Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Otacilio C, Moreira"'
Autor:
Juliana Magalhães Chaves Barbosa, Yasmin Pedra-Rezende, Hílton Antônio Mata-Santos, Glaucia Vilar-Pereira, Tatiana Galvão de Melo, Isalira Peroba Ramos, Daniel Gibaldi, Otacilio C. Moreira, Daniela Ferreira Nunes, Marcos Meuser Batista, Joseli Lannes-Vieira, Anissa Daliry, Kelly Salomão
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116742- (2024)
Chagasic chronic cardiomyopathy (CCC) is the primary clinical manifestation of Chagas disease (CD), caused by Trypanosoma cruzi. Current therapeutic options for CD are limited to benznidazole (Bz) and nifurtimox. Amiodarone (AMD) has emerged as most
Externí odkaz:
https://doaj.org/article/74fee9ebb1cf46189e361f19dbc83ea9
Autor:
Amanda Faier-Pereira, Paula Finamore-Araujo, Carlos Ramon do Nascimento Brito, Eldrinei Gomes Peres, Klenicy Kazumy de Lima Yamaguchi, Daniele Pereira de Castro, Otacilio C. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5531 (2024)
Currently, approximately 70% of new cases of Chagas disease (CD) in Brazil are attributed to oral transmission, particularly through foods such as açaí, bacaba, and sugarcane juice, primarily in the northern and northeastern regions of the country.
Externí odkaz:
https://doaj.org/article/8b27358d1ac6426d8a0e7bb1bba211d8
Autor:
Mariana M. Paz, Giulia D. S. Ferretti, Mafalda M. C. Martins-Dinis, Beatriz I. S. Ferreira, Amanda Faier-Pereira, Thibaut Barnoud, Otacilio C. Moreira, Jerson L. Silva, Yraima Cordeiro, Luciana P. Rangel
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Although many therapeutic options are available, several factors, including the presence of p53 mutations, impact tumor development and therapeutic resistan
Externí odkaz:
https://doaj.org/article/a63a21b730f141c89ca914e08c92a1d4
Autor:
Camila Patricio Braga Filgueira, Daniela Pitta-Pereira, Lilian Motta Cantanhêde, Gabriel Eduardo Melim Ferreira, Sayonara Dos Reis, Elisa Cupolillo, Otacilio C. Moreira, Constança Britto, Mariana Côrtes Boité
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14784 (2023)
High Resolution Melting Analysis (HRM) has been pointed out as a suitable alternative method to detect and identify Leishmania species. Herein, we aimed to evaluate the sensitivity, specificity, accuracy, and limitations of a HSP70-HRM protocol both
Externí odkaz:
https://doaj.org/article/9c2eb290d0124d5d9017cbddf0d72ab3
Autor:
Jéssica S. Souza, Priscila S. G. Farani, Beatriz I. S. Ferreira, Helene S. Barbosa, Rubem F. S. Menna-Barreto, Otacilio C. Moreira, Rafael M. Mariante
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Toxoplasma gondii is the causative agent of toxoplasmosis, a disease that affects warm-blooded animals and one third of the human population worldwide. Pregnant women who have never been exposed to the parasite constitute an important risk group, as
Externí odkaz:
https://doaj.org/article/1bf5aaef5249441a8a5b78bff0c33fd0
Autor:
Otacilio C. Moreira, Alice Gomes Fernandes, Natalia Lins da Silva Gomes, Carolina Messias dos Santos, Thiago Jacomasso, Alexandre Dias Tavares Costa, Lucas de O. Rossetti Nascimento, Alejandro Marcel Hasslocher-Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Luis Gustavo Morello, Fabricio Klerynton Marchini, Marco Aurelio Krieger, Constança Britto
Publikováno v:
Life, Vol 13, Iss 6, p 1236 (2023)
