Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Osvaldo Cox"'
Publikováno v:
Journal of cancer prevention & current research
This study presents the applicability of a novel nitro-substituted heterocyclic compound NBQ48, member of the family of compounds identified as 3 nitrobenzazolo[3, 2-a] quinolinium chloride salts (NBQS) as a screening tool to identify hypoxic tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257c4e2badff03a1b9fe2d708448dd5c
https://doi.org/10.15406/jcpcr.2020.11.00417
https://doi.org/10.15406/jcpcr.2020.11.00417
Autor:
Christian Velez, Ana I. Ortiz-Colón, Karoline Rios, Luz Silva, Beatriz Zayas, Luis A. Rivera, Osvaldo Cox, Jessica Soto, Wigberto J. Hernandez
Publikováno v:
The Open Medicinal Chemistry Journal
Objectives: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2-a]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to known anti-cancer substances such as ellipticine and berberin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f72f5ab19803cd9f330d410e3a99447
https://doi.org/10.2174/1874104501711010054
https://doi.org/10.2174/1874104501711010054
Autor:
Vineet Kumar, Luis A. Rivera, Sanjay V. Malhotra, Osvaldo Cox, Christian Velez, Wigberto J. Hernandez, José R. Martínez, Marisol Cordero, Beatriz Zayas
Publikováno v:
Current Bioactive Compounds. 10:286-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5e503ea9bba18939dc5c30c6079d771
https://doi.org/10.2174/1573407210666141126204355
https://doi.org/10.2174/1573407210666141126204355
Autor:
Vineet Kumar, Sujey Carro, Sanjay V. Malhotra, Luz Arroyo, Osvaldo Cox, Christian Velez, Dennise Molina, Anton Filikov, Beatriz Zayas, Carlos A. Rosado-Berrios, Marisol Cordero
Publikováno v:
Open journal of apoptosis
This study reports the capacity of three nitro substituted benzazolo[3,2-a]quinolinium salts NBQs: NBQ 95 (NSC-763304), NBQ 38 (NSC 763305), and NBQ 97 (NSC-763306) as potential antitumor agents. NBQ’s are unnatural alkaloids possessing a positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc41b4be1442aab6d137b1b991fc2958
http://europepmc.org/articles/PMC4169051
http://europepmc.org/articles/PMC4169051
Publikováno v:
Journal of Heterocyclic Chemistry. 45:1255-1264
A high degree of regioselectivity is observed in the photochemically induced cyclization of (E)-2-(2,3,6-trichlorostyryl)benzothiazole (1a). According to the proposed mechanism, this compound was expected to afford two products, 3,4-dichloro- and 1,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f2e467c704c03bc16bfe9395823b6b
https://doi.org/10.1002/jhet.5570450501
https://doi.org/10.1002/jhet.5570450501
Autor:
Beatriz Zayas, Antonio E. Alegria, Fernando A. González, Ajay Kumar, Christian Velez, Iris Gisela Colón, Osvaldo Cox, Marisol Cordero
Publikováno v:
Chemical Research in Toxicology. 21:1706-1715
Interest in DNA binding drugs has increased in recent years due to their importance in the treatment of genome-related diseases, like cancer. A new family of water-soluble DNA binding compounds, the benzothiazolo[3,2- a]quinolinium chlorides (BQCls),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a726f192afed55ede770513fc004dd
https://doi.org/10.1021/tx800076c
https://doi.org/10.1021/tx800076c
Autor:
Osvaldo Cox, Beatriz Zayas, Wigberto J. Hernandez, Marisol Cordero, Maria Terron, Antonio E. Alegria, Juan Beyley
Publikováno v:
Toxicology in Vitro. 21:1155-1164
The DNA binding capacity of two nitro-substituted benzazolo[3,2-a]quinolinium chlorides (NBQs), NBQ-38 and NBQ-95, was evaluated upon their enzymatic reduction with hypoxanthine (HX)/xanthine oxidase (XO) under anaerobic conditions. In the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ef62d7be508becf066e2a75fb4cb59
https://doi.org/10.1016/j.tiv.2007.03.004
https://doi.org/10.1016/j.tiv.2007.03.004
Autor:
Pedro Sanchez-Cruz, L. A. Rivera, Antonio E. Alegria, Wilmarie Flores, Osvaldo Cox, Marisol Cordero, Emelyn Cordones
Publikováno v:
Toxicology. 199:87-96
Derivatives of benzazolo[3,2-a]quinolium salts (QSDs) are reductively activated by the enzymatic reducing agents hypoxanthine (or xanthine)/xanthine oxidase and NADH dehydrogenase as evidenced by the increase in rates of ferricytochrome c (Cyt(III)c)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a204e13d45d952b2bedf3f19bf976dc
https://doi.org/10.1016/j.tox.2003.11.017
https://doi.org/10.1016/j.tox.2003.11.017
Publikováno v:
Journal of Heterocyclic Chemistry. 36:943-947
The electrochemical reduction of the chloride or perchlorate salts of benzazolo[3,2-a]quinolinium ion and several of its analogues is reported. The compounds studied are the perchlorate salt of 3-nitrobenzothiazolo-and 3-nitro-9-methoxybenzothiazolo[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8b8dcdc0b86c7914d94fda9c70509bf
https://doi.org/10.1002/jhet.5570360420
https://doi.org/10.1002/jhet.5570360420
Publikováno v:
Journal of Heterocyclic Chemistry. 36:937-942
Several hitherto unknown thiazolo[3,2-a]quinolinium salts derivatives were prepared and characterized. Two-dimensional high field nmr methods were employed to make complete assignments of the proton and carbon nmr spectra for these compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2751a321b22106cefdc154b67e38d066
https://doi.org/10.1002/jhet.5570360419
https://doi.org/10.1002/jhet.5570360419