Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Otávio A, Chaves"'
Publikováno v:
Acta Scientiarum: Education, Vol 46, Iss 1 (2024)
Neste artigo refletimos sobre a análise arqueológica do discurso (AAD) enquanto possibilidade de formação humana e educativa. Nossa problemática: quais as possibilidades da AAD instaurar práticas e processos educativos assentados na alteridade?
Externí odkaz:
https://doaj.org/article/d880214f117a497a9c117737d17a178c
Autor:
Otávio Augusto Chaves, Cosme H.C. dos Santos Oliveira, Romulo Correia Ferreira, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Carlos Serpa, Dari Cesarin-Sobrinho, Francisco de Assis da Silva, José Carlos Netto-Ferreira
Publikováno v:
Chemical Physics Impact, Vol 8, Iss , Pp 100465- (2024)
The interactive profile between human serum albumin (HSA, the main carrier of endogenous and exogenous compounds in the human bloodstream) and five potential anticandidal agents, namely 2,3-dihydro-2-phenyl-naphtho[1,2-b]furan-4,5‑dione (1) and its
Externí odkaz:
https://doaj.org/article/9f4f0cd6a3434eb18d0c42c5dd4ed7bb
Autor:
Otávio Augusto Chaves, Cosme H.C. dos Santos Oliveira, Romulo Correia Ferreira, Dari Cesarin-Sobrinho, Antonio Eduardo da Hora Machado, José Carlos Netto-Ferreira
Publikováno v:
Chemical Physics Impact, Vol 8, Iss , Pp 100411- (2024)
Spectroscopic studies were carried out for the interaction of the bioactive compounds 2,3-dimethoxyxanthone (1) and 3,4-dimethoxyxanthone (2) with human serum albumin (HSA). The UV absorption, steady-state, and time-resolved fluorescence spectroscopy
Externí odkaz:
https://doaj.org/article/4f681a31e35e4a3db97a6fea09850d32
Autor:
Rita S. Cunha, Pedro F. Cruz, Telma Costa, Zaida L. Almeida, Marco Edilson Freire de Lima, Carlos Serpa, Otávio A. Chaves
Publikováno v:
Molecules, Vol 29, Iss 13, p 3001 (2024)
Ketoprofen (KTF) and ketorolac (KTL) are among the most primarily used non-steroidal anti-inflammatory drugs (NSAIDs) in humans to alleviate moderate pain and to treat inflammation. Their binding affinity with albumin (the main globular protein respo
Externí odkaz:
https://doaj.org/article/99640d5b9b9e40b79b5ef60de7a98d15
Autor:
Liniquer André Fontana, Francisco Mainardi Martins, Josiéli Demetrio Siqueira, Carlos Serpa, Otávio Augusto Chaves, Davi Fernando Back
Publikováno v:
Inorganics, Vol 12, Iss 6, p 171 (2024)
This study sought to investigate the synthesis of eight complexes constituted by a cobalt(III) (CoIII) metallic center coordinated to two units of iminic ligands LnC (n = 1–4, L1C–L4C), which are derivatives of pyridoxal hydrochloride and aniline
Externí odkaz:
https://doaj.org/article/c5e7fba05a8547a7820947ee21a3a6d7
Autor:
Marilia Amável Gomes Soares, Franklin Souza-Silva, Carlos Roberto Alves, Leonardo Vazquez, Talita Stelling de Araujo, Carlos Serpa, Otávio Augusto Chaves
Publikováno v:
Scientia Pharmaceutica, Vol 92, Iss 2, p 32 (2024)
Cardiovascular diseases (CVDs), especially arterial hypertension, stand as prominent contributors to global mortality. Regrettably, individuals with diabetes encounter a two-fold increase in the risk of mortality associated with CVDs. Hydrochlorothia
Externí odkaz:
https://doaj.org/article/133632add5734314b0621b7638c1d65b
Autor:
Andreia Costa-Tuna, Otávio A. Chaves, Zaida L. Almeida, Rita S. Cunha, João Pina, Carlos Serpa
Publikováno v:
Viruses, Vol 16, Iss 4, p 491 (2024)
Tenofovir (TFV) is the active form of the prodrugs tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF), both clinically prescribed as HIV reverse transcriptase inhibitors. The biophysical interactions between these compounds and human
Externí odkaz:
https://doaj.org/article/343f2ffd7f0a477a83f598896775a16a
Autor:
Amanda Resende Tucci, Raquel Mello da Rosa, Alice Santos Rosa, Otávio Augusto Chaves, Vivian Neuza Santos Ferreira, Thamara Kelcya Fonseca Oliveira, Daniel Dias Coutinho Souza, Nathalia Roberto Resende Borba, Luciano Dornelles, Nayra Salazar Rocha, João Candido Pilar Mayer, João B. Teixeira da Rocha, Oscar Endrigo D. Rodrigues, Milene Dias Miranda
Publikováno v:
Molecules, Vol 28, Iss 18, p 6696 (2023)
The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can increase the bioactivity and reduce the toxicity of AZT has directed our search for the discove
Externí odkaz:
https://doaj.org/article/8107e95898674965bfca4918fd845c8f
Autor:
Xuanting Wang, Carolina Q. Sacramento, Steffen Jockusch, Otávio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R. Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, Patrícia T. Bozza, James J. Russo, Thiago Moreno L. Souza, Jingyue Ju
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
In this paper, the hepatitis C virus inhibitors Pibrentasvir and Ombitasvir are found to inhibit the SARS-CoV-2 exonuclease and are shown to have therapeutic potential when combined with SARS-CoV-2 polymerase inhibitors in viral cell cultures.
Externí odkaz:
https://doaj.org/article/421885d8a61b464da42eeec94cc924d8
Autor:
Bernardo Almeida Iglesias, Níckolas Pippi Peranzoni, Sophia Iwersen Faria, Luana Belo Trentin, André Passaglia Schuch, Otávio Augusto Chaves, Renan Ribeiro Bertoloni, Sofia Nikolaou, Kleber Thiago de Oliveira
Publikováno v:
Molecules, Vol 28, Iss 13, p 5217 (2023)
We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscop
Externí odkaz:
https://doaj.org/article/1dd1717e50c24562aa7e102624db1fe3