In the absence of validated biomarkers to control the cure of Chagas disease, PCR-based diagnosis is being used as the main tool for an early indication of therapeutic failure. However, since it is considered a technique of complex reproducibility, m
Externí odkaz:
https://doaj.org/article/7ecc1aca7ffa4dc7a750874ad043947f
Autor:
Ingeborg Becker, Haydee Miranda-Ortiz, Edith A. Fernández-Figueroa, Sokani Sánchez-Montes, Pablo Colunga-Salas, Estefanía Grostieta, Javier Juárez-Gabriel, Yokomi N. Lozano-Sardaneta, Minerva Arce-Fonseca, Olivia Rodríguez-Morales, Gabriela Meneses-Ruíz, Sergio Pastén-Sánchez, Irma López Martínez, Saúl González-Guzmán, Vladimir Paredes-Cervantes, Otacilio C. Moreira, Paula Finamore-Araujo, Julio C. Canseco-Méndez, Uriel Coquis-Navarrete, Laura Rengifo-Correa, Constantino González-Salazar, Myrna M. Alfaro-Cortés, Jorge A. Falcón-Lezama, Roberto Tapia-Conyer, Christopher R. Stephens
Publikováno v:
Pathogens, Vol 12, Iss 3, p 368 (2023)
(1) Background: Chagas disease is the main neglected tropical disease in America. It is estimated that around 6 million people are currently infected with the parasite in Latin America, and 25 million live in endemic areas with active transmission. T
Externí odkaz:
https://doaj.org/article/f940f9e29a234e70a5275840d7dc166a
Autor:
Yasmin Pedra-Rezende, Juliana M. C. Barbosa, Ana Cristina S. Bombaça, Luiza Dantas-Pereira, Daniel Gibaldi, Glaucia Vilar-Pereira, Hílton Antônio Mata dos Santos, Isalira Peroba Ramos, Natália Lins Silva-Gomes, Otacilio C. Moreira, Joseli Lannes-Vieira, Rubem F. S. Menna-Barreto
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease and a health problem in Latin America. Etiological treatment has limited effectiveness in chronic CD; thus, new therapeutic strategies are required. The p
Externí odkaz:
https://doaj.org/article/64463a27e7704e30b822434f346db02a
Autor:
Marcelo T. Holanda, Mauro F.F. Mediano, Alejandro M. Hasslocher-Moreno, Beatriz M.S. Gonzaga, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Fernanda S. Pereira-Silva, Luis O. Pimentel, Marcelo O. Mendes, Marcos J. Azevedo, Constança Britto, Otacilio C. Moreira, Alice G. Fernandes, Carolina M. Santos, Jéssica Constermani, Vitor B. Paravidino, Erica R. Maciel, Fernanda M. Carneiro, Sérgio S. Xavier, Gilberto M. Sperandio da Silva, Priscila F. Santos, Henrique H. Veloso, Pedro E.A.A. Brasil, Andrea S. de Sousa, Maria G. Bonecini-de-Almeida, Paula S. da Silva, Luiz Henrique C. Sangenis, Roberto M. Saraiva, Tania C. Araujo-Jorge
Publikováno v:
EClinicalMedicine, Vol 40, Iss , Pp 101105- (2021)
Background: Chagas disease (caused by Trypanosoma cruzi infection) evolves to chronic chagasic cardiomyopathy (CCC) affecting 1.8 million people worldwide. This is the first randomized, placebo-controlled, double-blinded, clinical trial designed to e
Externí odkaz:
https://doaj.org/article/813190663da340899121d57aac7d3a17
Autor:
Natália Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane França da Silva, Denise da Gama Jaen Batista, Stênio Fragoso, Gabriel Melo de Oliveira, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14661 (2022)
Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T. cruzi plasma membrane, which hydrolyze a wide range of tri-/-diphosphate nucleosides. In this work, we used previously developed genetically modi
Externí odkaz:
https://doaj.org/article/ee0c666e8d554b9b80e43f753e64ee29