1144282
https://doi.org/10.1111/j.1600-0773.1992.tb00983.x
https://doi.org/10.1111/j.1600-0773.1992.tb00983.x
Autor:
Maged Younes, Otfried Strubelt
Publikováno v:
Toxicology. 66:63-74
The toxic potential of sodium ortho vanadate towards isolated perfused rat livers was investigated at a dose of 2 mmol/l. In livers from fasted rats, vanadate led to a release of cytosolic (glutamate-pyruvate-transaminase (GPT) and lactate dehydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad289d49d79cdd0df8e64e36149c0edd
https://doi.org/10.1016/0300-483x(91)90178-4
https://doi.org/10.1016/0300-483x(91)90178-4
Autor:
Otfried Strubelt, Maged Younes
Publikováno v:
Pharmacologytoxicology. 84(3)
The mutual potentiation of the hepatotoxic effects of ethanol and hypoxia raised the question of whether such an interaction also occurs in the cardiovascular system. Therefore, anaesthetized rats were infused intravenously with ethanol (25 mg/kg×mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59815381919565a3e234050256b5456
https://pubmed.ncbi.nlm.nih.gov/10193668
https://pubmed.ncbi.nlm.nih.gov/10193668
Autor:
Otfried Strubelt, Uwe Peters
Publikováno v:
Pharmacology & Toxicology. 67:188-190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a1823a90872d004a3771f92707b6f8
https://doi.org/10.1111/j.1600-0773.1990.tb00810.x
https://doi.org/10.1111/j.1600-0773.1990.tb00810.x