Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Osteoclast maturation"'
Autor:
Yuhan Deng, Fangli Peng, Peiyuan Zhang, Xiangyin Kong, Guohong Hu, Chengxin Ma, Yuan Wang, Xiaoxun Li, Tong Liu, Yunfei He, Yansen Xiao, Yajun Liang, Yunpeng Su, Qingcheng Yang, Cheng Lian, Cheng Luo
Publikováno v:
Theranostics
Background: Bone metastasis is a frequent symptom of breast cancer and current targeted therapy has limited efficacy. Osteoclasts play critical roles to drive osteolysis and metastatic outgrowth of tumor cells in bone. Previously we identified CST6 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b3eb0af4f3e6b68535b6680f2d938
http://europepmc.org/articles/PMC8581426
http://europepmc.org/articles/PMC8581426
Autor:
Nam Young Kim, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Narae Kim, Woojin Jeong, Hyun Jin Kim, Dong Min Shin, Hye In Lee, Jin Ha Park, Gong Rak Lee, Jiae Lee, TaeSoo Kim
Publikováno v:
Journal of Cellular Physiology. 236:8239-8252
Many bone diseases such as osteoporosis and periodontitis are caused by hyperactivation of osteoclasts. Calcium (Ca2+ ) signals are crucial for osteoclast differentiation and function. Thus, the blockade of Ca2+ signaling may be a strategy for regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c880d494e5e0ae3ffc742a63390566
https://doi.org/10.1002/jcp.30496
https://doi.org/10.1002/jcp.30496
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-24 (2021)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting. Its controversial pharmacology and often species-dependent regulation have impacted upon th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d72940f5919722e471f696963bcaf2
https://doaj.org/article/896c276128f34a83ba13779a313a214f
https://doaj.org/article/896c276128f34a83ba13779a313a214f
Autor:
Kazutoshi Sayama, Akira Yukita, Takumi Takahashi, Tadashi Ninomiya, Hiroaki Nakamura, Tsuyoshi Koide, Yuji Imai, Rina Iwamoto, Kazuto Yoshimi, Miroku Hara
Publikováno v:
Journal of Bone and Mineral Metabolism. 39:558-571
Bone metabolism imbalances cause bone metabolism diseases, like osteoporosis, through aging. Although some chemokines are known to be involved in bone mass regulation, many have not been investigated. Thus, the present study aimed to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a441f852e0ba3496adb5aceaee5ea63
https://doi.org/10.1007/s00774-021-01210-9
https://doi.org/10.1007/s00774-021-01210-9
Autor:
Moran Shalev, Sergey Kapishnikov, Esther Arman, Merle Stein, Isabelle Royal, Vlad Brumfeld, Ari Elson, Jan Tuckermann, Yael Cohen-Sharir
Publikováno v:
The FEBS Journal. 288:4702-4723
Bone-resorbing osteoclasts (OCLs) are multinucleated phagocytes, whose central roles in regulating bone formation and homeostasis are critical for normal health and development. OCLs are produced from precursor monocytes in a multistage process that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27be8d3508c10d7c35e4fed2edb35696
https://doi.org/10.1111/febs.15778
https://doi.org/10.1111/febs.15778
Autor:
Li Yuwei, Xiaofeng Shen, Pengfei Yu, Li Su, Hua Chen, Guoqiang Liang, Jiangping Wang, Qihan Ma, Chenxi Zhang, Xiaochen Sun, Lu Binjie, Yuanyuan Qin
Publikováno v:
Cancer Chemotherapy and Pharmacology. 87:487-499
Bone is the most common late metastasis of breast cancer. Bone metastasis causes not only severe bone pain, but also bone-related diseases such as pathological fractures, which are closely related to osteoclasts. The effects of demethoxycurcumin (DMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8d010fa4da3bda0852c96b30959a74
https://doi.org/10.1007/s00280-020-04198-7
https://doi.org/10.1007/s00280-020-04198-7
Autor:
Danarto Hari Adhimukti, Ihsan Oesman
Publikováno v:
International Journal of Surgery Case Reports
Highlights • Despite advances in the diagnosis and treatment of systemic lupus erythematosus (SLE), symptomatic osteonecrosis continues to be a significant comorbidity. • Strategies to detect and manage early stages of osteonecrosis is necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30b63c00efcf16a94b1436373aa3d2b
https://doi.org/10.1016/j.ijscr.2020.10.069
https://doi.org/10.1016/j.ijscr.2020.10.069
Publikováno v:
Journal of Cellular and Molecular Medicine
Wear particle‐stimulated inflammatory bone destruction and the consequent aseptic loosening remain the primary causes of artificial prosthesis failure and revision. Previous studies have demonstrated that curcumin has a protective effect on bone di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ce4b2913fc015f36c0d480205708c0
https://doi.org/10.1111/jcmm.14842
https://doi.org/10.1111/jcmm.14842
Autor:
Peter A. Nigrovic, Matthew P. Harris, M. Sury, Katia Urso, Joana Caetano-Lopes, Katrin Henke, Jing Yan, M. Zgoda, Pui Y. Lee, Christian E. Jacome-Galarza, H. Liu, Julia F. Charles, Jeffrey Duryea
Publikováno v:
Bone
G protein-coupled receptor 137b (GPR137b) is an orphan seven-pass transmembrane receptor of unknown function. In mouse, Gpr137b is highly expressed in osteoclasts in vivo and is upregulated during in vitro differentiation. To elucidate the role that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0908f6ed5974234a967b9fb14471b3dc
https://doi.org/10.1016/j.bone.2019.06.002
https://doi.org/10.1016/j.bone.2019.06.002
Autor:
Jaimo Ahn, Peeyush N. Goel, Yasaman Moharrer, Alexander J. Egol, Jason W. Ashley, Beatrix Brandfield-Harvey
Publikováno v:
Biochem Biophys Res Commun
Chronic inflammatory responses have profound effects on the differentiation and activity of both the bone-forming osteoblasts and bone-resorbing osteoclasts. Importantly, inflammatory bone diseases characterized by clinical osteolysis promote bone re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2e4a534cc3befa1a8dc2e7458a3541
https://doi.org/10.1016/j.bbrc.2019.05.166
https://doi.org/10.1016/j.bbrc.2019.05.166