Výsledky vyhledávání - "Osteoprogenitor"

Akademický článek

Transcriptomic Signature and Pro-Osteoclastic Secreted Factors of Abnormal Bone-Marrow Stromal Cells in Fibrous Dysplasia

Autor: Zachary Michel, Layne N. Raborn, Tiahna Spencer, Kristen S. Pan, Daniel Martin, Kelly L. Roszko, Yan Wang, Pamela G. Robey, Michael T. Collins, Alison M. Boyce, Luis Fernandez de Castro

Publikováno v: Cells, Vol 13, Iss 9, p 774 (2024)

Fibrous dysplasia (FD) is a mosaic skeletal disorder caused by somatic activating variants of GNAS encoding for Gαs and leading to excessive cyclic adenosine monophosphate signaling in bone-marrow stromal cells (BMSCs). The effect of Gαs activation

Externí odkaz: https://doaj.org/article/d85b2c1f4ad94017b9c18b33b85b0365

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Akademický článek

Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice

Autor: Xiaohao Wu, Minghao Qu, Weiyuan Gong, Chunlei Zhou, Yumei Lai, Guozhi Xiao

Publikováno v: Journal of Orthopaedic Translation, Vol 32, Iss , Pp 41-48 (2022)

Background: Our recent studies demonstrate that the focal adhesion protein Kindlin-2 exerts crucial functions in the mesenchymal stem cells, mature osteoblasts and osteocytes in control of early skeletal development and bone homeostasis in mice. Howe

Externí odkaz: https://doaj.org/article/fbc0cfc1cd364b4abc6632951716dc92

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Akademický článek

Postnatal Osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury

Autor: Evan G. Buettmann, Susumu Yoneda, Pei Hu, Jennifer A. McKenzie, Matthew J. Silva

Publikováno v: Frontiers in Physiology, Vol 13 (2023)

Murine models of long-bone fracture, stress fracture, and cortical defect are used to discern the cellular and molecular mediators of intramembranous and endochondral bone healing. Previous work has shown that Osterix (Osx+) and Dentin Matrix Protein

Externí odkaz: https://doaj.org/article/6e4b7e79b41e41079e73041107f7727b

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Akademický článek

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Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation

Autor: Rubens Sautchuk, Brianna H Kalicharan, Katherine Escalera-Rivera, Jennifer H Jonason, George A Porter, Hani A Awad, Roman A Eliseev

Publikováno v: eLife, Vol 11 (2022)

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore (MPTP) which plays a key role in both cell physiology and pathology. It is, therefore, beneficial for cells to tightly regulate CypD and MPTP but little is known

Externí odkaz: https://doaj.org/article/31fd707cae064039a605cbafca3401bd

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Akademický článek

High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells

Autor: Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane, Wei Yao

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-12 (2020)

Abstract Background Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively deleted PR from osteoprog

Externí odkaz: https://doaj.org/article/23f1a557b22e4e4789a2f7c69a8588bc

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Akademický článek

Intermittent Exposure to a 16 Hz Extremely Low Frequency Pulsed Electromagnetic Field Promotes Osteogenesis In Vitro through Activating Piezo 1-Induced Ca2+ Influx in Osteoprogenitor Cells

Autor: Yangmengfan Chen, Benedikt J. Braun, Maximilian M. Menger, Michael Ronniger, Karsten Falldorf, Tina Histing, Andreas K. Nussler, Sabrina Ehnert

Publikováno v: Journal of Functional Biomaterials, Vol 14, Iss 3, p 165 (2023)

Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is supposed to simulate local EMF generated during mechanical stimulation of bone and may therefore be used to improve bone regeneration. This study aimed at optimizing the

Externí odkaz: https://doaj.org/article/aa587e96a0844d6ab9b32151e8ff5057

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Akademický článek

Synthesis of scaffold-free, three dimensional, osteogenic constructs following culture of skeletal osteoprogenitor cells on glass surfaces

Autor: Latifa Alghfeli, Divyasree Parambath, Shaista Manzoor, Helmtrud I. Roach, Richard O.C. Oreffo, Ahmed T. El-Serafi

Publikováno v: Bone Reports, Vol 15, Iss , Pp 101143- (2021)

Background: Efficient differentiation of stem cells into three-dimensional (3D) osteogenic construct is still an unmet challenge. These constructs can be crucial for patients with bone defects due to congenital or traumatic reasons. The modulation of

Externí odkaz: https://doaj.org/article/dd329a1753794badbf3377318595f849

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Akademický článek

TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation

Autor: Chunmei Xu, Xudong Xie, Hu Zhao, Yafei Wu, Jun Wang, Jian Q. Feng

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Transforming growth factor beta (TGFβ) signaling plays an important role during osteogenesis. However, most research in this area focuses on cortical and trabecular bone, whereas alveolar bone is largely overlooked. To address the role of TGFβR2 (t

Externí odkaz: https://doaj.org/article/785481fae129472682a4bdc483905fa6

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