Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines.

Autor: Ostrovskii, Vladimir А.¹ (AUTHOR) va_ostrovskii@mail.ru, Danagulyan, Gevorg G.^2,3 (AUTHOR), Nesterova, Olga M.¹ (AUTHOR), Pavlyukova, Yulia N.¹ (AUTHOR), Tolstyakov, Vladimir V.¹ (AUTHOR), Zarubina, Olga S.¹ (AUTHOR), Slepukhin, Pavel А.⁴ (AUTHOR), Esaulkova, Yana L.⁵ (AUTHOR), Muryleva, Anna А.⁵ (AUTHOR), Zarubaev, Vladimir V.⁵ (AUTHOR), Trifonov, Rostislav E.¹ (AUTHOR)

Publikováno v: Chemistry of Heterocyclic Compounds. Apr2021, Vol. 57 Issue 4, p448-454. 7p.

Synthesis of isomeric 4-( N -methyltetrazolylamino)-2-phenyl-4 H -thiopyrano[2,3- b ]quinoline-3-carbaldehydes and 4-hydroxy-2-phenyl-4 H -thiopyrano[2,3- b ]quinoline-3-carbaldehyde based on tandem thiol-Michael and (aza)-Morita-Baylis-Hillman reactions and an in vitro study of the activity of the obtained compounds against influenza virus.

Autor: Khramchikhin AV; Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia., Skryl'nikova MА; Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia., Pavlyukova YN; Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia., Zarubaev VV; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St, Saint Petersburg, 197101 Russia., Esaulkova YL; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St, Saint Petersburg, 197101 Russia., Muryleva AА; Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St, Saint Petersburg, 197101 Russia., Shmanyova NT; Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia., Danagulyan GG; Russian-Armenian University, 123 Hovsep Emin St, 0051 Yerevan, Armenia.; Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, 26a Azatutyan Ave, 0014 Yerevan, Armenia., Ostrovskii VА; Saint Petersburg State Institute of Technology (Technical University), 26 Moskovsky Ave, Saint Petersburg, 190013 Russia.

Publikováno v: Chemistry of heterocyclic compounds [Chem Heterocycl Compd (N Y)] 2022; Vol. 58 (4-5), pp. 267-270. Date of Electronic Publication: 2022 May 25.